Results 101 to 110 of about 3,396,679 (311)

Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages

Journal of Lipid Research, 2004
It was reported previously that ceramide-1-phosphate (Cer-1-P) is mitogenic for fibroblasts (Gómez-Muñoz, A., P. A. Duffy, A. Martin, L. O'Brien, H-S. Byun, R. Bittman, and D. N. Brindley. 1995. Mol. Pharmacol. 47: 883–889; Gómez-Muñoz, A., L. M.
Antonio Gómez-Muñoz, Jennifer Y. Kong, Bill Salh, Urs P. Steinbrecher   +3 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Survival outcome and EMT suppression mediated by a lectin domain interaction of Endo180 and CD147 [PDF]

, 2014
Epithelial cell-cell contacts maintain normal glandular tissue homeostasis, and their breakage can trigger epithelial-to-mesenchymal transition (EMT), a fundamental step in the development of metastatic cancer.
Darby, Steven, Gaughan, Luke, Gronau, Julian H., Mauri, Francesco, Minamidate, Ai, Robson, Craig, Rodriguez-Teja, Mercedes, Sturge, Justin, Waxman, Jonathan   +8 more
core   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Deep segmentation networks predict survival of non-small cell lung cancer [PDF]

, 2019
Non-small-cell lung cancer (NSCLC) represents approximately 80-85% of lung cancer diagnoses and is the leading cause of cancer-related death worldwide. Recent studies indicate that image-based radiomics features from positron emission tomography-computed
Allen, Bryan, Baek, Stephen, Baek, Stephen, Buatti, John, Cabel, Katherine, Diehn, Maximilian, Gannon, Maggie, He, Yusen, Kim, Yusung, Loo, Billy, Plichta, Kristin, Seyedin, Steven, Smith, Brian, Sun, Zhiyu, Tong, Ling, Wu, Jia, Wu, Xiaodong   +16 more
core   +2 more sources

POSC20 Treatment Patterns and Survival Among Patients With Advanced Renal Cell Cancer: Results of a Nationwide Cohort Study in Denmark [PDF]

, 2022
Signe Sørup, Bianka Darvalics, Mairead Kearney, SH Mahmoudpour, Francesca Kolitsopoulos, Mads Agerbæk, Deirdre Cronin‐Fenton   +6 more
openalex   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. [PDF]

, 2012
The altered metabolism of cancer can render cells dependent on the availability of metabolic substrates for viability. Investigating the signaling mechanisms underlying cell death in cells dependent upon glucose for survival, we demonstrate that glucose ...
Graeber, Thomas G, Graham, Nicholas A, Kohli, Bitika, Komisopoulou, Evangelia, Lo, Roger S, Mellinghoff, Ingo K, Mischel, Paul S, Ribas, Antoni, Tahmasian, Martik, Teitell, Michael A, Vivanco, Igor, Wu, Hong, Zhu, Maggie   +12 more
core  

Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo [PDF]

, 2007
Endothelial cell survival is indispensable to maintain endothelial integrity and initiate new vessel formation. We investigated the role of SHP-2 in endothelial cell survival and angiogenesis in vitro as well as in vivo.
Alavi A, Barbara Walzog, Bennett AM, Brooks PC, Chan RJ, Chang F, Chen J, Christian Plank, Crompton T, Cunnick JM, Distler JH, Florian Krötz, Frisch SM, Hadari YR, Hae-Young Sohn, Hanna Mannell, Hu Y, Huang P, Ivins Zito C, Kontaridis MI, Krotz F, Krotz F, Krotz F, Krotz F, Leopold Groesser, Munoz-Chapuli R, Neel BG, Neel BG, Nicole Hellwig, Noguchi T, Nor JE, Ong SH, O’Brien CD, Papetti M, Plank C, Qi JH, Qi JH, Qu CK, Ren Y, Saxton TM, Shi ZQ, Slater EP, Tang TL, Thakker GD, Tomanek RJ, Torsten Gloe, Ulrich Pohl, Wu CJ, Yart A, Zhang SQ, Zhang SQ   +50 more
core   +1 more source

153 High expression of tertiary lymphoid structure gene signatures is associated with improved survival in head and neck squamous cell carcinoma patients treated with immune checkpoint blockade [PDF]

, 2023
Merzu Belete, Meijian Guan, Han Si, Brandon W. Higgs, Sriram Sridhar   +4 more
openalex   +1 more source