Results 261 to 270 of about 349,615 (316)

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source

Glycogen supports glycolytic plasticity in neurons. [PDF]

Proc Natl Acad Sci U S A
Singh M, Wolfe AD, Vishwanath AA, Tsives A, Gonzalez IJ, Emerson SE, Goodman R, Colón-Ramos D.   +7 more
europepmc   +1 more source

Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

Advanced Science, EarlyView.
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang, Shuaiyang Jing, Haojun Li, Bao Xiao, Jiahui Jin, Xiu Sun, Juan Wang, Jing Liang, Tongze Cai, Huili Hu, Meilan Wei, Xuanrui Zhong, Yang Ji, Peng George Wang, Jianlong Zhou   +14 more
wiley   +1 more source

RNA-seq analysis of blood from cave- and surface-dwelling <i>Astyanax</i> morphs reveal diverse transcriptomic responses to normoxic rearing. [PDF]

Front Physiol
Boggs TE, Bucher LR, Gross JB.
europepmc   +1 more source

NIR Driven Pd/Cerium Oxide Nano‐Heterojunction for Enhanced Salvaging Sepsis Induced Acute Liver Injury via Reprogramming Redox Homeostasis in Synergy with Inducing Autophagy

Advanced Science, EarlyView.
In vivo SALI therapy is achieved by scavenging intracellular ROS levels, downregulating inflammatory factors expression levels, inducing macrophage M2 directional polarization, and activating Keap1/Nrf‐2/HO‐1 pathway to reprogram redox homeostasis, induce cellular autophagy, reduce systemic inflammation, and promote liver tissue repair. Abstract Sepsis
Tao Qin, Lian Qin, Yang Zhao, Yin Chen, Qianyue Liu, Xiaoguang Lin, Yongfeng Lan, Yaohui Huang, Yan Liu, Ke Zhang, Lifan Pan, Jiaxiao Li, Kunpeng Duan, Hao Liang, Mingjing Yin, Guiyang Fan, Lian Liu, Yu Deng, Lin Liao, Danke Su, Ming Gao, Junyu Lu   +21 more
wiley   +1 more source

Correction: Intermittent hypoxia regulates stem-like characteristics and differentiation of neuroblastoma cells. [PDF]

PLoS One
Bhaskara VK, Mohanam I, Rao JS, Mohanam S.   +3 more
europepmc   +1 more source

Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility

Advanced Science, EarlyView.
Iron overload in ovarian endometriosis (OE) disrupts follicular function and contributes to infertility. This study maps iron‐induced cellular changes using single‐cell and spatial transcriptomics, revealing senescence phenotypes in OE patients and mouse models. Similar patterns are observed in aging ovaries, highlighting iron metabolism as a potential
Yangshuo Li, Wei Zhou, Jie Ding, Di Song, Wen Cheng, Jin Yu, Shuai Sun, Shanshan Mei, Xiaolan Liang, Qianqian Zhao, Yanping Kuang, Mingqing Li, Zhexin Ni, Chaoqin Yu, Yue Gao   +14 more
wiley   +1 more source

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia. [PDF]

Elife
Tian Z, Li Y, Jin F, Xu Z, Gu Y, Guo M, Shao Q, Liu Y, Luo H, Wang Y, Zhang S, Yang C, Liu X, Ji X, Liu J.   +14 more
europepmc   +1 more source

Acidosis attenuates the hypoxic stabilization of HIF-1α by activating lysosomal degradation. [PDF]

J Cell Biol
White B, Wang Z, Dean M, Michl J, Nieora N, Flannery S, Vendrell I, Fischer R, Hulikova A, Swietach P.   +9 more
europepmc   +1 more source

An engineered hypoxia-response promoter for human umbilical cord-derived mesenchymal stem cell-based therapeutics. [PDF]

BMC Biotechnol
Yang S, Zhuang W, Zhou L, Kong W, Zou W, Zhu Q, Bian E, Lin B, Cen J, Gao Q, Chen J.   +10 more
europepmc   +1 more source