Results 151 to 160 of about 14,513,312 (335)
Journal of Cell Biology, 2018 The nucleus has long been postulated to play a critical physical role during cell polarization and migration, but that role has not been defined or rigorously tested.
David M Graham +9 more
semanticscholar +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Fluid shear stress induces cell migration and invasion via activating autophagy in HepG2 cells
Cell Adhesion & Migration, 2019 Fluid shear stress (FSS) regulates the metastasis of hepatocellular carcinoma (HCC). In the present study, we aimed to study the role of autophagy in HCC cells under FSS.
Zhiping Yan +6 more
doaj +1 more source
A stochastic model for protrusion activity
, 2018 In this work we approach cell migration under a large-scale assumption, so that the system reduces to a particle in motion. Unlike classical particle models, the cell displacement results from its internal activity: the cell velocity is a function of the
Etchegaray, Christèle, Meunier, Nicolas
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
A congestion model for cell migration
, 2011 This paper deals with a class of macroscopic models for cell migration in a saturated medium for two-species mixtures. Those species tend to achieve some motion according to a desired velocity, and congestion forces them to adapt their velocity.
Dambrine, Julien +3 more
core +3 more sources
Regulation of ATP utilization during metastatic cell migration by collagen architecture
Molecular Biology of the Cell, 2018 Cells expend energy to migrate. Metastatic cancer cell energy levels were investigated as a function of collagen architecture. In more migration-permissive environments or when migration is pharmacologically inhibited, cells reduce ATP:ADP levels ...
Matthew R. Zanotelli +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Cell Adhesion & MigrationThe potential of adult adipose-derived stromal cells (ADSCs) to differentiate into astrocytes holds promise for future cell transplantation therapies.
Pingshu Zhang +5 more
doaj +1 more source