Results 91 to 100 of about 1,337,831 (333)

The effect of nucleus size on the cell dose in targeted radionuclide therapy – A monte carlo study

Journal of Medical Signals and Sensors, 2020
Background: Nowadays, the use of radiopharmaceuticals in medicine is unavoidable. Depending on the distribution of the radiopharmaceutical in the cells, the nucleus absorbed dose changes by the variations in their geometry size.
Ebrahim Kouhkan, Nahid Chegeni, Amjad Hussain   +2 more
doaj   +1 more source

Differences in the localization and morphology of chromosomes in the human nucleus [PDF]

, 1999
Using fluorescence in situ hybridization we show striking differences in nuclear position, chromosome morphology, and interactions with nuclear substructure for human chromosomes 18 and 19.
Andrulis, Bickmore, Bickmore, Bregman, Bridger, Bridger, Brown, Carmo-Fonseca, Carter, Craig, Craig, Cremer, Cross, Csink, Csink, Deloukas, Dernburg, Dutrillaux, Eils, Ferguson, Ferreira, Fox, Funabiki, Gerace, Gerdes, Gotta, Guan, Haaf, Haaf, Hiraoka, Jackson, Jeppesen, Kaplan, Kill, Korenberg, Kurz, Leitch, Li, Luderus, Manuelidis, Marshall, Marshall, Mirkovitch, Morton, Nagele, Qumsiyeh, Rae, Scheer, Van Dyke, Visser, Vourc'h, Xing, Yokota   +52 more
core   +5 more sources

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Thermal instability of cell nuclei

New Journal of Physics, 2014
DNA is known to be a mechanically and thermally stable structure. In its double stranded form it is densely packed within the cell nucleus and is thermo-resistant up to $70\:^\circ {\rm{C}}$ .
Enrico Warmt, Tobias R Kießling, Roland Stange, Anatol W Fritsch, Mareike Zink, Josef A Käs   +5 more
doaj   +1 more source

Rabl's model of the interphase chromosome arrangement tested in Chinise hamster cells by premature chromosome condensation and laser-UV-microbeam experiments [PDF]

, 1982
In 1885 Carl Rabl published his theory on the internal structure of the interphase nucleus. We have tested two predictions of this theory in fibroblasts grown in vitro from a female Chinese hamster, namely (1) the Rabl-orientation of interphase ...
C Cremer, C Cremer, C Cremer, C Cremer, C Cremer, C Rabl, C Zorn, C Zorn, C. Cremer, C. Zorn, DE Comings, DE Comings, DM Pardoll, E. K. Luedtke, F Vogel, H Hoehn, H Zankl, H. Baumann, K Sperling, K Sperling, K Sperling, K. Sperling, KD Zang, L Avivi, L Hens, M Kirsch-Volders, M Kirsch-Volders, R Berezney, T Cremer, T. Cremer, Th Boveri, Th Boveri, V. Teuber, W Schnedl, Y Moroi   +34 more
core   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Dual-color dSTORM imaging and ThunderSTORM image reconstruction and analysis to study the spatial organization of the nuclear phosphatidylinositol phosphates

MethodsX, 2021
Single molecule localization microscopy (SMLM) provided an unprecedented insight into the sub-nuclear organization of proteins and nucleic acids but apart from the nuclear envelope the role of the nuclear lipids in the functional organization of the cell
Peter Hoboth, Ondřej Šebesta, Martin Sztacho, Enrique Castano, Pavel Hozák   +4 more
doaj  

Pressure-driven release of viral genome into a host nucleus is a mechanism leading to herpes infection

eLife, 2019
Many viruses previously have been shown to have pressurized genomes inside their viral protein shell, termed the capsid. This pressure results from the tight confinement of negatively charged viral nucleic acids inside the capsid.
Alberto Brandariz-Nuñez, Ting Liu, Te Du, Alex Evilevitch   +3 more
doaj   +1 more source

Unscheduled DNA synthesis after partial UV irradiation of the cell nucleus [PDF]

, 1979
Cells of an euploid strain of the Chinese hamster synchronized in the G1 phase were microirradiated in the nucleus with a laser UV microbeam (λ = 257 nm) and pulse-labelled with [3H]thymidine. In autoradiographs of cells fixed immediately after the pulse
Berliner, Bostock, Brown, Christian Zorn, Christoph Cremer, Cleaver, Cohen, Comings, Cremer, Cremer, Cremer, Cremer, Deaven, Diaz, Dutrillaux, Ehmann, Feldman, Ghosh, Godin, Harris, Heneen, Hens, Hobarth, Hsu, Johnson, Juricek, Jürgen Zimmer, Loza Bonifaz, Moreno, Moreno, Nichols, Rasmussen, Robards, Sakharov, Sakharov, Schempp, Schwarzacher, Singh, Thomas Cremer, Vogel, Warburton, Werry, Wilkins, Williams, Yatani, Zorn, Zorn, Zorn   +47 more
core   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source