Results 81 to 90 of about 10,955,102 (315)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Establishment and characterization of a new intrahepatic cholangiocarcinoma cell line derived from a Chinese patient

Cancer Cell International, 2022
Patients with intrahepatic cholangiocarcinoma (ICC) require chemotherapy due to late detection, rapid disease progression, and low surgical resection rate.
Xin Miao, Jinjing Hu, Changpeng Chai, Huan Tang, Zhenjie Zhao, Wei Luo, Wence Zhou, Hao Xu   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

SWI/SNF Complex Prevents Lineage Reversion and Induces Temporal Patterning in Neural Stem Cells [PDF]

, 2014
Members of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in human cancer, but how they suppress tumorigenesis is currently unclear.
Knoblich, Juergen A., Reichert, Heinrich, Burkard, Thomas R., Saini, Nidhi, Eroglu, Elif, Homem, Catarina C. F., Jiang, Yanrui, Knoblich JA, Burkard, TR, Homem, CCF, Saini N, Jiang, Y, Homem CCF, Burkard TR, Knoblich, JA, Eroglu E, Saini, N, Jiang Y, Reichert H, Eroglu, E, Reichert, H   +20 more
core   +1 more source

Disconnected circadian and cell cycles in a tumor-driven cell line

Communicative & Integrative Biology, 2010
Cell division occurs at a specific time of day in numerous species, suggesting that the circadian and cell cycles are coupled in vivo. By measuring the cell cycle rhythm in real-time, we recently showed that the circadian and cell cycles are not coupled in immortalized fibroblasts, resulting in a rapid rate of cell division even though the circadian ...
Julie S. Pendergast, Mijung Yeom, Bryan A. Reyes, Yoshihiro Ohmiya, Shin Yamazaki   +4 more
openaire   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Tumor initiating ability in colon cancer cell line.

, 2016
Tumor initiating ability in colon cancer cell line.
Yoshihiko Hirohashi (93294), Takayuki Kanaseki (482424), Aiko Murai (683051), Toshihiko Torigoe (93291), Tomohide Tsukahara (482423), Toru Kondo (260536), Munehide Nakatsugawa (482427), Yasuaki Tamura (482422), Akari Takaya (3153549), Noriyuki Sato (93300), Hiroshi Saijo (482425), Eri Yamamoto (2317756), Ichiro Takemasa (1607), Rena Morita (418953), Terufumi Kubo (482426)   +14 more
core   +1 more source

Somatic gene therapy for cancer. The utility of transferrinfection in generating ‘tumor vaccines’ [PDF]

, 1993
The last few years have seen the development of a branch of somatic gene therapy which aims at strengthening the immune surveillance of the body, leading to eradication of disseminated cancer tumor cells and occult micrometastases after surgical removal ...
Zatloukal, Kurt, Stingl, Georg, Schmidt, Walter, Cotten, Matthew, Wagner, Ernst, Birnstiel, Max L., Cotten, Matt   +6 more
core   +1 more source

Synergistic Antiproliferative Effects of Chondroitin Sulfate and Fucoidan in Tumor-derived Spheroids: Insights From a 3D Cell Culture Approach

European Pharmaceutical Journal
The aim of the study was to investigate the effects of chondroitin sulfate (CS) and fucoidan (F), as well as their combination (CS + F) on the growth and viability of spheroids derived from the non-tumor cell line NIH3T3 and the tumor cell line Hepa1c1c7
Nováková E, Zima J, Špaglová M, Labudová M, Šupolíková M   +4 more
doaj   +1 more source

BIOGUIDED FRACTIONATION FROM Solanum elaeagnifolium TO EVALUATE TOXICITY ON CELLULAR LINES AND BREAST TUMOR EXPLANTS

Vitae
Background: Bioactive compounds from the fruit of S. elaeagnifolium were isolated since could be highly potential source to develop functional foods or pharmaceutical products.
Leobardo HERNÁNDEZ O, Pilar CARRANZA R, Luis Enrique COBOS P, Lluvia Itzel LÓPEZ L, Juan Alberto ASCASIO V, Sonia Yesenia SILVA B   +5 more
doaj   +1 more source