Results 1 to 10 of about 809,287 (119)

In Vitro Veritas: From 2D Cultures to Organ-on-a-Chip Models to Study Immunogenic Cell Death in the Tumor Microenvironment

Cells, 2022
Immunogenic cell death (ICD) is a functionally unique form of cell death that promotes a T-cell-dependent anti-tumor immune response specific to antigens originating from dying cancer cells.
Dmitri V. Krysko, Robin Demuynck, Iuliia Efimova, Faye Naessens, Olga Krysko, Elena Catanzaro   +5 more
doaj   +1 more source

HS3ST2 expression induces the cell autonomous aggregation of tau

Scientific Reports, 2022
Heparan sulfates have long been known to intracellularly accumulate in Alzheimer’s disease neurons, where they colocalize with neurofibrillary tangles made of abnormally phosphorylated and aggregated tau protein.
M. B. Huynh, N. Rebergue, H. Merrick, W. Gomez-Henao, E. Jospin, D. S. F. Biard, D. Papy-Garcia   +6 more
doaj   +1 more source

Ferroptosis: friend or foe in cancer immunotherapy?

OncoImmunology, 2023
Ferroptosis has gained interest due to it immunogenicity and the higher sensitivity of cancer cells to it. However, it was recently shown that ferroptosis in tumor-associated neutrophils leads to immunosuppression and negatively impacts therapy. Here, we
Robin Demuynck, Iuliia Efimova, Elena Catanzaro, Dmitri V Krysko   +3 more
doaj   +1 more source

Sulfated Undaria pinnatifida Polysaccharide Promotes Endocytosis of Nano-Calcium Oxalate Dihydrate by Repairing Subcellular Organelles in HK-2 Cells

Antioxidants, 2023
The clinical manifestation of primary hyperoxaluria includes hyperoxaluria and recurrent urinary calculi. In this study, an oxidative damage model was constructed based on oxalate damage to the human renal proximal tubular epithelial cells (HK-2), and a ...
Xue-Wu Chen, Yu-Yun Zheng, Jian-Ming Ouyang   +2 more
doaj   +1 more source

Heparan sulfate functions are altered in the osteoarthritic cartilage

Arthritis Research & Therapy, 2020
Background Heparan sulfate (HS) proteoglycans (PG) may be found at the chondrocyte surface and in the pericellular cartilage matrix, and are involved in cell-cell and cell-matrix interactions.
Sara Shamdani, Sandrine Chantepie, Camille Flageollet, Nadia Henni-Chebra, Yohann Jouan, Florent Eymard, Eric Hay, Martine Cohen-Solal, Dulce Papy-Garcia, Xavier Chevalier, Patricia Albanese   +10 more
doaj   +1 more source

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns

Molecular Autism, 2020
Background Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder.
Shreya Das Sharma, Rakhi Pal, Bharath Kumar Reddy, Bhuvaneish T. Selvaraj, Nisha Raj, Krishna Kumar Samaga, Durga J. Srinivasan, Loren Ornelas, Dhruv Sareen, Matthew R. Livesey, Gary J. Bassell, Clive N. Svendsen, Peter C. Kind, Siddharthan Chandran, Sumantra Chattarji, David J. A. Wyllie   +15 more
doaj   +1 more source

A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo

Nature Communications, 2021
Engineering de novo synapse-like connections between neurons could enhance our understanding of neuronal circuits and how they generate behaviour. The authors present a two-component system that creates synthetic neuromodulatory connections to manipulate
Josh D. Hawk, Elias M. Wisdom, Titas Sengupta, Zane D. Kashlan, Daniel A. Colón-Ramos   +4 more
doaj   +1 more source

NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP

Molecular Brain, 2019
Protein synthesis is crucial for maintaining synaptic plasticity and synaptic signalling. Here we have attempted to understand the role of RNA binding proteins, Fragile X Mental Retardation Protein (FMRP) and Moloney Leukemia Virus 10 (MOV10) protein in ...
Preeti Madhav Kute, Sarayu Ramakrishna, Nagammal Neelagandan, Sumantra Chattarji, Ravi. S. Muddashetty   +4 more
doaj   +1 more source

A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues

Scientific Reports, 2022
Recent research on normal human tissues identified omnipresent clones of cells, driven by somatic mutations known to be responsible for carcinogenesis (e.g., in TP53 or NOTCH1). These new insights are fundamentally changing current tumor evolution models,
Tom Luijts, Kerryn Elliott, Joachim Tetteh Siaw, Joris Van de Velde, Elien Beyls, Arne Claeys, Tim Lammens, Erik Larsson, Wouter Willaert, Anne Vral, Jimmy Van den Eynden   +10 more
doaj   +1 more source

NEDD4-1 deficiency impairs satellite cell function during skeletal muscle regeneration

Biological Research, 2023
Background Satellite cells are tissue-specific stem cells primarily responsible for the regenerative capacity of skeletal muscle. Satellite cell function and maintenance are regulated by extrinsic and intrinsic mechanisms, including the ubiquitin ...
Felipe Cabezas, Claudio Cabello-Verrugio, Natalia González, Jeremy Salas, Manuel J. Ramírez, Eduardo de la Vega, Hugo C. Olguín   +6 more
doaj   +1 more source