Results 241 to 250 of about 5,360,136 (290)

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Synthesis and Investigation of Peptide-Drug Conjugates Comprising Camptothecin and a Human Protein-Derived Cell-Penetrating Peptide. [PDF]

Chem Biol Drug Des
Palombi IR, White AM, Koda Y, Craik DJ, Lawrence N, Malins LR.   +5 more
europepmc   +1 more source

A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Advanced Science, EarlyView.
A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao, Yufei Lan, Min‐Goo Lee, Jinjun He, Yueran Pan, Eunji Kim, Xin Fu, Sungwook Jung, Wanxia Lu, Jinyue Fan, Haoxiang Chen, Yuanbo Zhao, Yuling Xu, Jong Seung Kim, Chao Zhang   +14 more
wiley   +1 more source

Designed Cell-Penetrating Peptide Constructs for Inhibition of Pathogenic Protein Self-Assembly. [PDF]

Pharmaceutics
Kalmouni M, Oh Y, Alata W, Magzoub M.
europepmc   +1 more source

Cell-Penetrating Peptide Enhances Tafazzin Gene Therapy in Mouse Model of Barth Syndrome. [PDF]

Int J Mol Sci
Raghav R, Awata J, Martin GL, Strathdee D, Blanton RM, Chin MT.   +5 more
europepmc   +1 more source

Coassembly of Cell-Penetrating Peptide Octaarginine with Acetazolamide: Emergent Interactions with E. coli. [PDF]

ACS Omega
Choubey R, Chatterjee M, Pandey PK, Mishra A, Datta B.   +4 more
europepmc   +1 more source

Targeting <i>carA</i> Using Optimized Antisense Peptide Nucleic Acid-Cell-Penetrating Peptide Conjugates in <i>Acinetobacter baumannii</i>: A Novel Antibacterial Approach. [PDF]

Int J Mol Sci
Seo JH, Kim YJ, Jeon WJ, Yoo JS, Moon DC.   +4 more
europepmc   +1 more source

Cell-penetrating peptide-grafted AAV2 capsids for improved retinal delivery via intravitreal injection. [PDF]

Mol Ther Methods Clin Dev
Wang JH, Cui M, Liu H, Guo P, McGowan J, Cheng SY, Gessler DJ, Xie J, Punzo C, Tai PWL, Gao G.   +10 more
europepmc   +1 more source

Cell-Penetrating Peptides

, 2021
In this introductory chapter, we first define cell-penetrating peptides (CPPs), give short overview of CPP history and discuss several aspects of CPP classification. Next section is devoted to the mechanism of CPP penetration into the cells, where direct and endocytic internalization of CPP is explained.
Matjaž, Zorko, Ülo, Langel
openaire   +3 more sources