Results 101 to 110 of about 14,964,075 (408)

Data-driven quantification of robustness and sensitivity of cell signaling networks [PDF]

, 2013
Robustness and sensitivity of responses generated by cell signaling networks has been associated with survival and evolvability of organisms. However, existing methods analyzing robustness and sensitivity of signaling networks ignore the experimentally observed cell-to-cell variations of protein abundances and cell functions or contain ad hoc ...
arxiv   +1 more source

Targeting tachykinin receptors in neuroblastoma [PDF]

, 2016
Neuroblastoma is the most common extracranial tumor in children. Despite aggressive multimodal treatment, high-risk neuroblastoma remains a clinical challenge with survival rates below 50%.
Althoff, Kristina, Astrahanseff, Kathy, Beckers, Anneleen, Bergmann, Andreas, De Preter, Katleen, Eggert, Angelika, Henssen, Anton G, Odersky, Andrea, Schramm, Alexander, Schulte, Johannes H, Schäfers, Simon, Seiler, Marleen, Speleman, Franki, Struck, Joachim, Szymansky, Annabell   +14 more
core   +3 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Response of mouse epidermal cells to single doses of heavy-particles [PDF]

, 1972
The survival of mouse epidermal cells to heavy-particles has been studied In Vivo by the Withers clone technique. Experiments with accelerated helium, lithium and carbon ions were performed.
Leith, J. T., Schilling, W. A., Welch, G. P.   +2 more
core   +1 more source

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. [PDF]

, 2017
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells.
Berens, Michael E, Bole, Dhruv, Dhruv, Harshil D, Eaton, John K, Galeas, Jacqueline, Hangauer, Matthew J, Matov, Alexandre, McCormick, Frank, McManus, Michael T, Ryan, Matthew J, Schreiber, Stuart L, Viswanathan, Vasanthi S   +11 more
core   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Novel Radiomic Feature for Survival Prediction of Lung Cancer Patients using Low-Dose CBCT Images [PDF]

arXiv, 2020
Prediction of survivability in a patient for tumor progression is useful to estimate the effectiveness of a treatment protocol. In our work, we present a model to take into account the heterogeneous nature of a tumor to predict survival. The tumor heterogeneity is measured in terms of its mass by combining information regarding the radiodensity ...
arxiv  

Predicting cell stress and strain during extrusion bioprinting [PDF]

arXiv, 2022
Bioprinting of living cells can cause major shape deformations, which may severely affect cell survival and functionality. While the shear stresses occurring during cell flow through the printer nozzle have been quantified to some extent, the extensional stresses occurring as cells leave the nozzle into the free printing strand have been mostly ignored.
arxiv  

Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival

Cell Death and Disease, 2015
The survival of a cell depends on its ability to meet its energy requirements. We hypothesized that the mitochondrial reserve respiratory capacity (RRC) of a cell is a critical component of its bioenergetics that can be utilized during an increase in ...
Jessica Pfleger, Minzhen He, M. Abdellatif   +2 more
semanticscholar   +1 more source

Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest [PDF]

, 2015
Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently accompanied by multinucleation; however, the origin of this is unknown.
Adams, Peter D., Athineos, Dimitris, Berger, Shelley L., Blyth, Karen, Brock, Claire, Clark, William, Cole, John J., Dikovskaya, Dina, Hewitt, Rachael N., Karim, Saadia A., Leach, Joshua D. G., Marchesi, Francesco, Mason, Susan M., McGarry, Lynn, Morton, Jennifer P., Nixon, Colin, Sammons, Morgan A., Tait, Stephen W., van Tuyn, John, Wu, Hong, Zhu, Jiajun   +20 more
core   +2 more sources