Results 151 to 160 of about 2,922,174 (317)

How one nutrient controls cell size. [PDF]

Elife
Montero A, Finley LWS.
europepmc   +1 more source

Subclassification of prostate cancer circulating tumor cells by nuclear size reveals very small nuclear circulating tumor cells in patients with visceral metastases

, 2015
Jie‐Fu Chen, Hao Ho, Jake Lichterman, Yi‐Tsung Lu, Yang Zhang, Mitch A. Garcia, Shang‐Fu Chen, An‐Jou Liang, Elisabeth Hodara, Haiyen E. Zhau, Shuang Hou, Rafi S. Ahmed, Daniel Luthringer, Jiaoti Huang, Ker‐Chau Li, Leland W.K. Chung, Zunfu Ke, Hsian‐Rong Tseng, Edwin M. Posadas   +18 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

LncRNA CISTR-ACT regulates cell size in human and mouse by guiding FOSL2. [PDF]

Nat Commun
Kiriakopulos K, Soleimanpour K, McMurray BJ, Moke BI, Chalmers JJ, Mokhtaridoost M, Newton JD, De Young T, Delfosse K, Ahmed M, Wong CJ, Stricker S, Li Y, Nieman BJ, Gingras AC, Justice MJ, Lefebvre JL, Maass PG.   +17 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

ATP increases murine neuroblastoma cell size through a PANX1- and macropinocytosis-dependent mechanism. [PDF]

Biol Open
Boyce AKJ, You H, Wicki-Stordeur LE, Swayne LA.   +3 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Fusion of GFP to the Carboxyl Terminus of Connexin43 Increases Gap Junction Size in HeLa Cells [PDF]

, 2003
Andrew W. Hunter, Jane Jourdan, Robert G. Gourdie   +2 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Repeatability of in vivo MR cytometry for measuring cell size and density in healthy human livers. [PDF]

Magn Reson Imaging
Jiang X, Jin C, Kang H, Piantek G, Zu Z, Gore JC, Xu J.   +6 more
europepmc   +1 more source