Results 11 to 20 of about 18,536,823 (334)
Effective flow-through polishing strategies for knob-into-hole bispecific antibodies
Bioresources and Bioprocessing, 2022 Bispecific antibodies (bsAbs), though possessing great therapeutic potential, are extremely challenging to obtain at high purity within a limited number of scalable downstream processing steps.
Serene W. Chen +4 more
doaj +1 more source
Frontiers in Veterinary Science, 2021 Osteosarcoma (OSA) represents the most common primary bone tumor in dogs and is characterized by a highly aggressive behavior. Cell lines represent one of the most suitable and reproducible pre-clinical models, and therefore the knowledge of their ...
Cecilia Gola +8 more
doaj +1 more source
Bioresources and Bioprocessing, 2022 Bispecific antibodies (bsAbs) are therapeutically promising due to their ability to bind to two different antigens. However, the bsAb byproducts and impurities, including mispaired homodimers, half-antibodies, light chain mispairings, antibody fragments ...
Serene W. Chen +4 more
doaj +1 more source
Development and characterization of a new human hepatic cell line [PDF]
, 2015 The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines.
Berx, Geert +6 more
core +3 more sources
The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity
Nature, 2012 The systematic translation of cancer genomic data into knowledge of tumour biology and therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust preclinical model systems that reflect the genomic diversity of human ...
J. Barretina +60 more
semanticscholar +1 more source
Frontiers in Veterinary Science, 2021 Canine malignant mammary tumor is a dangerously fatal neoplastic disease with poor survival in female dogs. The aim of this study was to preliminary characterize a novel canine mammary cancer cell line, B-CMT, from canine primary mammary gland tumor, and
Rifei Li +6 more
doaj +1 more source
Cell line name recognition in support of the identification of synthetic lethality in cancer from text [PDF]
, 2015 Motivation: The recognition and normalization of cell line names in text is an important task in biomedical text mining research, facilitating for instance the identification of synthetically lethal genes from the literature.
Ginter, Filip +5 more
core +2 more sources
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
Journal of Cell Biology, 1988 In contrast to mouse epidermal cells, human skin keratinocytes are rather resistant to transformation in vitro. Immortalization has been achieved by SV40 but has resulted in cell lines with altered differentiation.
P. Boukamp +5 more
semanticscholar +1 more source
Frontiers in Veterinary Science, 2022 Canine inflammatory mammary carcinoma (CIMC) is a type of canine malignant mammary tumor with a poor prognosis and high mortality. We transduced firefly luciferase and enhanced green fluorescent protein (EGFP) into CHMp, a CIMC cell line, and established
Fangying Zhao +5 more
doaj +1 more source
Minimum Cell Connection in Line Segment Arrangements [PDF]
, 2017 We study the complexity of the following cell connection problems in segment arrangements. Given a set of straight-line segments in the plane and two points a and b in different cells of the induced arrangement: [(i)] compute the minimum number of ...
Alt, H. +3 more
core +2 more sources