Results 11 to 20 of about 1,118,590 (267)
RB activation defect in tumor cell lines [PDF]
Proceedings of the National Academy of Sciences, 2002 Activation of the retinoblastoma (RB) protein through dephosphorylation arises in cells upon exit from M phase and in response to environmental stresses, including DNA damage. We provide here for the first time evidence that these responses are co-ordinately affected in a subset of tumor derived cell lines.
Cristina, Broceño +2 more
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Cell lines from circulating tumor cells
Oncoscience, 2015 Circulating tumor cells (CTCs) in the blood of cancer patients have received increasing attention as new diagnostic tool enabling “liquid biopsies” [1]. The perspective to avoid invasive tissue biopsies in the future and obtain similar or even more information by a “simple” blood test has enormous implications in cancer diagnostics [2].
Klaus, Pantel +1 more
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The secret lives of cancer cell lines
Disease Models & Mechanisms, 2018 The extent of genetic and epigenetic diversity between and within patient tumors is being mapped in ever more detail. It is clear that cancer is an evolutionary process in which tumor cell intrinsic and extrinsic forces shape clonal selection.
Robert E. Hynds +2 more
doaj +1 more source
Different toxic effects of YTX in tumor K-562 and lymphoblastoid cell lines
Frontiers in Pharmacology, 2015 Yessotoxin (YTX) modulates cellular phosphodiesterases (PDEs). In this regard, opposite effects had been described in the tumor model K-562 cell line and fresh human lymphocytes in terms of cell viability, cyclic adenosine 3´,5´-cyclic monophosphate ...
Andrea Fernández Araújo +4 more
doaj +1 more source
Journal of Ovarian Research, 2013 Background Cell lines are very useful for clinical and basic research. Thus far, only 11 reports have documented the characteristics of ovarian endometrioid adenocarcinoma cell lines in the literature.
Yamada Takashi +5 more
doaj +1 more source
Establishment and Characterization of A Human Lung Adenocarcinoma Cell Line, Ch-Huang-1
Chinese Journal of Lung Cancer, 2012 Background and objective Lung cancer is a major worldwide health problem. The aim of this study is to establish a novel Chinese human lung adenocarcinoma cell line and examine its biological characteristics.
Bailing LI +6 more
doaj +1 more source
Global computational alignment of tumor and cell line transcriptional profiles
Nature Communications, 2021 The determination of whether cancer cell lines recapitulate the molecular features of corresponding patient tumours remains essential for the selection of appropriate cell line models for preclinical studies.
Allison Warren +8 more
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5-Azacytidine Enhancing Expression of E-cadherin in Adenocarcinoma Cell Line
Archives of Advances in Biosciences, 2023 Introduction: In this study, we assessed the expression of E-cadherin in HT29 cell line treated with 5-Azacytidine and colorectal cancer patient in an Iranian population. E-cadherin expression promotes metastasis and prognosis of colorectal cancer (CRC).
Sanaz Savabkar +4 more
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Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor. [PDF]
PLoS ONE, 2013 Pheochromocytomas are rare tumors generally arising in the medullary region of the adrenal gland. These tumors release excessive epinephrine and norepinephrine resulting in hypertension and cardiovascular crises for which surgery is the only definitive ...
Hans K Ghayee +17 more
doaj +1 more source
Absence of ST7 mutations in tumor-derived cell lines and tumors
Nature Genetics, 2001 The gene ST7 has been proposed as the multi-tissue tumor-suppressor gene (TSG) at chromosome 7q31.1. However, we have sought and failed to detect the truncating mutations reported to exist in this gene.
Hughes, Kate A. +4 more
openaire +4 more sources