Results 41 to 50 of about 599,693 (212)

HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer.
Blokland, NJG, Broos, AWT, Eccles, SA, Hammond, EM, Harvey, AJ, Pires, IM, Poujade, F-A, Senra, JM, Span, PN   +8 more
core   +4 more sources

Hypoxia enhances the antiglioma cytotoxicity of B10, a glycosylated derivative of betulinic acid. [PDF]

PLoS ONE, 2014
B10 is a glycosylated derivative of betulinic acid with promising activity against glioma cells. Lysosomal cell death pathways appear to be essential for its cytotoxicity.
Sebastian Fischer, Michael W Ronellenfitsch, Anna-Luisa Thiepold, Patrick N Harter, Sebastian Reichert, Donat Kögel, Reinhard Paschke, Michel Mittelbronn, Michael Weller, Joachim P Steinbach, Simone Fulda, Oliver Bähr   +11 more
doaj   +1 more source

Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF‐β Pathway Inhibition

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Marfan syndrome (MFS) is a heritable connective tissue disorder caused by mutations in the Fibrillin‐1 gene, which encodes the extracellular matrix protein fibrillin‐1.
Yuhao Chen, Yuankang Zhu, Xiaoli Ren, Lu Ding, Yubin Xu, Miqi Zhou, Runze Dong, Peifeng Jin, Xiufang Chen, Xiaofang Fan, Ming Li, Yongsheng Gong, Yongyu Wang   +12 more
doaj   +1 more source

Hypoxic pre-conditioning increases the infiltration of endothelial cells into scaffolds for dermal regeneration pre-seeded with mesenchymal stem cells. [PDF]

, 2015
Many therapies using mesenchymal stem cells (MSC) rely on their ability to produce and release paracrine signals with chemotactic and pro-angiogenic activity.
Beegle, Julie R, Chávez, Myra N, Egaña, José T, Fierro, Fernando A, Isseroff, Roslyn R, O'Neal, Adam J, Peavy, Thomas R   +6 more
core   +2 more sources

GBM radiosensitizers: dead in the water…or just the beginning? [PDF]

, 2017
The finding that most GBMs recur either near or within the primary site after radiotherapy has fueled great interest in the development of radiosensitizers to enhance local control.
Bindra, Ranjit S., Chalmers, Anthony J., Dewhirst, Mark, Evans, Sydney   +3 more
core   +1 more source

Comparative and Experimental Studies on the Genes Altered by Chronic Hypoxia in Human Brain Microendothelial Cells

Frontiers in Physiology, 2017
Background : Hypoxia inducible factor 1 alpha (HIF1A) is a master regulator of acute hypoxia; however, with chronic hypoxia, HIF1A levels return to the normoxic levels.
Eugenia Mata-Greenwood, Dipali Goyal, Dipali Goyal, Ravi Goyal, Ravi Goyal   +4 more
doaj   +1 more source

Protection and mechanism of oxygen glucose deprivation exposed astrocytes by nuclear factor⁃erythroid 2⁃related factor 2 signal pathway activation

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To analyze the protective effect and mechanism of nuclear factor⁃erythroid 2⁃related factor 2 (Nrf2) signal pathway agonist tertiary butylhydroquinone (tBHQ) on astrocytes under oxygen glucose deprivation (OGD).
GAO Yu⁃tian, WANG Ke⁃jian, WU Cheng⁃ji, HUANG Zuo⁃yi   +3 more
doaj   +1 more source

Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer [PDF]

, 2016
The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments.
Chalmers, Anthony J., Gomez-Roman, Natividad, McGregor, Fiona, Plumb, Jane   +3 more
core   +1 more source

The impact of hypoxia on B cells in COVID-19

EBioMedicine, 2022
Summary: Background: Prominent early features of COVID-19 include severe, often clinically silent, hypoxia and a pronounced reduction in B cells, the latter important in defence against SARS-CoV-2.
Prasanti Kotagiri, Federica Mescia, Aimee L. Hanson, Lorinda Turner, Laura Bergamaschi, Ana Peñalver, Nathan Richoz, Stephen D. Moore, Brian M. Ortmann, Benjamin J. Dunmore, Michael D. Morgan, Zewen Kelvin Tuong, Berthold Göttgens, Mark Toshner, Christoph Hess, Patrick. H. Maxwell, Menna. R. Clatworthy, James A. Nathan, John R. Bradley, Paul A. Lyons, Natalie Burrows, Kenneth G.C. Smith   +21 more
doaj   +1 more source

The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]

, 2008
Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core   +1 more source