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Hypoxia and Lactate Production in Trophoblast Cells
Placenta, 2007The etiology of preeclampsia is unknown but is thought to be related to hypoxia in the placenta. We previously reported that the enzyme lactate dehydrogenase (LDH) has increased activity and gene expression in placentas from preeclamptic pregnancies [Tsoi SCM, Zheng J, Xu F, Kay HH.
H H, Kay, S, Zhu, S, Tsoi
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Hypoxia, reactive oxygen, and cell injury
Free Radical Biology and Medicine, 1989Hypoxia usually decreases the formation of reactive oxygen species by oxidases and by autoxidation of components of cellular electron transfer pathways and of quinoid compounds such as menadione. In the case of menadione reactive oxygen species are liberated to a significant extent only at non-physiologically high oxygen partial pressures (PO2).
H, de Groot, A, Littauer
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Hypoxia and Hypoxia Inducible Factors in Cancer Stem Cell Maintenance
2010Hypoxia promotes tumor progression through multiple mechanisms including modifying angiogenesis, metabolism switch and invasion. Hypoxia inducible factors (HIFs), particularly HIF1α and HIF2α, are key mediators in cancer hypoxia response and high expression levels of HIFs correlate with a poor prognosis in various tumor types. Cancer stem cells (CSCs),
Zhizhong, Li, Jeremy N, Rich
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Highlight: sensing hypoxia in the cell and the organism
bchm, 2013No abstract ...
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Cerebral cell population under hypoxia
The Anatomical Record, 1966AbstractThree pregnant albino Sprague‐Dawley rats were subjected to simulated high altitudes of 18,000 feet (365 mm Hg) in low pressure chambers during their entire pregnancy. The brains of the newborn rats were removed immediately after birth and placed in 10% formalin.
R R, Shivers, P G, Roofe
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Hypoxia Tolerance of Coronary Endothelial Cells
1990The coronary endothelium performs a great number of specific metabolic and physiological functions, e.g. the synthesis of autacoids, and the control of the transport of material into and out of the blood stream. For these performances a sufficient supply of metabolic energy is required. Alterations of the energetic state, e.g. due to an insufficient O2
T, Noll +5 more
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Cell-Autonomous Metabolic Reprogramming in Hypoxia
Trends in Cell Biology, 2018Molecular oxygen (O2) is a universal electron acceptor that enables ATP synthesis through mitochondrial respiration in all metazoans. Consequently, hypoxia (low O2) has arisen as an organizing principle for cellular evolution, metabolism, and (patho)biology, eliciting a remarkable panoply of metabolic adaptations that trigger transcriptional ...
Luana Schito, Sergio Rey
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Transcriptional adaptation of neuroblastoma cells to hypoxia
Biochemical and Biophysical Research Communications, 2008Low oxygen pressure (hypoxia) is a physiological condition that has been linked to tumor progression and increased malignancy in several cancer forms. Cells of the childhood neoplasm neuroblastoma respond to hypoxia by attaining a lower grade of differentiation, which clinically is associated with poor prognosis.
Erik, Fredlund +3 more
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Cancer Stem Cells, Hypoxia and Metastasis
Seminars in Radiation Oncology, 2009The successful growth of a metastasis, by definition, requires the presence of at least 1 cancer stem cell. Metastasis is a complex process, and an important contributor to this process is the influence of the tissue microenvironment, both cell-cell and cell-matrix interactions and the pathophysiologic conditions in tumors, such as hypoxia. A number of
Richard P, Hill +2 more
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The impact of hypoxia on cell death pathways
Biochemical Society Transactions, 2013Hypoxia is a frequently encountered feature of the cellular microenvironment in a number of pathophysiological processes in which programmed cell death (apoptosis) affects disease progression including, but not limited to, cancer, chronic inflammation, myocardial infarction, stroke and ischaemic acute kidney injury.
Colin R, Lenihan, Cormac T, Taylor
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