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Why size matters: altering cell size
Current Opinion in Genetics & Development, 2002Several genes involved in growth control have lately been demonstrated to exhibit more potent effects on cell size than on cell proliferation. Many of these genes direct protein and ribosomal synthesis, highlighting the interdependence between cell size and macromolecular content.
Bruce A. Edgar, Leslie J. Saucedo
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BioEssays, 2000
For many years, it has been believed that diffusion is the principle motive force for distributing molecules within the cell. Yet, our current information about the cell makes this improbable. Furthermore, the argument that limitations responsible for the relative constancy of cell size--which seldom varies by more than a factor of 2, whereas organisms
Paul S. Agutter, Denys N. Wheatley
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For many years, it has been believed that diffusion is the principle motive force for distributing molecules within the cell. Yet, our current information about the cell makes this improbable. Furthermore, the argument that limitations responsible for the relative constancy of cell size--which seldom varies by more than a factor of 2, whereas organisms
Paul S. Agutter, Denys N. Wheatley
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Current Opinion in Genetics & Development, 2000
Over the past 25 years, the genetic control of cell size has mainly been addressed in yeast, a single-celled organism. Recent insights from Drosophila have shed light on the signalling pathways responsible for adjusting and maintaining cell size in metazoans.
Stocker, H, Hafen, E
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Over the past 25 years, the genetic control of cell size has mainly been addressed in yeast, a single-celled organism. Recent insights from Drosophila have shed light on the signalling pathways responsible for adjusting and maintaining cell size in metazoans.
Stocker, H, Hafen, E
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Science, 2009
Control over cell division depends on coordinately functioning sensors of cell size and age.
Bruce A. Edgar, Kerry J. Kim
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Control over cell division depends on coordinately functioning sensors of cell size and age.
Bruce A. Edgar, Kerry J. Kim
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Size Distribution of Lymph Cells
Scandinavian Journal of Haematology, 1970With the presently available equipment (Coulter counter in combination with a multichannel analyzer) reproducible and biologically meaningfull cell volume distributions can be recorded within a short time (2–3 min) from a large sample of cells (105). Lymph cells remain nearly stable for 2–3 hours in lymph with heparin as anticoagulant. On dilution with
Hp. Schnappauf +3 more
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Science, 2020
Cell Cycle Efforts continue to uncover the long-sought mechanism by which cells coordinate growth and cell division to maintain a constant size. Zatulovskiy et al. propose that human cells sense the concentration of the retinoblastoma family protein Rb. Rb itself acts on transcription factors to inhibit progression through the cell cycle. As cells grow,
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Cell Cycle Efforts continue to uncover the long-sought mechanism by which cells coordinate growth and cell division to maintain a constant size. Zatulovskiy et al. propose that human cells sense the concentration of the retinoblastoma family protein Rb. Rb itself acts on transcription factors to inhibit progression through the cell cycle. As cells grow,
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Developmental Genetics, 1988
AbstractCellular slime mold amoebae have become a model system for the study of cell motility and the cytoskeleton. A basic problem which all cells face that involves the cytoskeleton is how to control their size. The varied ways in which cellular slime mold amoebae change their cell size‐by changing the size at which division occurs, by cell fusion ...
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AbstractCellular slime mold amoebae have become a model system for the study of cell motility and the cytoskeleton. A basic problem which all cells face that involves the cytoskeleton is how to control their size. The varied ways in which cellular slime mold amoebae change their cell size‐by changing the size at which division occurs, by cell fusion ...
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Annual Review of Genetics, 2019
The genetic control of the characteristic cell sizes of different species and tissues is a long-standing enigma. Plants are convenient for studying this question in a multicellular context, as their cells do not move and are easily tracked and measured from organ initiation in the meristems to subsequent morphogenesis and differentiation.
Marco D'Ario, Robert Sablowski
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The genetic control of the characteristic cell sizes of different species and tissues is a long-standing enigma. Plants are convenient for studying this question in a multicellular context, as their cells do not move and are easily tracked and measured from organ initiation in the meristems to subsequent morphogenesis and differentiation.
Marco D'Ario, Robert Sablowski
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Dielectrophoresis of cell-size liposomes
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1994The dielectrophoresis (DEP) behavior of cell size liposomes were studied in the frequency range from 20 kHz to 3 MHz. Liposomes in the size of about 10 microns in diameter were made from egg phosphatidylcholine (PC), egg phosphatidylethanolamine (PE), egg phosphatidylglycerol (PG) and brain phosphatidylserine (PS).
N.G. Stoicheva, S.W. Hui
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A model of cell size regulation
Journal of Theoretical Biology, 1965The kinetics of cell growth and the effects of ploidy and genetic factors on cell size are reviewed. The following model of the mechanism regulating cell size is proposed. Unstable molecules (R1) are present in a constant equilibrium quantity per cell, the quantity being proportional to the amount of DNA in the nucleus.
Arlene Bensam, Motoyosi Sugita, M. Yǎs
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