Results 241 to 250 of about 3,030,328 (299)

Cell signaling characterization for spatial transcriptomics (ST) data using network analysis. [PDF]

Complex Netw Appl
Javaid A, Frost HR.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Nitroxidative Stress, Cell-Signaling Pathways, and Manganese Porphyrins: Therapeutic Potential in Neuropathic Pain. [PDF]

Int J Mol Sci
Silva ÁJC, de Lavor MSL.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Cilia at the crossroad: convergence of regulatory mechanisms to govern cilia dynamics during cell signaling and the cell cycle. [PDF]

Cell Biosci
Čajánek L, Smite S, Ivashchenko O, Huranova M.   +3 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Role of IGFBP-3 in Human Diseases Relying on Different Cell Signaling Pathways. [PDF]

Adv Biomed Res
Naseri N, Mofid MR.
europepmc   +1 more source

Single-cell signaling network profiling during redox stress reveals dynamic redox regulation in immune cells. [PDF]

Nat Commun
Wang YC, Wu PH, Ting WC, Wang YF, Yang MH, Su TH, Su JY, Sun HI, Huang WM, Tsai PL, Wernig G, Ho PC, Wang L, Wu CT, Chang YL, Chen TC, Meng TC, Chang YM, Lai SL, Li CW, Ko TM, Yang KC, Chang YJ, Chern Y, Kuo MC, Huang YT, Tzeng YS, Tang JL, Chen SY.   +28 more
europepmc   +1 more source

Amplitude and frequency encoding result in qualitatively distinct informational landscapes in cell signaling. [PDF]

Sci Rep
Givré A, Colman-Lerner A, Ponce Dawson S.   +2 more
europepmc   +1 more source

RAB23 facilitates clathrin-coated nascent vesicle formation at the plasma membrane and modulates cell signaling. [PDF]

Cell Mol Life Sci
Hasan MR, Takatalo M, Nieminen P, Rice R, Mustonen T, Rice DP.   +5 more
europepmc   +1 more source