Results 281 to 290 of about 11,198,861 (420)

Nanoneedle‐Based Electroporation for Efficient Manufacturing of Human Primary Chimeric Antigen Receptor Regulatory T‐Cells

Advanced Science, EarlyView.
Low reproducibility and inefficient gene transfer hamper clinical manufacturing of chimeric antigen receptor regulatory T cells (CAR Tregs). Nanoneedle mediated electroporation generates primary human CAR Tregs under good manufacturing practice conditions with superior efficiency compared to viral transduction.
Ningjia Sun, Cong Wang, William Edwards, Yikai Wang, Xiangrong L. Lu, Chenlei Gu, Samuel McLennan, Panicos Shangaris, Peng Qi, Daniela Mastronicola, Cristiano Scottà, Giovanna Lombardi, Ciro Chiappini   +12 more
wiley   +1 more source

Ependymal cell lineage reprogramming as a potential therapeutic intervention for hydrocephalus. [PDF]

EMBO Mol Med
Kaplani K, Lalioti ME, Vassalou S, Lokka G, Parlapani E, Kritikos G, Lygerou Z, Taraviras S.   +7 more
europepmc   +1 more source

Heterogeneity in the properties of burst-forming units of erythroid lineage in sickle cell anemia: DNA synthesis and burst-promoting activity production is related to peripheral hemoglobin F levels [PDF]

, 1990
H Croizat, HH Billett, RL Nagel
openalex   +1 more source

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics

Cell, 2019
Leif S. Ludwig, C. Lareau, J. Ulirsch, Elena Christian, C. Muus, Lauren H. Li, K. Pelka, William Ge, Yaara Oren, Alison Brack, Travis Law, Christopher Rodman, Jonathan H. Chen, G. Boland, N. Hacohen, O. Rozenblatt-Rosen, Martin J. Aryee, Jason D. Buenrostro, A. Regev, V. Sankaran   +19 more
semanticscholar   +1 more source

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

Advanced Science, EarlyView.
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie, Shang‐Hui Ye, Yu‐Ting Yue, Bao‐Hong Shi, Jing‐Ping Xu, Lian‐Jie Li, Zheng‐Biao Zou, Matthew B. Greenblatt, Na Li, Xian‐Wen Yang, Ren Xu   +10 more
wiley   +1 more source

Steroidogenic differentiation of human amniotic membrane-derived mesenchymal stem cells into a progesterone-/androgen-producing cell lineage by SF-1 and an estrogen-producing cell lineage by WT1-KTS. [PDF]

Front Endocrinol (Lausanne)
Miyazaki Y, Orisaka M, Fujita Y, Mizutani T, Yazawa T, Yoshida Y.   +5 more
europepmc   +1 more source

Characterization of mixed chimerism in patients with chronic myeloid leukemia transplanted with T-cell-depleted bone marrow: involvement of different hematologic lineages before and after relapse [PDF]

, 1993
Étienne Roux, K Abdi, Daniel E. Speiser, Claudine Helg, B Chapuis, M Jeannet, Eddy Roosnek   +6 more
openalex   +1 more source

Glycolysis‐Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Glycolysis‐derived lactate activates nucleus pulposus cell ferroptosis via Histon H3K18la‐mediated ACSL4 transcription and ACSL4 lactylation and aggravate intervertebral disc degeneration. Inhibiting glycolysis via gene silencing or chemical intervention reduces the production of lactate and ameliorates ferroptosis activation and nucleus pulposus ...
Kaiqiang Sun, Yangyang Shi, Chen Yan, Shunmin Wang, Linhui Han, Fudong Li, Ximing Xu, Yuan Wang, Jingchuan Sun, Zijian Kang, Jiangang Shi   +10 more
wiley   +1 more source

Automated cell lineage reconstruction using label-free 4D microscopy. [PDF]

Genetics
Waliman M, Johnson RL, Natesan G, Peinado NA, Tan S, Santella A, Hong RL, Shah PK.   +7 more
europepmc   +1 more source

Expression of interleukin-4 receptors on early human B-lineage cells [PDF]

, 1991
CL Law, RJ Armitage, JG Villablanca, Tucker W. LeBien   +3 more
openalex   +1 more source