Results 11 to 20 of about 20,297,709 (266)

Neonatal corticosterone administration increases p27-positive Sertoli cell number and decreases Sertoli cell number in the testes of mice at prepuberty [PDF]

Scientific Reports, 2022
Cortisol and corticosterone (CORT) are steroid, antistress hormones and one of the glucocorticoids in humans and animals, respectively. This study evaluated the effects of CORT administration on the male reproductive system in early life stages. CORT was
Hidenobu Miyaso, Kaiya Takano, Kenta Nagahori, Zhong-Lian Li, Shinichi Kawata, Miyuki Kuramasu, Yuki Ogawa, Hirotaka Yoshioka, Yoshiharu Matsuno, Satoshi Yokota, Masahiro Itoh   +10 more
doaj   +2 more sources

ComProliM: A cell growth assay robust to initial cell number in co-culture system [PDF]

Heliyon, 2023
Cell growth is conventionally quantified using CCK-8 or MTT assays, but these methods display considerable sensitivity to initial cell quantities.
Yunda Song, MD, Subo Zhang, MD
doaj   +2 more sources

Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma [PDF]

, 2021
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the mechanism underpinning therapeutic response.
Schnidrig, D, Sunderland, MW, Ghorani, E, Lingard, K, Rowan, A, Jamal-Hanjani, M, Litchfield, K, Turajlic, S, Becker, PD, Swanton, C, Borg, E, PEACE Consortium, Hatipoglu, E, Mahadeva, U, Xu, H, Hazell, S, Mitchison, M, Green, A, TRACERx Renal Consortium, Reading, JL, Sarker, S, Robert de Massy, M, Nicol, D, TRACERx Renal Consortium,, Falzon, M, López, JI, Edmonds, K, Carlyle, E, Mason, R, Salgado, R, Vasquez, MD, Uddin, I, Au, L, Proctor, I, Yang, WW, Quezada, SA, Spencer, C, Fotiadis, N, Shepherd, STC, Mangwende, M, Dhillon, K, Joshi, K, Lund, T, Byrne, F, Horswell, S, Beattie, G, Moore, DA, PEACE Consortium,, Furness, AJS, Puccio, I, Akarca, A, Thompson, R, Larkin, J, Chain, B, Del Rosario, L, Fendler, A, Pickering, L, Kassiotis, G, Marafioti, T, Attig, J   +59 more
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Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition [PDF]

, 2021
Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumor-cell-intrinsic and microenvironmental features underpinning CPI sensitization.
Turati, Virginia, Rosenthal, R, Saini, SK, Rosenthal, Rachel, Herrero, Javier, Rowan, A, Turajlic, Samra, Litchfield, K, Guerra-Assunção, José Afonso, Turajlic, S, Hellmann, Matthew D., Swanton, C, Saini, Sunil Kumar, Larkin, James, McGranahan, Nicholas, Reading, JL, Puttick, C, Reading, James L., Swanton, Charles, Thakkar, K, Al Bakir, M, Conde, L, Lim, Emilia, Watkins, TBK, Biswas, D, Enver, Tariq, Puttick, Clare, Turati, V, Litchfield, Kevin, Watkins, Thomas B.K., Hellmann, MD, Rowan, Andrew, Lim, E, Biswas, Dhruva, Van Loo, P, Quezada, SA, Guerra-Assunção, JA, Quezada, Sergio A., Bentham, Robert, Herrero, J, Enver, T, Furness, Andrew J.S., Hadrup, Sine R., Conde, Lucia, Hadrup, SR, Abbosh, C, Lee, Se Hoon, Furness, AJS, Lee, S-H, Al Bakir, Maise, Abbosh, Chris, McGranahan, N, Bentham, R, Larkin, J, Van Loo, Peter, Thakkar, Krupa, James L. Reading, Sunil Kumar Saini, Samra Turajlic, Maise Al Bakir, Nicholas McGranahan, Rachel Rosenthal, Kevin Litchfield, Matthew D. Hellmann, José Afonso Guerra-Assunção, Charles Swanton, Dhruva Biswas, Tariq Enver, Andrew Rowan, Sergio A. Quezada, Lucia Conde, Andrew J.S. Furness, Krupa Thakkar, Virginia Turati, Se-Hoon Lee, James Larkin, Javier Herrero, Robert Bentham, Peter Van Loo, Clare Puttick, Emilia Lim, Chris Abbosh, Sine R. Hadrup, Thomas B.K. Watkins   +83 more
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De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis [PDF]

, 2018
We previously established the contribution of de novo damaging sequence variants to Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence an additional 291 TD trios and analyze the combined set of 802 trios.
천근아, 김은주, 송동호
core   +3 more sources

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.

, 2022
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma.
Raine, K, Yates, LR, Teague, J, Lopez, JI, Gore, M, Rowan, A, Mitchell, TJ, Lynch, AG, Au, L, Stewart, A, Litchfield, K, Turajlic, S, Tarpey, P, Chandra, A, Csabai, I, Swanton, C, Fotiadis, N, Lynch, J, Soultati, A, Challacombe, B, Xu, H, Hazell, S, Stamp, G, Elaidi, R, Horswell, S, Campbell, PJ, Chowdhury, S, Butler, AP, Rudman, S, Wedge, DC, Futreal, PA, Nicol, D, Farmery, JHR, O'Brien, T, Maura, F, McGranahan, N, TRACERx Renal Consortium,, Spain, L, Stewart, GD, Szallasi, Z, Martincorena, I, Stares, M, Fernando, A, Larkin, J, Oudard, S, Pickering, L, Chambers, T, Angelopoulos, N   +47 more
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Representation of uncertain multichannel digital signal spaces and study of pattern recognition based on metrics and difference values on fuzzy n-cell number spaces [PDF]

, 2009
In this paper, we discuss the problem of characterization for uncertain multichannel digital signal spaces, propose using fuzzy n-cell number space to represent uncertain n-channel digital signal space, and put forward a method of constructing such fuzzy
Shi, Peng, Wang, Guixiang, Messenger, P., Wang, G., Messenger, Paul, Shi, P., P. Messenger, null Guixiang Wang, null Peng Shi   +8 more
core   +2 more sources

SDF1 Gene Variation Is Associated with Circulating SDF1 alpha Level and Endothelial Progenitor Cell Number-The Bruneck Study [PDF]

, 2008
BACKGROUND: Stromal cell-derived factor-1 (SDF1) and its receptor CXC chemokine receptor 4 (CXCR4) play a critical role in progenitor cell homing, mobilization and differentiation.
Marjan Jahangiri, Kiechl, Stefan, Mayr, A, Willeit, J, Qingzhong Xiao, Friedrich Oberhollenzer, Xu Qingbo, Jahangiri, M, Ye Shu, Oberhollenzer Friedrich, Jahangiri, Marjan, Willeit Johann, Mayr, Agnes, Oberhollenzer, F, Mayr Agnes, Willeit, Johann, Ye, Shu, Xiao, Q, Ye, S, Kiechl, S, Kiechl Stefan, Xu, Q, Jahangiri Marjan, Stefan Kiechl, Qingbo Xu, Xiao Qingzhong, Johann Willeit, Oberhollenzer, Friedrich, Xu, Qingbo, Shu Ye, Agnes Mayr, Xiao, Qingzhong   +31 more
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Regulation of hair cell and stomatal size by a hair cell-specific peroxidase in the grass Brachypodium distachyon. [PDF]

, 2023
The leaf epidermis is the outermost cell layer forming the interface between plants and the atmosphere that must both provide a robust barrier against (a)biotic stressors and facilitate carbon dioxide uptake and leaf transpiration.1 To achieve these ...
Berg, Lea S, Lindner, Heike, Michael T. Raissig, Tiago D.G. Nunes, Raissig, Michael T, Slawinska, Magdalena, Nunes, Tiago D G, Raissig, Michael, Jesenofsky, Barbara, Richard Sibout, Sibout, Richard, Vogel, John P, Leonie Redt, Vogel, John, Heike Lindner, John P. Vogel, Berg, Lea, Lea S. Berg, Nunes, Tiago D.G., Barbara Jesenofsky, Laudencia-Chingcuanco, Debbie, Redt, Leonie, Slawinska, Magdalena W, Zhang, Dan, Debbie Laudencia-Chingcuanco, Dan Zhang, Magdalena W. Slawinska   +26 more
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Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen [PDF]

, 2008
Spermatogenesis in the adult male depends on the action of FSH and androgen. Ablation of either hormone has deleterious effects on Sertoli cell function and the progression of germ cells through spermatogenesis.
Baker, P.J., Guillou, F., Abel, M.H., Verhoeven, G., De Gendt, K., Guillou, Florian Jean Louis, Charlton, H.M., Monteiro, A., O'Shaughnessy, P.J.   +8 more
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