Plasma from Volunteers Breathing Helium Reduces Hypoxia-Induced Cell Damage in Human Endothelial Cells-Mechanisms of Remote Protection Against Hypoxia by Helium. [PDF]
, 2019 PurposeRemote ischemic preconditioning protects peripheral organs against prolonged ischemia/reperfusion injury via circulating protective factors. Preconditioning with helium protected healthy volunteers against postischemic endothelial dysfunction.
Augustijn, Quinten JJ +7 more
core +1 more source
Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
Journal of Hematology & Oncology, 2022 Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity.
Qinghua Wu +6 more
semanticscholar +1 more source
Reducing the hypoxic fraction of a tumour model by growth in low glucose. [PDF]
, 1989 The question of whether growth under low glucose conditions leads to a reduced amount of cell hypoxia was investigated using an in vitro tumour analogue, the sandwich system.
Hlatky, L, Ring, C, SACHS, Rainer K.
core +3 more sources
Hypoxia signaling in human health and diseases: implications and prospects for therapeutics
Signal Transduction and Targeted Therapy, 2022 Molecular oxygen (O 2 ) is essential for most biological reactions in mammalian cells. When the intracellular oxygen content decreases, it is called hypoxia.
Zhen Luo +9 more
semanticscholar +1 more source
Hypoxia and metabolic adaptation of cancer cells [PDF]
Oncogenesis, 2016 AbstractLow oxygen tension (hypoxia) is a pervasive physiological and pathophysiological stimulus that metazoan organisms have contended with since they evolved from their single-celled ancestors. The effect of hypoxia on a tissue can be either positive or negative, depending on the severity, duration and context.
Katherine L. Eales +3 more
openaire +3 more sources
Hypoxia-resistance heterogeneity in tumours: the impact of geometrical characterization of environmental niches and evolutionary trade-offs. A mathematical approach [PDF]
, 2023 In the study of cancer evolution and therapeutic strategies, scientific evidence shows that a key dynamics lies in the tumor-environment interaction. In particular, oxygen concentration plays a central role in the determination of the phenotypic heterogeneity of cancer cell populations, whose qualitative and geometric characteristics are predominant ...
arxiv +1 more source
Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner [PDF]
, 2018 17β-Estradiol (E2) attenuates hypoxia-induced pulmonary hypertension (HPH) through estrogen receptor (ER)-dependent effects, including inhibition of hypoxia-induced endothelial cell proliferation; however, the mechanisms responsible for this remain ...
Albrecht, Marjorie +6 more
core +1 more source
HIF-1 alpha-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion [PDF]
, 2014 © 2014 Landes Bioscience. PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer. Here we demonstrate that cytosolic PTK6 is rapidly and robustly induced in response to hypoxic conditions in a HIF-1-independent manner.
Blokland, Nina J. G. +8 more
core +5 more sources
Hypoxia in Breast Cancer—Scientific Translation to Therapeutic and Diagnostic Clinical Applications
Frontiers in Oncology, 2021 Breast cancer has been the leading cause of female cancer deaths for decades. Intratumoral hypoxia, mainly caused by structural and functional abnormalities in microvasculature, is often associated with a more aggressive phenotype, increased risk of ...
Ying Zhang +13 more
doaj +1 more source