Results 61 to 70 of about 214,795 (311)

LncRNA like NMRK2 mRNA functions as a key molecular scaffold to enhance mitochondrial respiration of NONO-TFE3 rearranged renal cell carcinoma in an NAD+ kinase-independent manner [PDF]

, 2023
Yi Chen, Yanwen Lu, Lei Yang, Wenliang Ma, Yuhan Dong, Shuoming Zhou, Ning Liu, Weidong Gan, Dongmei Li   +8 more
openalex   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak [PDF]

, 2023
Dana Sovilj, Cristina Daniela Kelemen, Sarka Dvorakova, Renata Zobalová, Helena Raabová, Ján Kriška, Zuzana Heřmanová, Tomáš Knotek, Miroslava Anděrová, Pavel Klener, Vlada Filimonenko, Jiřı́ Neužil, Ladislav Anděra   +12 more
openalex   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Zinc-Based Nanoparticles, but Not Silicon-Based Nanoparticles, Accumulate in Mitochondria and Promote Cell Death in Liver Cancer Cells

International Journal of Nanomedicine
Joana C Pieretti,1,2 Thaissa L Horne,1 Natalia García-Villasante,1 Amedea B Seabra,2 Jordi Muntané1,3,4 1Institute of Biomedicine of Seville (IBiS), Hospital University “Virgen del Rocío”/CSIC/University of Seville, Seville, Spain; 2Center for Natural ...
Pieretti JC, Horne TL, García-Villasante N, Seabra AB, Muntané J   +4 more
doaj  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Editorial: Computational and Experimental Insights in Redox-Coupled Proton Pumping in Proteins

Frontiers in Chemistry, 2021
Vivek Sharma, Petra Imhof, Petra Hellwig
doaj   +1 more source

Respirometry kinetics of phenol oxidation by Comamonas testosteroni Pb50 under various conditions of nutritional stress

Brazilian Archives of Biology and Technology, 2010
Kinetics of phenol biodegradation using suspended biomass of Comamonas testosteroni Pb50 (monoculture) was measured under conditions of nutrient abundance, limitation, and prolonged cell starvation in a fed-batch reactor, with phenol being the sole ...
Jan Paca, Alena Kosteckova, Leona Pacova, Ales Prell, Martin Halecky, Jan Paca Jr., Marie Stiborova, Evguenii Kozliak, Carlos Ricardo Soccol   +8 more
doaj   +1 more source

Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

, 2021
Michael C Kiritsy, Katelyn McCann, Daniel Mott, Steven M Holland, Samuel M Behar, Christopher M Sassetti, Andrew J Olive   +6 more
openalex   +1 more source