Results 11 to 20 of about 809,436 (268)
Cell therapy for cartilage repair [PDF]
Emerging Topics in Life Sciences, 2021 Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating this technology to the clinic, but it is not without its challenges. These include applying regulations,
Charlotte H. Hulme +6 more
openaire +3 more sources
Reprogramming Cells for Brain Repair [PDF]
Brain Sciences, 2013 At present there are no clinical therapies that can repair traumatic brain injury, spinal cord injury or degenerative brain disease. While redundancy and rewiring of surviving circuits can recover some lost function, the brain and spinal column lack sufficient endogenous stem cells to replace lost neurons or their supporting glia.
Randall D. McKinnon, Alyx T. Guarino
openaire +3 more sources
Stem cells for myocardial repair [PDF]
Thrombosis and Haemostasis, 2010 SummaryThere is a growing interest in the clinical application for stem cell as a novel therapy for treatment of acute myocardial infarction and chronic myocardial ischaemia. The initial premise is the transplanted exogenous stem cells can engraft and integrate with host myocardium for cardiac regeneration.
Liu, Y +4 more
openaire +4 more sources
Heart repair and stem cells [PDF]
The Journal of Physiology, 2006 Of the medical conditions currently being discussed in the context of possible treatments based on cell transplantation therapy, few have received more attention than the heart. Much focus has been on the potential application of bone marrow‐derived cell preparations, which have already been introduced into double‐blind, placebo‐controlled clinical ...
Linda W, van Laake +3 more
openaire +2 more sources
Scientific Reports, 2023 Age-related macular degeneration (AMD) is a complex disease caused by different genetic and environmental risk factors leading to loss of cells in the central part of the retina.
Almar Neiteler +3 more
doaj +1 more source
c-Abl Kinase Is Required for Satellite Cell Function Through Pax7 Regulation
Frontiers in Cell and Developmental Biology, 2021 Satellite cells (SCs) are tissue-specific stem cells responsible for adult skeletal muscle regeneration and maintenance. SCs function is critically dependent on two families of transcription factors: the paired box (Pax) involved in specification and ...
Fabián Montecino +6 more
doaj +1 more source
Bone repair and stem cells [PDF]
Current Opinion in Genetics & Development, 2016 Bones are an important component of vertebrates; they grow explosively in early life and maintain their strength throughout life. Bones also possess amazing capabilities to repair-the bone is like new without a scar after complete repair. In recent years, a substantial progress has been made in our understanding on mammalian bone stem cells.
Noriaki, Ono, Henry M, Kronenberg
openaire +2 more sources
A 3D Cell Death Assay to Quantitatively Determine Ferroptosis in Spheroids
Cells, 2020 The failure of drug efficacy in clinical trials remains a big issue in cancer research. This is largely due to the limitations of two-dimensional (2D) cell cultures, the most used tool in drug screening.
Robin Demuynck +4 more
doaj +1 more source
Transplantation of Bioreactor-Produced Neural Stem Cells into the Rodent Brain
Cell Transplantation, 2006 The development of new cell replacement strategies using neural stem cells (NSC) may provide an alternative and unlimited cell source for clinical neural transplantation in neurodegenerative diseases such as Parkinson's and Huntington's disease.
M. Mcleod Ph.D. +6 more
doaj +1 more source
Cell aging and kidney repair [PDF]
Cell Cycle, 2015 Acute kidney injury (AKI), a rapid loss of renal function, is a major clinical problem associated with a high degree of morbidity and mortality. During AKI, a stressor, such as ischemia-reperfusion (IR), causes tubular cell death, interstitial inflammation and vascular damage.
Nathan, Susnik +2 more
openaire +2 more sources