Results 51 to 60 of about 124,652 (274)
Engineering Proceedings, 2023 In this work, an amperometric biosensor for lactate determination based on a sonogel–carbon transducer has been developed and evaluated using the lactate oxidase enzyme coated with a multipolymer layer as a bioreceptor.
Alfonso Sierra-Padilla +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Regulation of Ins(3,4,5,6)P-4 signaling by a reversible kinase/phosphatase
, 2019 Regulation of Cl- channel conductance by Ins(3,4,5,6)P-4 provides receptor-dependent control over salt and fluid secretion [1], cell volume homeostasis [2], and electrical excitability of neurones and smooth muscle [3]. Ignorance of how Ins(3,4,5,6)P4 is
Yang, XN +11 more
core +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Physiological and pathological cell fate reprogramming: A mathematical approach.
, 2019 Reprogramming-like phenomena in response to damage signalling may constitute a reparative route through which human tissues respond to injury, stress, and disease via induction of a transient acquisition of epigenetic plasticity and phenotypic ...
Núria Folguera-Blasco (4966204) +4 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Cells, 2021 Cholinergic innervation in the pancreas controls both the release of digestive enzymes to support the intestinal digestion and absorption, as well as insulin release to promote nutrient use in the cells of the body.
Nastja Sluga +5 more
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
THE PHYSIOLOGICAL IMPLICATIONS OF DRUG OXIDATIONS TO THE CELL
, 1977 This chapter discusses the physiological implications of drug oxidations to the cell. The conversion of various lipophilic drugs to hydrophilic and excretable products occurs predominantly in the liver as a multistep metabolic process that most often ...
Högberg, J +7 more
core +1 more source