Results 31 to 40 of about 1,625,980 (311)

Thrombopoietin Receptor Levels in Tumor Cell Lines and Primary Tumors [PDF]

Journal of Oncology, 2010
Thrombopoietin (TPO) receptor agonists represent a new approach for the treatment of thrombocytopenia, which may develop as a consequence of immune thrombocytopenia, chemotherapy treatment, chronic hepatitis C infection, or myelodysplastic syndromes. There are concerns that use of certain growth factors can hasten disease progression in some types of ...
Erickson-Miller, Connie L., Chadderton, Antony, Gibbard, Anna, Kirchner, Jennifer, Pillarisetti, Kodandaram, Baker, Katherine, Pandite, Lini, El-Hariry, Iman, Mostafa Kamel, Yasser, Liu, Yuan, Martin, Anne-Marie, Messam, Conrad   +11 more
openaire   +2 more sources

Overexpression of microRNA-16 declines cellular growth, proliferation and induces apoptosis in human breast cancer cells [PDF]

, 2015
MicroRNAs (miRNA) are a large family of small single-stranded RNA molecules found in all multicellular organisms. Early studies have been shown that miRNA are involved in cancer development and progression, and this role can be done by working as an ...
Hafizi, M., kouhkan, F., Mobarra, N., Movahed, M., Rad, S.M.A.H., Shafiee, A., Soleimani, M., Soufi-zomorod, M., Tasharrofi, N.   +8 more
core   +2 more sources

Establishment of a Novel IDH1 wild type Glioblastoma Cell Line, SHG142, and Its Organoids

Frontiers in Bioscience-Landmark
Background: Glioblastoma (GBM) is the most aggressive primary malignant brain tumor and is associated with limited treatment options and poor prognosis.
Heyang Gao, Hao Wang, Lin Yao, Guozheng Zhao, Liyan Tang, Xiao Zhang, Jialiang Qian, Xiyang Weng, Youxin Zhou   +8 more
doaj   +1 more source

Ablative and Immunostimulatory Effects of Histotripsy Ablation in a Murine Osteosarcoma Model

Biomedicines, 2023
Background: Osteosarcoma (OS) is the most frequently occurring malignant bone tumor in humans, primarily affecting children and adolescents. Significant advancements in treatment options for OS have not occurred in the last several decades, and the ...
Alayna N. Hay, Khan Mohammad Imran, Alissa Hendricks-Wenger, Jessica M. Gannon, Jacqueline Sereno, Alex Simon, Victor A. Lopez, Sheryl Coutermarsh-Ott, Eli Vlaisavljevich, Irving C. Allen, Joanne L. Tuohy   +10 more
doaj   +1 more source

TBL1 is required for the mesenchymal phenotype of transformed breast cancer cells [PDF]

, 2019
The epithelial-to-mesenchymal transition (EMT) and its reversion (MET) are related to tumor cell dissemination and migration, tumor circulating cell generation, cancer stem cells, chemoresistance, and metastasis formation.
García Martínez, Jorge, Guerrero Martínez, José A., Gómez Marín, Elena, Reyes Rosa, José Carlos, Rivero Canalejo, Sabrina   +4 more
core   +2 more sources

Duplex DNA from Sites of Helicase-Polymerase Uncoupling Links Non-B DNA Structure Formation to Replicative Stress [PDF]

, 2020
BACKGROUND: Replication impediments can produce helicase-polymerase uncoupling allowing lagging strand synthesis to continue for as much as 6 kb from the site of the impediment.
Abdelhamid, Mahmoud A S, Amparo, Camille, Bedell, Victoria, Clark, Jarrod, Martella, Marianna, Murata-Collins, Joyce L, Pichiorri, Flavia, Smith, Steven S, Waller, Zoë A E, Warner, Emily F   +9 more
core   +2 more sources

Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector. [PDF]

, 2014
A tumor-selective non-lytic retroviral replicating vector (RRV), Toca 511, and an extended-release formulation of 5-fluorocytosine (5-FC), Toca FC, are currently being evaluated in clinical trials in patients with recurrent high-grade glioma (NCT01156584,
Gruber, Harry E, Hiraoka, Kei, Inagaki, Akihito, Iwamoto, Keisuke S, Jolly, Douglas J, Kamijima, Shuichi, Kasahara, Noriyuki, McBride, William H, Micewicz, Ewa, Robbins, Joan M, Takahashi, Masamichi, Valdes, Gilmer   +11 more
core   +2 more sources

Exquisite Tumor Targeting by Salmonella A1-R in Combination with Caffeine and Valproic Acid Regresses an Adult Pleomorphic Rhabdomyosarcoma Patient-Derived Orthotopic Xenograft Mouse Model. [PDF]

, 2020
Adult pleomorphic rhabdomyosarcoma (RMS) is a rare and malignant mesenchymal tumor. Recently, we developed a patient-derived orthotopic xenograft (PDOX) model of adult pleomorphic RMS.
Dry, Sarah M, Hayashi, Katsuhiro, Higuchi, Takashi, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kimura, Hiroaki, Kiyuna, Tasuku, Li, Yunfeng, Miwa, Shinji, Miyake, Kentaro, Miyake, Masuyo, Nelson, Scott D, Singh, Shree Ram, Tsuchiya, Hiroyuki, Yamamoto, Norio, Zhao, Ming   +16 more
core  

Generation of Luciferase-expressing Tumor Cell Lines

BIO-PROTOCOL, 2018
Murine tumor models have been critical to advances in our knowledge of tumor physiology and for the development of effective tumor therapies. Essential to these studies is the ability to both track tumor development and quantify tumor burden in vivo. For this purpose, the introduction of genes that confer tumors with bioluminescent properties has been ...
Todd Brennan, Liwen Lin, Xiaopei Huang, Yiping Yang   +3 more
openaire   +4 more sources

A cell line derived from BBN (N-butyl-N-[4-hydroxybutyl]-nitrosamine)-induced rat bladder cancer: establishment and scanning electron microscopic cell surface characteristics [PDF]

, 1978
This research was performed to establish a cell line from experimental bladder tumor and to discuss the biological characteristics of the cell line so established. Tissue cultures of epithelial cells were derived from a rat bladder cancer induced by BBN.
Nishi, Mitsuo
core   +1 more source