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Cell nucleus as endogenous biological micropump
Biosensors and Bioelectronics, 2021Micropumps can generate directional microflows in blood vessels or bio-capillaries for targeted transport of nanoparticles and cells in vivo, which is highly significant for biomedical applications from active drug delivery to precision clinical therapy.
Qing Gao +8 more
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2018
Nucleus is a specialized organelle that serves as a control tower of all the cell behavior. While traditional biochemical features of nuclear signaling have been unveiled, many of the physical aspects of nuclear system are still under question. Innovative biophysical studies have recently identified mechano-regulation pathways that turn out to be ...
Dong-Hwee, Kim +2 more
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Nucleus is a specialized organelle that serves as a control tower of all the cell behavior. While traditional biochemical features of nuclear signaling have been unveiled, many of the physical aspects of nuclear system are still under question. Innovative biophysical studies have recently identified mechano-regulation pathways that turn out to be ...
Dong-Hwee, Kim +2 more
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Nucleus and nucleus-cytoskeleton connections in 3D cell migration
Experimental Cell Research, 2016Cell migration plays an important role in many physiological and pathological settings, ranging from embryonic development to cancer metastasis. Currently, accumulating data suggest that cells migrating in three-dimensional (3D) environments show well-defined differences compared to their well-established two-dimensional (2D) counterparts.
Lingling, Liu +3 more
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Editorial overview: Cell nucleus: The nucleus: a dynamic organelle
Current Opinion in Cell Biology, 2014The nucleus is perhaps the defining feature of ‘eukaryotes’ (Greek ‘eu-’ (with) ‘-karyon’ (kernel, nucleus)), and the emperor of all eukaryotic organelles in terms of scale and complexity of organization. It is, of course, the repository for almost all genomic information, encoded in DNA sequences wrapped into chromatin as discrete polymer packages ...
Michael P, Rout, Gary H, Karpen
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Guanine Quadruplexes in Cell Nucleus Metabolism
Molecular Biology, 2021Cell metabolism depends, to a large extent, on correct regulation of gene expression. One of the mechanisms of regulation is the formation of nucleic acid secondary structures, among which guanine quadruplexes (G-quadruplexes, or G4) are of particular importance.
E V, Marilovtseva, V M, Studitsky
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BioEssays, 1988
AbstractThe origin of mitosis and the nuclear envelope were the pivotal processes in the evolutionary origin of the nucleus; they probably occurred in a wall‐less mutant bacterium that evolved a cytoskeleton and phagocytosis about 1500 million years ago.
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AbstractThe origin of mitosis and the nuclear envelope were the pivotal processes in the evolutionary origin of the nucleus; they probably occurred in a wall‐less mutant bacterium that evolved a cytoskeleton and phagocytosis about 1500 million years ago.
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Indian Journal of Cancer, 2015
To investigate the feasibility of inducing adipose-derived stem cells (ADSCs) to nucleus pulposus cells (NPCs).ADSCs were isolated from rabbit while NPCs were isolated from an allogeneic rabbit. NPCs were co-cultured with the 3rd generation ADSCs in co-cultured system. Only NPCs were cultured in single culturing group.
J, Xu, D L, Qi, X J, Pang, C W, Jing
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To investigate the feasibility of inducing adipose-derived stem cells (ADSCs) to nucleus pulposus cells (NPCs).ADSCs were isolated from rabbit while NPCs were isolated from an allogeneic rabbit. NPCs were co-cultured with the 3rd generation ADSCs in co-cultured system. Only NPCs were cultured in single culturing group.
J, Xu, D L, Qi, X J, Pang, C W, Jing
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Protein Synthesis in the Cell Nucleus
Nature, 1955THERE is considerable evidence that the cytoplasm of the cell contains structures capable of carrying out protein synthesis1, and it has been shown in one case2 that formation of protein may be little affected by removal of the nucleus. These findings seem to exclude the appealing hypothesis that the nucleus is the source of the cell's proteins.
D, MAZIA, D M, PRESCOTT
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Macromolecular Domains within the Cell Nucleus
Annual Review of Cell Biology, 1993DNA REPLICATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 276 TRANSCRIPTION AND PRE-mRNA PROCESSING .... . . ) ....... ,.... 279 Localization of Transcriptionally Active Nuclear Regions by [ HJ-Uridine Incorporation or In Situ Nick Translation . . . . . . . . . . . . . . . . 279 Pre-mRNA Splicing . . . . . . . . . . .
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Cell Biology of the Plant Nucleus
Annual Review of Plant Biology, 2017The eukaryotic nucleus is enclosed by the nuclear envelope, which is perforated by the nuclear pores, the gateways of macromolecular exchange between the nucleoplasm and cytoplasm. The nucleoplasm is organized in a complex three-dimensional fashion that changes over time and in response to stimuli.
Iris, Meier +2 more
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