Results 21 to 30 of about 237,743 (307)

Recent Advances in Cell Sheet Engineering: From Fabrication to Clinical Translation. [PDF]

Bioengineering (Basel), 2023
Thummarati P, Laiwattanapaisal W, Nitta R, Fukuda M, Hassametto A, Kino-Oka M.   +5 more
europepmc   +2 more sources

Rapid and effective preparation of clonal bone marrow-derived mesenchymal stem/stromal cell sheets to reduce renal fibrosis

Scientific Reports, 2023
Allogeneic “off-the-shelf” mesenchymal stem/stromal cell (MSC) therapy requires scalable, quality-controlled cell manufacturing and distribution systems to provide clinical-grade products using cryogenic cell banking.
Sumako Kameishi, Celia M. Dunn, Masatoshi Oka, Kyungsook Kim, Yun-Kyoung Cho, Sun U. Song, David W. Grainger, Teruo Okano   +7 more
doaj   +1 more source

Interferon-Gamma Primed Human Clonal Mesenchymal Stromal Cell Sheets Exhibit Enhanced Immunosuppressive Function

Cells, 2022
Mesenchymal stromal cells (MSCs) represent a promising treatment for immune-related diseases due to their diverse immunomodulatory paracrine functions.
Celia M. Dunn, Sumako Kameishi, Yun-Kyoung Cho, Sun U. Song, David W. Grainger, Teruo Okano   +5 more
doaj   +1 more source

Cell sheets in cell therapies [PDF]

Cytotherapy, 2018
This review aims to provide a broad introduction to the use of cell sheets and the role of materials in the delivery of cell sheets to patients within a clinical setting. Traditionally, cells sheets have been, and currently are, fabricated using established and accepted cell culture methods within standard formats (e.g., petri dishes) utilizing ...
Giles T.S. Kirby, Andrew Michelmore, Louise E. Smith, Jason D. Whittle, Robert D. Short   +4 more
openaire   +2 more sources

3D cell sheet structure augments mesenchymal stem cell cytokine production

Scientific Reports, 2021
Mesenchymal stem cells (MSCs) secrete paracrine factors that play crucial roles during tissue regeneration. An increasing body of evidence suggests that this paracrine function is enhanced by MSC cultivation in three-dimensional (3D) tissue-like ...
Sophia Bou-Ghannam, Kyungsook Kim, David W. Grainger, Teruo Okano   +3 more
doaj   +1 more source

Trends in Articular Cartilage Tissue Engineering: 3D Mesenchymal Stem Cell Sheets as Candidates for Engineered Hyaline-Like Cartilage

Cells, 2021
Articular cartilage defects represent an inciting factor for future osteoarthritis (OA) and degenerative joint disease progression. Despite multiple clinically available therapies that succeed in providing short term pain reduction and restoration of ...
Hallie Thorp, Kyungsook Kim, Makoto Kondo, Travis Maak, David W. Grainger, Teruo Okano   +5 more
doaj   +1 more source

Enhancing chondrogenic potential via mesenchymal stem cell sheet multilayering

Regenerative Therapy, 2021
Advanced tissue engineering approaches for direct articular cartilage replacement in vivo employ mesenchymal stem cell (MSC) sources, exploiting innate chondrogenic potential to fabricate hyaline-like constructs in vitro within three-dimensional (3D ...
Hallie Thorp, Kyungsook Kim, Sophia Bou-Ghannam, Makoto Kondo, Travis Maak, David W. Grainger, Teruo Okano   +6 more
doaj   +1 more source

Safety and efficacy of human juvenile chondrocyte-derived cell sheets for osteochondral defect treatment

npj Regenerative Medicine, 2021
Knee cartilage does not regenerate spontaneously after injury, and a gold standard regenerative treatment algorithm has not been established. This study demonstrates preclinical safety and efficacy of scaffold-free, human juvenile cartilage-derived ...
Makoto Kondo, Sumako Kameishi, Kyungsook Kim, Nicolas F. Metzler, Travis G. Maak, Douglas T. Hutchinson, Angela A. Wang, Miki Maehara, Masato Sato, David W. Grainger, Teruo Okano   +10 more
doaj   +1 more source

Temporary Storage of the Human Nasal Tissue and Cell Sheet for Wound Repair

Frontiers in Bioengineering and Biotechnology, 2021
Temporary storage of nasal tissues and nasal cell sheets, which entails transportation between hospitals and cell culture facilities, is an important issue in regenerative medicine.
Yoshiyuki Kasai, Tsunetaro Morino, Izumi Dobashi, Eri Mori, Kazuhisa Yamamoto, Hiromi Kojima   +5 more
doaj   +1 more source

Cryopreservation of Cell Sheets for Regenerative Therapy: Application of Vitrified Hydrogel Membranes

Gels, 2023
Organ transplantation is the first and most effective treatment for missing or damaged tissues or organs. However, there is a need to establish an alternative treatment method for organ transplantation due to the shortage of donors and viral infections ...
Yoshitaka Miyamoto
doaj   +1 more source