Results 71 to 80 of about 10,955,102 (315)

Feeding, Fear, and Acceptance: Caregivers’ Experiences of Nutritional Support During Childhood Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose To explore caregivers' experiences and perceptions of the nutritional challenges faced by children and adolescents undergoing cancer treatment, including oral intake and the use of nutritional support. Methods This was a qualitative study based on focus groups with parents and caregivers at a Brazilian pediatric oncology hospital ...
Danyelle Apparecida Balsamão Marques, Mariana dos Santos Murra, Welinton Hirai, Ana Laura Balduino do Nascimento, Karla Emilia de Sá Rodrigues, Wilson Elias de Oliveira Junior   +5 more
wiley   +1 more source

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source

Role of p52 (NF-κB2) in LPS tolerance in a human B cell line [PDF]

, 1999
Cells of the weakly CD14 positive human B cell line RPMI 8226, clone 1, will mobilize NF-κB (p50/p65 and p50/p50) proteins and produce TNF mRNA when stimulated with lipopolysaccharide (LPS), When such cells are precultured with a low amount of LPS (50 ...
Wedel, Angela, Sulski, Gabi, Kuprash, Dmitry, H.W. Loems Ziegler-Heitbrock, Angela Wedel, Marion Frankenberger, Irmhild Petersmann, Nedospasov, Sergei, Frankenberger, Marion, Petersmann, Irmhild, Ziegler-Heitbrock, H. W. Loems, Dmitry Kuprash, Sergei Nedospasov, Gabi Sulski   +13 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

miR-140-5p Alleviates The Aggressive Progression Of Wilms’ Tumor Through Directly Targeting TGFBR I Gene [Retraction]

Cancer Management and Research, 2019
Wang H, Lou C, Ma N. miR-140-5p alleviates the aggressive progression of Wilms’ tumor through directly targeting TGFBR I gene. Cancer Manage Res.
Wang H, Lou C, Ma N
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Establishment and characterization ofmouse hepatic tumor cell line with luc2-tdT expression [PDF]

Jichu yixue yu linchuang
Objective The mouse autologous tumor model H22 is more valuable for tumor immunological-related research. This paper aims to establish mouse hepatic tumor cell line (H22-luc2-tdT)that stably express the tandem-dimer tomato(tdTomato) and luciferase genes.
HAO Sijia, YANG Zhenli, BIAN Xiaocui, HOU Yuhong, LIU Yuqin
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities

eLife
Air pollution significantly impacts lung cancer progression, but there is a lack of a comprehensive molecular characterization of clinical samples associated with air pollution. Here, we performed a proteogenomic analysis of lung adenocarcinoma (LUAD) in
Honglei Zhang, Chao Liu, Shuting Wang, Qing Wang, Xu Feng, Huawei Jiang, Li Xiao, Chao Luo, Lu Zhang, Fei Hou, Minjun Zhou, Zhiyong Deng, Heng Li, Yong Zhang, Xiaosan Su, Gaofeng Li   +15 more
doaj   +1 more source

Effect of Dexamethasone on Cell Proliferation of Neuroepithelial Tumor Cell Lines.

Neurologia medico-chirurgica, 1998
The effect of glucocorticoid on cell proliferation, the expression of glucocorticoid receptor, and the relationship between inhibition of cell growth and apoptosis were investigated in four established neuroepithelial tumor cell lines (KNS42, T98G, A172, and U251MG).
KAWAMURA, Atsufumi, TAMAKI, Norihiko, KOKUNAI, Takashi   +2 more
openaire   +3 more sources