Results 11 to 20 of about 13,519,306 (307)

Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke.

Immunity, 2021
The precise mechanisms underlying the beneficial effects of regulatory T (Treg) cells on long-term tissue repair remain elusive. Here, using single-cell RNA sequencing and flow cytometry, we found that Treg cells infiltrated the brain 1 to 5 weeks after ...
Ligen Shi, Zeyu Sun, W. Su, Fei Xu, Di Xie, Qingxiu Zhang, Xuejiao Dai, Kartik Iyer, T. K. Hitchens, L. Foley, Sicheng Li, D. Stolz, Kong Chen, Ying Ding, A. Thomson, R. Leak, Jun Chen, Xiaoming Hu   +17 more
semanticscholar   +1 more source

Sulfated Undaria pinnatifida Polysaccharide Promotes Endocytosis of Nano-Calcium Oxalate Dihydrate by Repairing Subcellular Organelles in HK-2 Cells

Antioxidants, 2023
The clinical manifestation of primary hyperoxaluria includes hyperoxaluria and recurrent urinary calculi. In this study, an oxidative damage model was constructed based on oxalate damage to the human renal proximal tubular epithelial cells (HK-2), and a ...
Xue-Wu Chen, Yu-Yun Zheng, Jian-Ming Ouyang   +2 more
doaj   +1 more source

Heparan sulfate functions are altered in the osteoarthritic cartilage

Arthritis Research & Therapy, 2020
Background Heparan sulfate (HS) proteoglycans (PG) may be found at the chondrocyte surface and in the pericellular cartilage matrix, and are involved in cell-cell and cell-matrix interactions.
Sara Shamdani, Sandrine Chantepie, Camille Flageollet, Nadia Henni-Chebra, Yohann Jouan, Florent Eymard, Eric Hay, Martine Cohen-Solal, Dulce Papy-Garcia, Xavier Chevalier, Patricia Albanese   +10 more
doaj   +1 more source

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns

Molecular Autism, 2020
Background Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder.
Shreya Das Sharma, Rakhi Pal, Bharath Kumar Reddy, Bhuvaneish T. Selvaraj, Nisha Raj, Krishna Kumar Samaga, Durga J. Srinivasan, Loren Ornelas, Dhruv Sareen, Matthew R. Livesey, Gary J. Bassell, Clive N. Svendsen, Peter C. Kind, Siddharthan Chandran, Sumantra Chattarji, David J. A. Wyllie   +15 more
doaj   +1 more source

A genetically encoded tool for reconstituting synthetic modulatory neurotransmission and reconnect neural circuits in vivo

Nature Communications, 2021
Engineering de novo synapse-like connections between neurons could enhance our understanding of neuronal circuits and how they generate behaviour. The authors present a two-component system that creates synthetic neuromodulatory connections to manipulate
Josh D. Hawk, Elias M. Wisdom, Titas Sengupta, Zane D. Kashlan, Daniel A. Colón-Ramos   +4 more
doaj   +1 more source

Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury

Cellular and Molecular Life Sciences, 2020
The great plasticity of Schwann cells (SCs), the myelinating glia of the peripheral nervous system (PNS), is a critical feature in the context of peripheral nerve regeneration following traumatic injuries and peripheral neuropathies. After a nerve damage,
Gianluigi Nocera, Claire Jacob
semanticscholar   +1 more source

Reprogramming Cells for Brain Repair [PDF]

Brain Sciences, 2013
At present there are no clinical therapies that can repair traumatic brain injury, spinal cord injury or degenerative brain disease. While redundancy and rewiring of surviving circuits can recover some lost function, the brain and spinal column lack sufficient endogenous stem cells to replace lost neurons or their supporting glia.
Randall D. McKinnon, Alyx T. Guarino
openaire   +3 more sources

NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP

Molecular Brain, 2019
Protein synthesis is crucial for maintaining synaptic plasticity and synaptic signalling. Here we have attempted to understand the role of RNA binding proteins, Fragile X Mental Retardation Protein (FMRP) and Moloney Leukemia Virus 10 (MOV10) protein in ...
Preeti Madhav Kute, Sarayu Ramakrishna, Nagammal Neelagandan, Sumantra Chattarji, Ravi. S. Muddashetty   +4 more
doaj   +1 more source

Gingiva-Derived Mesenchymal Stem Cell-Extracellular Vesicles Activate Schwann Cell Repair Phenotype and Promote Nerve Regeneration

Tissue Engineering. Part A, 2019
A fully functional recovery of peripheral nerve injury remains a major challenge and an unmet clinical need. Recent evidence has reported promising therapeutic effects of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) in experimental ...
Qin Mao, P. Nguyen, R. Shanti, S. Shi, Pasha Shakoori, Qunzhou Zhang, A. Le   +6 more
semanticscholar   +1 more source

A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues

Scientific Reports, 2022
Recent research on normal human tissues identified omnipresent clones of cells, driven by somatic mutations known to be responsible for carcinogenesis (e.g., in TP53 or NOTCH1). These new insights are fundamentally changing current tumor evolution models,
Tom Luijts, Kerryn Elliott, Joachim Tetteh Siaw, Joris Van de Velde, Elien Beyls, Arne Claeys, Tim Lammens, Erik Larsson, Wouter Willaert, Anne Vral, Jimmy Van den Eynden   +10 more
doaj   +1 more source