Results 11 to 20 of about 224,353 (263)
3D cell sheet structure augments mesenchymal stem cell cytokine production
Scientific Reports, 2021 Mesenchymal stem cells (MSCs) secrete paracrine factors that play crucial roles during tissue regeneration. An increasing body of evidence suggests that this paracrine function is enhanced by MSC cultivation in three-dimensional (3D) tissue-like ...
Sophia Bou-Ghannam +3 more
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Cells, 2021 Articular cartilage defects represent an inciting factor for future osteoarthritis (OA) and degenerative joint disease progression. Despite multiple clinically available therapies that succeed in providing short term pain reduction and restoration of ...
Hallie Thorp +5 more
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Enhancing chondrogenic potential via mesenchymal stem cell sheet multilayering
Regenerative Therapy, 2021 Advanced tissue engineering approaches for direct articular cartilage replacement in vivo employ mesenchymal stem cell (MSC) sources, exploiting innate chondrogenic potential to fabricate hyaline-like constructs in vitro within three-dimensional (3D ...
Hallie Thorp +6 more
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npj Regenerative Medicine, 2021 Knee cartilage does not regenerate spontaneously after injury, and a gold standard regenerative treatment algorithm has not been established. This study demonstrates preclinical safety and efficacy of scaffold-free, human juvenile cartilage-derived ...
Makoto Kondo +10 more
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Temporary Storage of the Human Nasal Tissue and Cell Sheet for Wound Repair
Frontiers in Bioengineering and Biotechnology, 2021 Temporary storage of nasal tissues and nasal cell sheets, which entails transportation between hospitals and cell culture facilities, is an important issue in regenerative medicine.
Yoshiyuki Kasai +5 more
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Gels, 2023 Organ transplantation is the first and most effective treatment for missing or damaged tissues or organs. However, there is a need to establish an alternative treatment method for organ transplantation due to the shortage of donors and viral infections ...
Yoshitaka Miyamoto
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Stem Cell Research & Therapy, 2023 Background Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) sheets have recently attracted attention as an alternative approach to injected cell suspensions for stem cell therapy.
Mitsuyoshi Nakao +7 more
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Science and Technology of Advanced Materials, 2021 A variety of poly(N-isopropylacrylamide) (PIPAAm)-grafted surfaces have been reported for temperature-controlled cell adhesion/detachment. However, the surfaces reported to date need further improvement to achieve good outcomes for both cell adhesion and
Masamichi Nakayama +5 more
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eLife, 2020 Cancer clone evolution takes place within tissue ecosystem habitats. But, how exactly tumors arise from a few malignant cells within an intact epithelium is a central, yet unanswered question.
Ashna Alladin +8 more
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Osteogenic extracellular matrix sheet for bone tissue regeneration [PDF]
European Cells & Materials, 2018 The application of extracellular matrix (ECM) sheets without a scaffold is not extensively reported in bone regenerative medicine. The aim of the present study was to demonstrate that an osteogenic ECM sheet (OECMS) can retain ECM integrity and growth ...
T Onishi +7 more
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