Results 91 to 100 of about 1,162,957 (316)

3d Cell-selex: Development Of Rna Aptamers As Molecular Probes For Pc-3 Tumor Cell Line

, 2017
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Human prostate cancer (PCa) is a highly heterogeneous and multifactorial disease.
Marcio J.; Bastos, Luiz R.; Goulart, Vivian A., Souza, Patricia T.; Alves, Karina; Fujimura, Victor Alexandre F.; Goulart, Patricia T.; Silva, Aline G.; Marangoni   +8 more
core   +2 more sources

Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities

eLife
Air pollution significantly impacts lung cancer progression, but there is a lack of a comprehensive molecular characterization of clinical samples associated with air pollution. Here, we performed a proteogenomic analysis of lung adenocarcinoma (LUAD) in
Honglei Zhang, Chao Liu, Shuting Wang, Qing Wang, Xu Feng, Huawei Jiang, Li Xiao, Chao Luo, Lu Zhang, Fei Hou, Minjun Zhou, Zhiyong Deng, Heng Li, Yong Zhang, Xiaosan Su, Gaofeng Li   +15 more
doaj   +1 more source

Establishment and characterization ofmouse hepatic tumor cell line with luc2-tdT expression [PDF]

Jichu yixue yu linchuang
Objective The mouse autologous tumor model H22 is more valuable for tumor immunological-related research. This paper aims to establish mouse hepatic tumor cell line (H22-luc2-tdT)that stably express the tandem-dimer tomato(tdTomato) and luciferase genes.
HAO Sijia, YANG Zhenli, BIAN Xiaocui, HOU Yuhong, LIU Yuqin
doaj   +1 more source

Establishment and characterization of a new intrahepatic cholangiocarcinoma cell line derived from a Chinese patient

Cancer Cell International, 2022
Patients with intrahepatic cholangiocarcinoma (ICC) require chemotherapy due to late detection, rapid disease progression, and low surgical resection rate.
Xin Miao, Jinjing Hu, Changpeng Chai, Huan Tang, Zhenjie Zhao, Wei Luo, Wence Zhou, Hao Xu   +7 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Effect of Dexamethasone on Cell Proliferation of Neuroepithelial Tumor Cell Lines.

Neurologia medico-chirurgica, 1998
The effect of glucocorticoid on cell proliferation, the expression of glucocorticoid receptor, and the relationship between inhibition of cell growth and apoptosis were investigated in four established neuroepithelial tumor cell lines (KNS42, T98G, A172, and U251MG).
KAWAMURA, Atsufumi, TAMAKI, Norihiko, KOKUNAI, Takashi   +2 more
openaire   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers [PDF]

, 2003
Objectives: Our study sought to elucidate the role of oxidative stress for shedding of tumor necrosis factor-α (TNF-α) and for activating TNF-α-converting enzyme (TACE).
Welsch, Ulrich, Sommerhoff, Christian P., Gilles, Stefanie, Zahler, Stefan, Becker, Bernhard F.   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Synergistic Antiproliferative Effects of Chondroitin Sulfate and Fucoidan in Tumor-derived Spheroids: Insights From a 3D Cell Culture Approach

European Pharmaceutical Journal
The aim of the study was to investigate the effects of chondroitin sulfate (CS) and fucoidan (F), as well as their combination (CS + F) on the growth and viability of spheroids derived from the non-tumor cell line NIH3T3 and the tumor cell line Hepa1c1c7
Nováková E, Zima J, Špaglová M, Labudová M, Šupolíková M   +4 more
doaj   +1 more source