Results 81 to 90 of about 5,448,677 (358)
Insects, 2022 Triatomine bugs of the genera Triatoma and Rhodnius are vectors of Chagas disease, a neglected tropical disease of humans in South America caused by Trypanosoma cruzi. Triatoma virus (TrV), a natural pathogen of Triatoma infestans, has been proposed as a
Rebekah Penrice-Randal +6 more
doaj +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Viruses, 2023 RNA viruses are often cited as a significant factor affecting the populations of both domestic honey bees and wild pollinators. To expedite the development of effective countermeasures against these viruses, a more comprehensive understanding of virus ...
Dandan Yue +6 more
doaj +1 more source
Double Choco is NP-complete [PDF]
arXiv, 2022 In the Nikoli pencil-and-paper game Double Choco, a puzzle consists of an m $\times$ n grid of cells of white or gray color, separated by dotted lines where each cell possibly contains an integer. The goal is to partition the grid into blocks by drawing solid lines over the dotted lines, where every block must contain a pair of areas of white and gray ...
arxiv
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Cells, 2023 The present study aimed to establish novel canine osteosarcoma cell lines (COS3600, COS3600B, COS4074) and characterize the recently described COS4288 cells. The established D-17 cell line served as a reference.
Natascha Leitner +5 more
doaj +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands. [PDF]
, 2013 The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of structurally diverse chemicals.
Bonati, Laura +10 more
core +3 more sources
Quantitative ultrasound characterization and comparison of healthy and malignant prostate cells [PDF]
arXiv, 2019 Speed of sound and attenuation as a function of frequency between 2 and 18 MHz were measured and compared for a cancerous prostate cell line and a healthy prostate cell line. Speed of sound for the cancerous cells line was found to be 1521.4 $\pm$ 0.8~m/s, which was equivalent to the speed of sound for the healthy cell line of 1521.5 $\pm$ 0.6~m/s. The
arxiv
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source