Results 51 to 60 of about 10,955,102 (315)

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Targeting the extra domain A of fibronectin for cancer therapy with CAR-T cells

Journal for ImmunoTherapy of Cancer, 2022
Background One of the main difficulties of adoptive cell therapies with chimeric antigen receptor (CAR)-T cells in solid tumors is the identification of specific target antigens.
Felipe Prosper, Sandra Hervás-Stubbs, Juan Jose Lasarte, Noelia Casares, Teresa Lozano, Diego Serrano, Carlos E De Andrea, Alfonso Calvo, Enrique Conde, Celia Martín-Otal, Aritz Lasarte-Cia, Flor Navarro, Inés Sánchez-Moreno, Marta Gorraiz, Patricia Sarrión, José Echeveste, Amaia Vilas, Juan Roberto Rodriguez-Madoz, Jesús San Miguel   +18 more
doaj   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]

, 2013
Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core  

A-Disintegrin and metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells [PDF]

, 2012
It has been proposed that gliomas contain a subpopulation of 'Brain Tumor Stem Cells' (BTSCs), which demonstrate resistance to conventional therapies.
Siney, Elodie J, Sampson, Jessica M., Sampson, Jessica M, Jones, Louise M, Bulstrode, Harry, Siney, Elodie J., Gray, William Peter, Ludwig, Andreas, Willaime-Morawek, Sandrine, Gray, William P, Jones, Louise M., Gray, William P.   +11 more
core   +1 more source

Evaluation of engraftment and growth dynamics of orthotopic and heterotopic in vivo models of human breast cancer

Южно-Российский онкологический журнал
Purpose of the study. This work was to assess the engraftment and growth dynamics of breast cancer xenografts during orthotopic and subcutaneous injection using various types of biological material, as well as to develop an adequate model of breast ...
I. S. Lyashenko, M. V. Romanova, A. S. Goncharova, D. V. Khodakova, A. V. Galina, S. V. Gurova, S. Yu. Filippova, Yu. S. Shatova   +7 more
doaj   +1 more source

Establishment and characterization of a cell line HCS1220 from human liver metastasis of colon cancer

Cancer Cell International, 2018
Background To establish one primary cell line of human liver metastasis of colon cancer. Methods HCS1220 cell line was derived from one liver metastasis of colon cancer patient’s resected tumor sample. The characterization of the cell line was defined by
Yi Chai, Huan Wang, Fang Zhou
doaj   +1 more source

Identification and validation of expressed HLA-binding breast cancer neoepitopes for potential use in individualized cancer therapy

Journal for ImmunoTherapy of Cancer, 2021
Background Therapeutic regimens designed to augment the immunological response of a patient with breast cancer (BC) to tumor tissue are critically informed by tumor mutational burden and the antigenicity of expressed neoepitopes.
Jeffrey Schlom, James L Gulley, Andrew Nguyen, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong, Duane H Hamilton, Marieke Griffioen, Andreas Mackensen, Stephen C Benz, Patricia Spilman, Peter A Fasching, Matthias W Beckmann, Alexander Hein, Matthias Ruebner, Hannah Reimann, J Zachary Sanborn, Charles J Vaske, Edith D van der Meijden, Judith Bausenwein, Sascha Kretschmann, Karin L Lee, Anita N. Kremer   +22 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

UBE2QL1 is Disrupted by a Constitutional Translocation Associated with Renal Tumor Predisposition and is a Novel Candidate Renal Tumor Suppressor Gene [PDF]

, 2013
Investigation of rare familial forms of renal cell carcinoma (RCC) has led to the identification of genes such as VHL and MET that are also implicated in the pathogenesis of sporadic RCC. In order to identify a novel candidate renal tumor suppressor gene,
Hodgson, S, Morris, Mark R., Turnell, Andrew S., Woodward, ER, Prigmore, Elena, Woodward, Emma R.; id_orcid, Wake, NC, Wake, Naomi C., Gribble, Susan M., Ricketts, Christopher J., Skytte, AB, Brown, Michael, Banks, RE, Morris, MR, Prigmore, E, Maher, ER, Woodward, Emma R., Clarke, Noel, Hodgson, Shirley, Skytte, Anne-bine, Ricketts, CJ, Turnell, AS, Brown, Michael; id_orcid, Maher, Eamonn R., Clarke, N, Banks, Rosamonde E., Gribble, SM, Brown, M, Skytte, Anne Bine, Wake, N, Clarke, Noel W, Brown, Michael D, Ricketts, C, Woodward, E, Skytte, A-B, Maher, E, Morris, M, Banks, R, Turnell, A, Gribble, S   +39 more
core   +1 more source