Results 91 to 100 of about 3,494,106 (354)

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Ab initio phenomenological simulation of the growth of large tumor cell populations [PDF]

, 2007
In a previous paper we have introduced a phenomenological model of cell metabolism and of the cell cycle to simulate the behavior of large tumor cell populations (Chignola R and Milotti E, Phys. Biol. 2 (2005) 8-22). Here we describe a refined and extended version of the model that includes some of the complex interactions between cells and their ...
arxiv   +1 more source

Integrative Pan-Cancer Analysis of RNMT: a Potential Prognostic and Immunological Biomarker [PDF]

arXiv, 2022
Background: RNA guanine-7 methyltransferase (RNMT) is one of the main regulators of N7-methylguanosine, and the deregulation of RNMT correlated with tumor development and immune metabolism. However, the specific function of RNMT in pan-cancer remains unclear.
arxiv  

Phenotype of polyoma-induced hamster tumor cells lines [PDF]

Journal of Virology, 1980
Cell lines from polyoma-induced hamster tumors exhibit a fully transformed phenotype despite the absence of the 105K (105,000-dalton) form of polyoma T-antigen.
T Miyamura, Robert H. Pollack, Malcolm A. Martin, Mark A. Israel, Kenneth K. Takemoto, Daniel B. Rifkin   +5 more
openaire   +3 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities

eLife
Air pollution significantly impacts lung cancer progression, but there is a lack of a comprehensive molecular characterization of clinical samples associated with air pollution. Here, we performed a proteogenomic analysis of lung adenocarcinoma (LUAD) in
Honglei Zhang, Chao Liu, Shuting Wang, Qing Wang, Xu Feng, Huawei Jiang, Li Xiao, Chao Luo, Lu Zhang, Fei Hou, Minjun Zhou, Zhiyong Deng, Heng Li, Yong Zhang, Xiaosan Su, Gaofeng Li   +15 more
doaj   +1 more source

TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells [PDF]

, 2019
The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination and migration, tumor circulating cell generation, cancer stem cells, chemoresistance, and metastasis formation.
García Martínez, Jorge, Guerrero Martínez, José A., Gómez Marín, Elena, Reyes Rosa, José Carlos, Rivero Canalejo, Sabrina   +4 more
core   +2 more sources

An NK cell line (haNK) expressing high levels of granzyme and engineered to express the high affinity CD16 allele

OncoTarget, 2016
Natural killer (NK) cells are known to play a role in mediating innate immunity, in enhancing adaptive immune responses, and have been implicated in mediating anti-tumor responses via antibody-dependent cell-mediated cytotoxicity (ADCC) by reactivity of ...
C. Jochems, J. Hodge, M. Fantini, R. Fujii, Y. Maurice, Morillon Ii, J. Greiner, Michelle R. Padget, S. Tritsch, K. Tsang, K. Campbell, H. Klingemann, L. Boissel, S. Rabizadeh, P. Soon-Shiong, J. Schlom   +15 more
semanticscholar   +1 more source

Frequency and distribution of Notch mutations in tumor cell lines [PDF]

BMC Cancer, 2015
Deregulated Notch signaling is linked to a variety of tumors and it is therefore important to learn more about the frequency and distribution of Notch mutations in a tumor context.In this report, we use data from the recently developed Cancer Cell Line Encyclopedia to assess the frequency and distribution of Notch mutations in a large panel of cancer ...
Anders P. Mutvei, Urban Lendahl, Erik Fredlund   +2 more
openaire   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source