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Hypoxia-induced dedifferentiation in neuroblastoma cells
Cancer Letters, 2003Hypoxia in solid tumors is associated with aggressive behavior and poor outcome. We recently discovered that hypoxia alters the expression of differentiation marker genes in neuroblastoma cells, in that the tumor cells adjust to the hypoxic environment by down-regulating genes associated with a neuronal and upregulating genes associated with a neural ...
Annika, Jögi +5 more
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Sickle cell resistance to in vivo hypoxia
Nature, 1974THE rapid disappearance from circulation of human erythrocytes transfused to rats can be prevented if the animals are pretreated with ethyl palmitate (EP) and a cobra venom factor (CVF)1. The improvement in human erythrocyte survival in these animals is due to EP-induced impairment of reticuloendothelial function2 and to suppression of intravascular ...
O, Castro, S C, Finch, G, Osbaldiston
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Hypoxia in the regulation of neural stem cells
Cellular and Molecular Life Sciences, 2011In aerobic organisms, oxygen is a critical factor in tissue and organ morphogenesis from embryonic development throughout post-natal life, as it regulates various intracellular pathways involved in cellular metabolism, proliferation, survival and fate.
Lidia, De Filippis, Domenico, Delia
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Effect of hypoxia on human seminoma cells
International Journal of Oncology, 2002Since hypoxia has been considered to enhance metastatic potential in solid tumors via a neo-angiogenesis caused by vascular endothelial cell growth factors (VEGFs) induced by hypoxia inducible factor-1alpha (HIF-1alpha), the effects of hypoxia on human seminoma cell lines were examined in terms of growth, morphology, gene expression, protein expression
Tomohiro, Fujii +14 more
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Hypoxia and Visualization of the Stem Cell Niche
2013It is widely accepted that mammalian stem cells reside in a specialized cellular and a cellular microenvironment called the niche. The niche contrary to other tissues is characterized by a low partial Oxygen pressure (ppO2). This microenvironment protects stem cells from deleterious effects of O2 on proteins and DNA, through the production of reactive ...
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Endothelial Cells’ Responses to Hypoxia and Reperfusion
1995Our results suggest that longer periods of hypoxia lead to a deficiency of high energy phosphates. Reoxygenation leads to the formation of ROS, irrespectively of the duration of hypoxia. It might be concluded that a diminished level of intracellular high energy phosphates upon hypoxia followed by oxidative stress plays a key role in the reperfusion ...
A, Griesmacher +2 more
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Mechanisms of cell survival in hypoxia and hypothermia
Journal of Experimental Biology, 2001SUMMARYMost animals experience some degree of hypoxia and hypothermia during the course of their natural life history either as a consequence of ambient ‘exposure’ per se or through metabolic, respiratory and/or circulatory insufficiency. A prevailing experimental approach has been to probe tissues from natural models of hypoxia-tolerant and cold ...
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Regulation of cell proliferation by hypoxia-inducible factors
American Journal of Physiology - Cell Physiology, 2015Gregg Semenza
exaly