Results 11 to 20 of about 12,836,766 (354)
Cell therapy for cartilage repair [PDF]
Emerging Topics in Life Sciences, 2021 Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating this technology to the clinic, but it is not without its challenges. These include applying regulations,
Charlotte H. Hulme +6 more
openaire +3 more sources
Molecular Autism, 2020 Background Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder.
Shreya Das Sharma +15 more
doaj +1 more source
Nature Communications, 2021 Engineering de novo synapse-like connections between neurons could enhance our understanding of neuronal circuits and how they generate behaviour. The authors present a two-component system that creates synthetic neuromodulatory connections to manipulate
Josh D. Hawk +4 more
doaj +1 more source
Microvesicles as vehicles for tissue regeneration: Changing of the guards [PDF]
, 2016 Purpose of Review: Microvesicles (MVs) have been recognised as mediators of stem cell function, enabling and guiding their regenerative effects. Recent Findings: MVs constitute one unique size class of extracellular vesicles (EVs) directly shed from ...
Davies, R. Wayne +3 more
core +1 more source
Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury
Cellular and Molecular Life Sciences, 2020 The great plasticity of Schwann cells (SCs), the myelinating glia of the peripheral nervous system (PNS), is a critical feature in the context of peripheral nerve regeneration following traumatic injuries and peripheral neuropathies. After a nerve damage,
Gianluigi Nocera, C. Jacob
semanticscholar +1 more source
Reprogramming Cells for Brain Repair [PDF]
Brain Sciences, 2013 At present there are no clinical therapies that can repair traumatic brain injury, spinal cord injury or degenerative brain disease. While redundancy and rewiring of surviving circuits can recover some lost function, the brain and spinal column lack sufficient endogenous stem cells to replace lost neurons or their supporting glia.
Randall D. McKinnon, Alyx T. Guarino
openaire +3 more sources
Tissue Engineering. Part A, 2019 A fully functional recovery of peripheral nerve injury remains a major challenge and an unmet clinical need. Recent evidence has reported promising therapeutic effects of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) in experimental ...
Qin Mao +6 more
semanticscholar +1 more source
NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP
Molecular Brain, 2019 Protein synthesis is crucial for maintaining synaptic plasticity and synaptic signalling. Here we have attempted to understand the role of RNA binding proteins, Fragile X Mental Retardation Protein (FMRP) and Moloney Leukemia Virus 10 (MOV10) protein in ...
Preeti Madhav Kute +4 more
doaj +1 more source
Scientific Reports, 2022 Recent research on normal human tissues identified omnipresent clones of cells, driven by somatic mutations known to be responsible for carcinogenesis (e.g., in TP53 or NOTCH1). These new insights are fundamentally changing current tumor evolution models,
Tom Luijts +10 more
doaj +1 more source
Utilizing osteocyte derived factors to enhance cell viability and osteogenic matrix deposition within IPN hydrogels [PDF]
, 2020 Many bone defects arising due to traumatic injury, disease, or surgery are unable to regenerate, requiring intervention. More than four million graft procedures are performed each year to treat these defects making bone the second most commonly ...
Hoey, David A. +2 more
core +1 more source