Results 31 to 40 of about 10,955,102 (315)

Absence of ST7 mutations in tumor-derived cell lines and tumors

Nature Genetics, 2001
The gene ST7 has been proposed as the multi-tissue tumor-suppressor gene (TSG) at chromosome 7q31.1. However, we have sought and failed to detect the truncating mutations reported to exist in this gene.
Hughes, Kate A., Hurlstone, Adam F L; id_orcid 0000-0001-5260-9457, Tobias, Edward S., McFarlane, Robert, Black, Donald M.   +4 more
openaire   +4 more sources

New molecular mediators in tumor angiogenesis [PDF]

, 2007
Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Jonas, Dietger, Beecken, Wolf-Dietrich, Kramer, Wolfgang   +2 more
core   +1 more source

Transferrin-Decorated PLGA Nanoparticles Loaded with an Organoselenium Compound as an Innovative Approach to Sensitize MDR Tumor Cells: An In Vitro Study Using 2D and 3D Cell Models

Nanomaterials, 2023
Multidrug resistance (MDR) is the main challenge in cancer treatment. In this sense, we designed transferrin (Tf)-conjugated PLGA nanoparticles (NPs) containing an organoselenium compound as an alternative to enhance the efficacy of cancer therapy and ...
Letícia Bueno Macedo, Daniele Rubert Nogueira-Librelotto, Daniela Mathes, Taís Baldissera Pieta, Micheli Mainardi Pillat, Raquel Mello da Rosa, Oscar Endrigo Dorneles Rodrigues, Maria Pilar Vinardell, Clarice Madalena Bueno Rolim   +8 more
doaj   +1 more source

Generation of Luciferase-expressing Tumor Cell Lines

BIO-PROTOCOL, 2018
Murine tumor models have been critical to advances in our knowledge of tumor physiology and for the development of effective tumor therapies. Essential to these studies is the ability to both track tumor development and quantify tumor burden in vivo. For this purpose, the introduction of genes that confer tumors with bioluminescent properties has been ...
Todd Brennan, Liwen Lin, Xiaopei Huang, Yiping Yang   +3 more
openaire   +4 more sources

Exploring functional mechanisms underlying tumor initiation, EMT and cell migration [PDF]

, 2012
Cancer is one of the leading causes of death. A primary tumor forms when cells start to proliferate in an uncontrolled way and stop reacting to restraining signals.
Gruber, Dorothea Cornelia
core   +1 more source

Establishment of a Novel IDH1 wild type Glioblastoma Cell Line, SHG142, and Its Organoids

Frontiers in Bioscience-Landmark
Background: Glioblastoma (GBM) is the most aggressive primary malignant brain tumor and is associated with limited treatment options and poor prognosis.
Heyang Gao, Hao Wang, Lin Yao, Guozheng Zhao, Liyan Tang, Xiao Zhang, Jialiang Qian, Xiyang Weng, Youxin Zhou   +8 more
doaj   +1 more source

Experimental Adaptation of Rotaviruses to Tumor Cell Lines

PLOS ONE, 2016
A number of viruses show a naturally extended tropism for tumor cells whereas other viruses have been genetically modified or adapted to infect tumor cells. Oncolytic viruses have become a promising tool for treating some cancers by inducing cell lysis or immune response to tumor cells. In the present work, rotavirus strains TRF-41 (G5) (porcine), RRV (
Carlos A Guerrero, Rafael A Guerrero, Elver Silva, Orlando Acosta, Emiliano Barreto   +4 more
openaire   +4 more sources

Pituitary tumor-transforming gene expression is a prognostic marker for tumor recurrence in squamous cell carcinoma of the head and neck [PDF]

, 2006
Background The proto-oncogene pituitary tumor-transforming gene (PTTG) has been shown to be abundantly overexpressed in a large variety of neoplasms likely promoting neo-vascularization and tumor invasiveness.
Solbach, Christine, Peters Silke, Eckerdt, Frank, Peters, Silke, Knecht, Rainald, Roller, Marc, Roller Marc, Eckerdt Frank, Solbach Christine, Knecht Rainald, Marc Roller, Frank Eckerdt, Rainald Knecht, Silke Peters, Christine Solbach   +14 more
core   +2 more sources

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition [PDF]

, 2021
Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features underpinning CPI sensitization.
Turati, Virginia, Rosenthal, R, Saini, SK, Rosenthal, Rachel, Herrero, Javier, Rowan, A, Turajlic, Samra, Litchfield, K, Guerra-Assunção, José Afonso, Turajlic, S, Hellmann, Matthew D., Swanton, C, Saini, Sunil Kumar, Larkin, James, McGranahan, Nicholas, Reading, JL, Puttick, C, Reading, James L., Swanton, Charles, Thakkar, K, Al Bakir, M, Conde, L, Lim, Emilia, Watkins, TBK, Biswas, D, Enver, Tariq, Puttick, Clare, Turati, V, Litchfield, Kevin, Watkins, Thomas B.K., Hellmann, MD, Rowan, Andrew, Lim, E, Biswas, Dhruva, Van Loo, P, Quezada, SA, Guerra-Assunção, JA, Quezada, Sergio A., Bentham, Robert, Herrero, J, Enver, T, Furness, Andrew J.S., Hadrup, Sine R., Conde, Lucia, Hadrup, SR, Abbosh, C, Lee, Se Hoon, Furness, AJS, Lee, S-H, Al Bakir, Maise, Abbosh, Chris, McGranahan, N, Bentham, R, Larkin, J, Van Loo, Peter, Thakkar, Krupa, James L. Reading, Sunil Kumar Saini, Samra Turajlic, Maise Al Bakir, Nicholas McGranahan, Rachel Rosenthal, Kevin Litchfield, Matthew D. Hellmann, José Afonso Guerra-Assunção, Charles Swanton, Dhruva Biswas, Tariq Enver, Andrew Rowan, Sergio A. Quezada, Lucia Conde, Andrew J.S. Furness, Krupa Thakkar, Virginia Turati, Se-Hoon Lee, James Larkin, Javier Herrero, Robert Bentham, Peter Van Loo, Clare Puttick, Emilia Lim, Chris Abbosh, Sine R. Hadrup, Thomas B.K. Watkins   +83 more
core   +1 more source

Intracranial transplantation of the tumor induced by adenovirus type 12 in Syrian hamster--an experimental brain tumor model [PDF]

, 1971
A method of intracranial transplantation of the tumor induced by adenovirus type 12 in syrian hamster has been described. The incidence of intracranial tumor development was 86 (90.5 %) out of 95 animals and the average survival time and tumor size at ...
Tabuchi, Kazuo
core   +1 more source