Results 151 to 160 of about 319,319 (301)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Cell Sorting Using Diagonal Bottom Grooves in a Microchannel [PDF]

Journal of Systemics, Cybernetics and Informatics
Cell shape is related to cell function. For the purpose of cell sorting based on shape, a channel with diagonal grooves on the bottom was designed. A cell suspension was poured into a channel created by micromachining, and cell sorting according to shape
Kota Yamamoto, Shigehiro Hashimoto
doaj  

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Single cell isolation and DNA analysis from circulating tumor cells using a self sorting nanowell plate

, 2015
Introduction: The heterogeneity of tumor cells dictates the need for analysis at the single cell level. In addition, gene expression can be altered during the course of the disease and is accelerated under the influence of therapy.
Arjan GJ Tibbe, Terstappen, Leon W.M.M., Cees J.M. van Rijn, Leon W.M.M Terstappen, Hien D. Tong, Stoecklein, Nikolas H., Rui Neves, Stevens, Michiel, Joost F. Swennenhuis, Nikolas H. Stoecklein, Tibbe, Arjan G.J., Michiel Stevens, Tong, Hien D., van Rijn, Cees J.M., Neves, Rui, Swennenhuis, Joost F.   +15 more
core   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

A novel stem cell tag-less sorting method.

, 2009
Growing interest in stem cell research has led to the development of a number of new methods for isolation. The lack of homogeneity in stem cell preparation blurs standardization, which however is recommended for successful applications. Among stem cells,
MARCHIONNI, COSETTA, RESCHIGLIAN, PIERLUIGI, BONSI, LAURA, ALVIANO, FRANCESCO, SCALINCI, SERGIO ZACCARIA, Scalinci, Sergio, ZATTONI, ANDREA, Tazzari P. L., COSTA, ROBERTA, Bagnara, Gian, LANZONI, GIACOMO, DI CARLO, ARIANNA, BAGNARA, GIAN PAOLO, Pagliaro P., Tazzari, Pier, RODA, BARBARA, FRANCHINA, MICHELE, Ricci F., Ricci, Francesca, Pagliaro, Pasqualepaolo   +19 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Coral cell separation and isolation by fluorescence-activated cell sorting (FACS)

, 2017
Background Generalized methods for understanding the cell biology of non-model species are quite rare, yet very much needed. In order to address this issue, we have modified a technique traditionally used in the biomedical field for ecological and ...
Rosental, Benyamin, Fernhoff, Nathaniel, Nathaniel Fernhoff, Nikki Traylor-Knowles, Traylor-Knowles, Nikki, Zhanna Kozhekbaeva, Benyamin Rosental, Tsai, Jonathan M, Jonathan M. Tsai, Kozhekbaeva, Zhanna   +9 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source