Results 121 to 130 of about 319,319 (301)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A hybrid dielectrophoretic and hydrophoretic microchip for particle sorting using integrated prefocusing and sorting steps

, 2015
This work explores dielectrophoresis (DEP)-active hydrophoresis in sorting particles and cells. The device consists of prefocusing region and sorting region with great potential to be integrated into advanced lab-on-a-chip bioanalysis devices.
George Lovrecz, Yonggang Zhu, Lovrecz, George, Du, Haiping, Zhu, Yonggang, Yan, Sheng, Alici, Gursel, Gursel Alici, Jun Zhang, Yuan Yuan, Yuan, Yuan, Weihua Li, Haiping Du, Li, Weihua, Zhang, Jun, Sheng Yan   +15 more
core   +1 more source

Paxillin is required for cell-substrate adhesion, cell sorting and slug migration during Dictyostelium development [PDF]

, 2005
Paxillin is a key regulatory component of focal adhesion sites, implicated in controlling cell-substrate interactions and cell movement. We analyse the function of a Dictyostelium discoideum paxillin homologue, PaxB, which contains four highly conserved ...
Leonard Bosgraaf, Haastert, Peter J. van,, Weijer, Cornelis J.,, Bukharova, Tanya,, Bosgraaf, Leonard, Gertrud Weijer, Dirk Dormann, van Haastert, Peter J., Dormann, Dirk, Cornelis J. Weijer, Tanya Bukahrova, Bosgraaf, Leonard,, Dormann, Dirk,, Weijer, Gertrud, Peter J. van Haastert, Weijer, Gertrud,, Bukharova, Tanya, Weijer, Cornelis J.   +17 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hydrodynamic Microparticle Separation Mechanism Using Three-Dimensional Flow Profiles in Dual-Depth and Asymmetric Lattice-Shaped Microchannel Networks

Micromachines, 2019
We herein propose a new hydrodynamic mechanism of particle separation using dual-depth, lattice-patterned asymmetric microchannel networks. This mechanism utilizes three-dimensional (3D) laminar flow profiles formed at intersections of lattice channels ...
Takuma Yanai, Takatomo Ouchi, Masumi Yamada, Minoru Seki   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

In-air microfluidic sorting of single cells on multiple paths

Microsystems & Nanoengineering
Sorting of desired single cells from a cell population is crucial for many applications in biology and biomedicine that require analysis at the cellular level. Microfluidic dielectrophoresis (DEP)-based single-cell sorting method has been demonstrated as
Yuhe Chen, Ziyang Wang, Rui Tong, Congying Liu, Xiaojin Yang, Pengfei Zhang   +5 more
doaj   +1 more source

Increasing Cell Sorting Recovery Using the Simple “Three-Puddle Method”

Recovery is a key performance parameter in cell sorters, a metric that assesses the match between the number of particles reported as sorted by the instrument and the actual number of particles gathered in the collection vessels.
Henderson, Carl, Castro-Pérez, M. J.
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation

, 2006
in mammalian cells, epidermal growth factor (EGF) stimulation promotes multivesicular body (MVB) formation and inward vesiculation within MVB. Annexin 1 is required for EGF-stimulated inward vesiculation but not MVB formation, demonstrating that MVB ...
C. E. Futter, M. Razi, Razi, M, Futter, CE   +3 more
core