Results 91 to 100 of about 1,369,656 (306)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Thermodynamic pathways to genome spatial organization in the cell nucleus [PDF]

, 2009
The architecture of the eukaryotic genome is characterized by a high degree of spatial organization. Chromosomes occupy preferred territories correlated to their state of activity and, yet, displace their genes to interact with remote sites in complex ...
Akhtar, Antonella Prisco, Bantignies, Berg, Binder, Binder, Bohn, Bon, Branco, Brown, Chuang, Cook, Cremer, de Laat, de Laat, Doi, Donohoe, Drissen, Fraser, Galande, Gerland, Hahnfeldt, Hancock, Hancock, Handwerger, Hediger, Jing, Kreth, Kurukuti, Kwon, Lanctôt, Lassig, Ling, Locke, Lomvardas, Maerkl, Marenduzzo, Marenduzzo, Mario Nicodemi, Massie, Maynard, Meaburn, Mergell, Misteli, Misteli, Morozov, Munkel, Munkel, Nicodemi, Nicodemi, Nicodemi, Nicodemi, Osborne, Osborne, Purbey, Sachs, Scialdone, Simonis, Spilianakis, Stanley, Takizawa, Vakoc, Xu, Yokota, Zhao   +64 more
core   +3 more sources

Actomyosin contractility rotates the cell nucleus [PDF]

, 2013
The nucleus of the eukaryotic cell functions amidst active cytoskeletal filaments, but its response to the stresses carried by these filaments is largely unexplored. We report here the results of studies of the translational and rotational dynamics of the nuclei of single fibroblast cells, with the effects of cell migration suppressed by plating onto ...
arxiv   +1 more source

Inferring geometrical dynamics of cell nucleus translocation [PDF]

arXiv, 2023
The ability of eukaryotic cells to squeeze through constrictions is limited by the stiffness of their large and rigid nucleus. However, migrating cells are often able to overcome this limitation and pass through constrictions much smaller than their nucleus, a mechanism that is not yet understood.
arxiv  

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Phosphorylation of nuclear Tau is modulated by distinct cellular pathways [PDF]

, 2018
Post-translational protein modification controls the function of Tau as a scaffold protein linking a variety of molecular partners. This is most studied in the context of microtubules, where Tau regulates their stability as well as the distribution of ...
Boersema, Paul, Cal\uec, Tito, Foglieni, Chiara, Paganetti, Paolo, Papin, St\ue9phanie, Picotti, Paola, Salvad\ue8, Agnese, Sola, Martina, Ulrich, Giorgio   +8 more
core   +2 more sources

Cell Injection Millirobot Development and Evaluation in Microfluidic Chip

Micromachines, 2018
We propose an innovative design of millirobot, which can achieve donor cell suction, delivery, and injection in a mammalian oocyte on a microfluidic chip.
Lin Feng, Qiang Zhou, Bin Song, Yanmin Feng, Jun Cai, Yonggang Jiang, Deyuan Zhang   +6 more
doaj   +1 more source

Numerical Model for the Deformation of Nucleated Cells by Optical Stretchers [PDF]

arXiv, 2015
In this paper, we seek to model the deformation of nucleated cells by single diode-laser bar optical stretchers. We employ a recently developed computational model, the Dynamic Ray-Tracing method, to determine the stress distribution induced by the applied optical forces on a capsule encapsulating a nucleus of different optical properties. These forces
arxiv  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Negative Correlation between the Diffusion Coefficient and Transcriptional Activity of the Glucocorticoid Receptor [PDF]

, 2017
The glucocorticoid receptor (GR) is a transcription factor, which interacts with DNA and other cofactors to regulate gene transcription. Binding to other partners in the cell nucleus alters the diffusion properties of GR.
Horio, Takashi, Kinjo, Masataka, Mikuni, Shintaro, Yamamoto, Johtaro   +3 more
core   +1 more source