Results 41 to 50 of about 2,773,088 (322)
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Journal of Translational MedicineSarcomas, malignant tumors from mesenchymal tissues, exhibit poor prognosis despite advancements in treatment modalities such as surgery, radiotherapy, and chemotherapy, with doxorubicin being a cornerstone treatment.
Young-Eun Cho +4 more
doaj +1 more source
Open Biology, 2022 The diploid anuran Xenopus tropicalis has emerged as a key research model in cell and developmental biology. To enhance the usefulness of this species, we developed methods for generating immortal cell lines from Nigerian strain (NXR_1018, RRID ...
Gary J. Gorbsky +8 more
doaj +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Stem cell population asymmetry can reduce rate of replicative aging [PDF]
Journal of Theoretical Biology 331 (2013) 19-27, 2012 Cycling tissues such as the intestinal epithelium, germ line, and hair follicles, require a constant flux of differentiated cells. These tissues are maintained by a population of stem cells, which generate differentiated progenies and self-renew. Asymmetric division of each stem cell into one stem cell and one differentiated cell can accomplish both ...
arxiv +1 more source
A Role of the Choroid Plexus in Transplantation Therapy
Cell Transplantation, 2005 The choroid plexuses (CPs) play pivotal roles in the most basic aspects of neural function. Some of the roles of the CP include maintaining the extracellular milieu of the brain by actively modulating chemical exchange between the CSF and brain ...
Dwaine F. Emerich +3 more
doaj +1 more source
Retinal Pigment Epithelial Cell Line with Fast Differentiation and Improved Barrier Properties
Pharmaceutics, 2019 Retinal pigment epithelium (RPE) acts as an outer blood−retinal barrier that limits the access of circulating xenobiotics to the eye. In addition, the RPE limits posterior elimination of intravitreally injected drugs to circulation.
Laura Hellinen +4 more
doaj +1 more source
, 2023 Our scientists have years of experience at performing gene editing with CRISPR/Cas9, from designing gRNA to transfection and single clone generation. Creative Biogene is offering a series of knockout cell lines developed by CRISPR/Cas9 system. These cell lines provide you with a convenient means to study gene functions.
openaire +2 more sources
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Cancer Reports, 2023 Background Preclinical models like cancer cell lines and patient‐derived xenografts (PDXs) are vital for studying disease mechanisms and evaluating treatment options.
Avery S. Williams +3 more
doaj +1 more source