Results 71 to 80 of about 124,652 (274)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Computational insights in cell physiology
Frontiers in Systems BiologyPhysiological processes are governed by intricate networks of transcriptional and post-translational regulations. Inter-cellular interactions and signaling pathways further modulate the response of the cells to environmental conditions. Understanding the
Geneviève Dupont, Didier Gonze
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2015 Models for genetic regulation and cell fate specification characteristically assume that gene regulatory networks (GRNs) are essentially deterministic and exhibit multiple stable states specifying alternate, but pre-figured cell fates. Mounting evidence
Karl J. Niklas +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Mitochondrial respiration and Ca2+ waves are linked during fertilization and meiosis completion [PDF]
, 2003 Fertilization increases both cytosolic Ca(2+) concentration and oxygen consumption in the egg but the relationship between these two phenomena remains largely obscure.
Smith, Peter J. +9 more
core +1 more source
PhagoKinetic Track Assay: Imaging and Analysis of Single Cell Migration
Bio-Protocol, 2016 Cell migration is a highly complex and dynamic biological process, essential in several physiological phenomena and pathologies including cancer dissemination and metastasis formation.
Michiel Fokkelman +5 more
doaj +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
A Temporal Signal-Processing Circuit Based on Spiking Neuron and Synaptic Learning
Frontiers in Computational Neuroscience, 2019 Time is a continuous, homogeneous, one-way, and independent signal that cannot be modified by human will. The mechanism of how the brain processes temporal information remains elusive.
Hui Wei, Yi-Fan Du
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STEMedicine, 2020 The nuclear factor κB (NF-κB) transcription factors exert central hub functions in multiple physiological processes including immune response, cell survival, proliferation and cytokine production, which has naturally become the core of research almost in
Jian-shuai Yu, Jin Jin, Yi-yuan Li
doaj +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source