Results 61 to 70 of about 5,658,856 (358)

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Establishment and characterization of mouse metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma organoids

Scientific Reports
Metabolic dysfunction-associated steatohepatitis (MASH) is a form of chronic liver inflammation associated with metabolic syndrome, such as obesity and a major cause of hepatocellular carcinoma (HCC).
Sumin Kim, Nahyun Jeong, Jeayeon Park, Hyojin Noh, Ja Oh Lee, Su Jong Yu, Ja-Lok Ku   +6 more
doaj   +1 more source

Mir-129-2-3p Has Tumor Suppressor Role in Ewing Sarcoma Cell Lines and Cancer Tissue Samples

Brazilian Archives of Biology and Technology, 2021
Deregulation of miRNA expressions was identified as a novel feature of tumor biology in Ewing sarcoma (EWS). The aim was to evaluate the regulatory role of miR-129-2-3p in EWS cell lines and human EWS tissue samples.
Esra Guzel Tanoglu, Yavuz Arıkan, Yavuz Selim Kabukcuoglu, Fevziye Kabukcuoglu, Alpaslan Tanoglu, Sukru Ozturk   +5 more
doaj   +1 more source

Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis [PDF]

, 2016
Human papillomavirus induced (HPV+) cancer incidence is rapidly rising, comprising 60–80% of oropharyngeal squamous cell carcinomas (OPSCCs); while rare, recurrent/metastatic disease accounts for nearly all related deaths.
Coppock, Joseph D, Lee, John H, Lee, Kimberly M, Onken, Michael D, Spanos, William C, Uppaluri, Ravindra, Vermeer, Daniel W, Vermeer, Paola D, Zeng, Erliang   +8 more
core   +2 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Effects of simulated microgravity on colorectal cancer organoids growth and drug response

Scientific Reports
Cellular and molecular dynamics of human cells are constantly affected by gravity. Alteration of the gravitational force disturbs the cellular equilibrium, which might modify physiological and molecular characteristics. Nevertheless, biological responses
Soon-Chan Kim, Min Jung Kim, Ji Won Park, Young-Kyoung Shin, Seung-Yong Jeong, Sungwan Kim, Ja-Lok Ku   +6 more
doaj   +1 more source

ManNAc attenuates Man5 glycoform abundance through GNE-mediated metabolic channeling of UDP-GlcNAc to N-glycosylation modifications via CMP-Neu5Ac biosynthesis

mAbs
N-glycosylation, a critical quality attribute of monoclonal antibodies, plays a pivotal role in regulating pharmacokinetics and pharmacodynamics through high-mannose (Man5) glycoform modulation.
Ruiqiang Sun, Miaomiao Chai, Jiahao Man, Guiju Yang, Hai Shu, Qiancheng Wang, Cong Tian, Linlin Wang, Shanhui Liao, Yifeng Zhang, Yanyan Cao, Lisha Xia, Haili Yang, Ting Zhang, Luoyan Ma, Shenwang Cao, Qiao Gao, Yichen Le, Mingli Shi, Quanxue Li, Yinmao Fan, Hang Zhou   +21 more
doaj   +1 more source

Establishment of stable expression of firefly luciferase and EGFP in a canine inflammatory mammary carcinoma cell line and tumor-bearing model in nude mice

Frontiers in Veterinary Science, 2022
Canine inflammatory mammary carcinoma (CIMC) is a type of canine malignant mammary tumor with a poor prognosis and high mortality. We transduced firefly luciferase and enhanced green fluorescent protein (EGFP) into CHMp, a CIMC cell line, and established
Fangying Zhao, Xinqiu Li, Jiayue Liu, Di Zhang, Hongxiu Diao, Degui Lin   +5 more
doaj   +1 more source

Design of Dual-band Branch-Line Coupler Based on Shunt Open-Circuit DCRLH Cells [PDF]

, 2013
In this article, the shunt open-circuit dual composite right/left-handed (DCRLH) cell is initially proposed and one dual-band branch-line coupler based on the proposed cells is designed.
Bo Tian, Guang-Ming Wang, Ke Lu
core  

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source