Results 211 to 220 of about 2,922,174 (317)

Intracellular diffusion in the cytoplasm increases with cell size in fission yeast. [PDF]

Mol Biol Cell
Tan C, Lanz MC, Swaffer M, Skotheim J, Chang F.   +4 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Cell size modulates ferroptosis susceptibility

Zatulovskiy E, Murray MB, Zhang S, Dixon SJ, Skotheim JM.   +4 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Neuron-specific homologous coding genes and non-coding regulatory regions are the most conserved amongst amniotes despite neuron-specific cell size diversity. [PDF]

Sci Rep
Xu L, Herculano-Houzel S.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Consideration of Grid Cell Size to Represent Stream Networks for the Conterminous United States. [PDF]

Ground Water
Fleming BJ, Belitz K, Killian CD.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations. [PDF]

PLoS Comput Biol
Vanoni M, Palumbo P, Papa F, Busti S, Gotti L, Wortel M, Teusink B, Orlandi I, Pessina A, Airoldi C, Brambilla L, Vai M, Alberghina L.   +12 more
europepmc   +1 more source

Streamlined measurement of chimeric antigen receptor T-cell concentration, size, viability and two-color phenotyping during manufacturing [PDF]

Raymone Pajarillo, Luca Paruzzo, Alberto Carturan, Ositadimma Ugwuanyi, Griffin White, Puneeth Guruprasad, Hatcher J. Ballard, Ruchi P. Patel, Yunlin Zhang, Yong Gu Lee, Seok Jae Albert Hong, Gregory M. Dittami, Marco Ruella   +12 more
openalex   +1 more source