Results 91 to 100 of about 1,448,565 (190)

Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells

Stem Cell Research & Therapy, 2018
Background Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicity, bone marrow-derived mesenchymal
Sujing Sun, Jun Xiao, Jiahui Huo, Zhijun Geng, Kui Ma, Xiaoyan Sun, Xiaobing Fu   +6 more
doaj   +1 more source

Cells' puncture repair kit [PDF]

The Journal of Cell Biology, 2008
A cell with a torn or perforated membrane has to close the breach fast. To heal wounds inflicted by bacteria, cells rely on endocytosis, [Idone et al.][1] show. ![Figure][2] Endosomes contain either removed bacterial toxins (left) or damaged membrane (right).
openaire   +1 more source

Gain of 20q11.21 in human pluripotent stem cells enhances differentiation to retinal pigment epithelium

Stem Cell Research & Therapy
Background Cell therapies based on human pluripotent stem cells (hPSCs) are in clinical trials with the aim of restoring vision in people with age-related macular degeneration.
Loriana Vitillo, Fabiha Anjum, Zoe Hewitt, Owen Laing, Nidaa A. Ababneh, Duncan Baker, Ivana Barbaric, Peter J. Coffey   +7 more
doaj   +1 more source

Photoporation-mediated spatial intracellular delivery of stem cell-derived cardiomyocytes

MethodsX
Human induced pluripotent stem cell-derived cardiomyocytes (iPSCCMs) are promising candidates for disease modeling and therapeutic purposes, however, non-viral intracellular delivery in these cells remains challenging.
Laurens Léger, Chloë De Clercq, Jeffrey Aalders, Kiara Van Acker-Verberckt, Kevin Braeckmans, Jolanda van Hengel   +5 more
doaj   +1 more source

Roles of constitutively secreted extracellular chaperones in neuronal cell repair and regeneration. [PDF]

Neural Regen Res, 2023
Satapathy S, Wilson MR.
europepmc   +1 more source

A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitvity in a xeroderma pigmentosum patient [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund.Background: Radiotherapy-induced DNA double strand breaks (DSB) are critical cytotoxic lesions.
Abbaszadeh, F, Arlett, CF, Bourton, EC, Clingen, PH, Green, MHL, Makarov, EM, Newbold, RF, Parris, CN, Plowman, PN, Themis, M   +9 more
core  

Reevaluating Golgi fragmentation and its implications in wound repair

Cell Regeneration
The Golgi Apparatus (GA) is pivotal in vesicle sorting and protein modifications within cells. Traditionally, the GA has been described as a perinuclear organelle consisting of stacked cisternae forming a ribbon-like structure.
Chandra Sugiarto Wijaya, Suhong Xu
doaj   +1 more source

Pulsed Electromagnetic Fields Induce Skeletal Muscle Cell Repair by Sustaining the Expression of Proteins Involved in the Response to Cellular Damage and Oxidative Stress. [PDF]

Int J Mol Sci, 2023
Maiullari S, Cicirelli A, Picerno A, Giannuzzi F, Gesualdo L, Notarnicola A, Sallustio F, Moretti B.   +7 more
europepmc   +1 more source

Diminished schwann cell repair responses play a role in delayed diabetes-associated wound healing. [PDF]

Front Physiol, 2022
Zhou S, Wan L, Liu X, Hu D, Lu F, Chen X, Liang F.   +6 more
europepmc   +1 more source

Hormone correction of dysfunctional metabolic gene expression in stem cell-derived liver tissue

Stem Cell Research & Therapy
The increase in metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to metabolic dysfunction-associated steatohepatitis (MASH) is a worldwide healthcare challenge. Heterogeneity between men and women in the prevalence and
Alvile Kasarinaite, Maria Jimenez Ramos, Mariana Beltran-Sierra, Elena F. Sutherland, Pedro Arede Rei, Make Zhao, Ying Chi, Meryam Beniazza, Andrea Corsinotti, Timothy J. Kendall, Neil C. Henderson, Jonathan A. Fallowfield, Philippa T. K. Saunders, David C. Hay   +13 more
doaj   +1 more source