Results 31 to 40 of about 10,432,298 (311)
Biomedicines, 2022 The host defense derived peptide was assessed in different model systems with increasing complexity employing the highly aggressive NRAS mutated melanoma metastases cell line MUG-Mel2.
Maximiliane Wußmann +9 more
doaj +1 more source
Absence of ST7 mutations in tumor-derived cell lines and tumors
Nature Genetics, 2001 The gene ST7 has been proposed as the multi-tissue tumor-suppressor gene (TSG) at chromosome 7q31.1. However, we have sought and failed to detect the truncating mutations reported to exist in this gene.
Hughes, Kate A. +4 more
openaire +4 more sources
The Role of Cell Lines in the Study of Neuroendocrine Tumors [PDF]
Neuroendocrinology, 2012 Cell lines originating from neuroendocrine tumors (NETs) represent useful experimental models to assess the control of synthesis and release of different hormones and hormone-like peptides, to evaluate the mechanisms of action of these agents in target tissues at the cellular and subcellular levels, and to study cell proliferation and tumor development,
Simona, Grozinsky-Glasberg +2 more
openaire +2 more sources
New molecular mediators in tumor angiogenesis [PDF]
, 2007 Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Jonas, Dietger +2 more
core +1 more source
Role of p52 (NF-κB2) in LPS tolerance in a human B cell line [PDF]
, 1999 Cells of the weakly CD14 positive human B cell line RPMI 8226, clone 1, will mobilize NF-κB (p50/p65 and p50/p50) proteins and produce TNF mRNA when stimulated with lipopolysaccharide (LPS), When such cells are precultured with a low amount of LPS (50 ...
Wedel, Angela +13 more
core +1 more source
Nanomaterials, 2023 Multidrug resistance (MDR) is the main challenge in cancer treatment. In this sense, we designed transferrin (Tf)-conjugated PLGA nanoparticles (NPs) containing an organoselenium compound as an alternative to enhance the efficacy of cancer therapy and ...
Letícia Bueno Macedo +8 more
doaj +1 more source
Generation of Luciferase-expressing Tumor Cell Lines
BIO-PROTOCOL, 2018 Murine tumor models have been critical to advances in our knowledge of tumor physiology and for the development of effective tumor therapies. Essential to these studies is the ability to both track tumor development and quantify tumor burden in vivo. For this purpose, the introduction of genes that confer tumors with bioluminescent properties has been ...
Todd Brennan +3 more
openaire +4 more sources
Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen. [PDF]
, 2012 A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progenitor ...
Georg Enders (187983) +32 more
core +1 more source
Functional validation of cancer stem cell markers in primary human colorectal cancer and established cell lines [PDF]
, 2014 In an increasing number of cancers, CSCs have been defined on the basis of the self-renewal and tumor initiation capacity by functional assays. It has been also suggested that CSC populations might be responsible for chemo- and radio-therapy resistance ...
Muraro, Manuele Giuseppe
core +1 more source
Mechanisms of Rejection of High Grade B cell Lymphoma in Mice [PDF]
, 2008 The incidence of high grade B cell lymphoma in western countries has increased over the last decades. Improvement of conventional chemotherapy regimens has significantly contributed to prolonged 5-year survival rates which currently reach around 60 ...
Sukumar, Madhusudhanan
core +1 more source