Results 111 to 120 of about 1,800,217 (375)

A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

open access: yesFEBS Letters, EarlyView.
Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston   +7 more
wiley   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

open access: yesFEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt   +8 more
wiley   +1 more source

Separation of accelerated electrons and positrons in the relativistic reconnection

open access: yes, 2007
We study an acceleration of electrons and positrons in the relativistic magnetic field reconnection using a 2.5-D particle-in-cell electromagnetic relativistic code. We consider the model with two current sheets and periodic boundary conditions.
Karlicky, Marian
core   +1 more source

Separation of a binary fluid mixture in a porous horizontal cavity [PDF]

open access: yes, 2008
Thermogravitational separation has, until now, been used in differentially heated vertical cells, called thermogravitational columns (TGCs). The cell can be either a slit or an annular cavity whose two isothermal faces are maintained at different ...
Charrier-Mojtabi, Marie-Catherine   +2 more
core   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

On-chip separation and sensing systems for hydrodynamic chromatography [PDF]

open access: yes, 2002
The feasibility of on-chip analytical separations using planar hydrodynamic chromatography (HDC) in Pyrex-silicon and fused silica chips has been demonstrated.
Blom, Marko Theodoor
core   +2 more sources

Magnetophoretic separation of blood cells at the microscale [PDF]

open access: yesarXiv, 2006
We present a method and model for the direct and continuous separation of red and white blood cells in plasma. The method is implemented at the microscale using a microfluidic system that consists of an array of integrated soft-magnetic elements embedded beneath a microfluidic channel.
arxiv  

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Development of a microfluidic setup for the isolation and imaging of immune cells

open access: yesCurrent Directions in Biomedical Engineering
Specialised cells in the blood play an important role in controlling the immune responses. Thus, these cells are also valuable for the diagnosis and treatment of diseases such as autoimmune disorders and cancer.
Petzold Mandy   +4 more
doaj   +1 more source

Recent Advances and Future Perspectives on Microfluidic Liquid Handling

open access: yesMicromachines, 2017
The interdisciplinary research field of microfluidics has the potential to revolutionize current technologies that require the handling of a small amount of fluid, a fast response, low costs and automation.
Nam-Trung Nguyen   +3 more
doaj   +1 more source

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