Results 281 to 290 of about 593,168 (347)

Cell surface protein and neoplastic transformation

Trends in Biochemical Sciences, 1976
A major fibroblast glycoprotein that is diminished after malignant transformation has been isolated and partially characterized. Reconstitution experiments indicate that the glycoprotein helps maintain normal cell shape, adhesion, and contact inhibition of movement.
Kenneth M. Yamada, Ira Pastan
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The Neoplastic Transformation of SCID Cells by Radiation

Radiation Research, 1999
Severe combined immunodeficiency (SCID) cells are hypersensitive to killing by ionizing radiation because of deregulation of DNA-dependent protein kinase (DNA-PK) and a concomitant deficiency in the repair of DNA double-strand breaks. The effect of this condition on the neoplastic transformation of SCID fibroblasts, designated SCID 3T1, has been ...
M, Lun, R L, Wells, S, Lang, N, Chawapun, M M, Elkind   +4 more
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Neoplastic transformation of primary tracheal epithelial cell cultures

Carcinogenesis, 1983
Primary cultures of rat tracheal epithelial cells were treated with the chemical carcinogen N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) to quantitatively study the early events during neoplastic transformation. Epithelial cells were dissociated from tracheas of specific-pathogen-free Fischer-344 rats and were plated on collagen-coated tissue culture ...
S B, Pai, V E, Steele, P, Nettesheim
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Quantitative Neoplastic Transformation in C3H/10T1/2 Cells

1985
The development of mammalian cell culture systems in which neoplastic transformation can be induced by exposure to chemical and physical carcinogens provided a major stimulus to the study of carcinogenic mechanisms. Furthermore, the potential ability to quantitate the induction of neoplasia on a per cell basis has allowed the study of factors ...
J S, Bertram, J E, Martner
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PD-1 Expression in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) and Large B-cell Richter Transformation (DLBCL-RT): A Characteristic Feature of DLBCL-RT and Potential Surrogate Marker for Clonal Relatedness

American Journal of Surgical Pathology, 2018
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a low-grade B-cell neoplasm and ∼2% to 9% patients develop an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (Richter transformation, DLBCL-RT). Programmed death-1 (PD-
R. He, W. Ding, D. Viswanatha, Dong Chen, M. Shi, D. V. Van Dyke, Shulan Tian, L. Dao, S. Parikh, T. Shanafelt, T. Call, S. Ansell, J. Leis, M. Mai, C. Hanson, K. Rech   +15 more
semanticscholar   +1 more source

Epigenetic Transformation by RNA from Human Neoplastic Cells

Oncology, 1973
The study of biologic properties of nucleic acids from either normal or malignant cells transcends the search for subviral infectivity. The differing results obtained in studying the behavior of nucleic acids from human malignant cells on primary cultures are critically reviewed in the light of the methodology involved.
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Transforming growth factors and control of neoplastic cell growth

Journal of Cellular Biochemistry, 1987
AbstractTransforming growth factors (TGFs) are peptides that affect the growth and phenotypic of cultured cells and bring about in nonmalignant fibroblastic cells phenotypic properties that resemble those of malignant cells. Two types of TGFs have been well characterized.
J, Keski-Oja, E B, Leof, R M, Lyons, R J, Coffey, H L, Moses   +4 more
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Cell Surfaces in Neoplastic Transformation

1971
Publisher Summary This chapter describes the properties, and the chemical and physiological aspects of cell surfaces in neoplastic transformation. Immunological surface disparities between normal and tumor cells have been studied for decades, while attempts to bring them into the realm of biochemistry have been extremely rare.
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Neoplastic transformation of rabbit cells by murine sarcoma viruses

International Journal of Cancer, 1982
AbstractNeoplastic transformation of rabbit cells by Kirsten murine sarcoma virus (Ki‐MSV), the Ki‐MSV pseudotype of baboon endogenous virus (Ki‐MSV[BaEV]) and the Moloney‐MSV pseudotype of feline leukemia virus (M‐MSV[FeLV]) is reported. Rabbit cells can be readily transformed by Ki‐MSV, Ki‐MSV(BaEV) and M‐MSV(FeLV). Rabbit cells transformed by Ki‐MSV
Rhim, J S, Bedigian, H G, Fox, R R
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Neoplastic cell transformation by high-LET radiation: Molecular mechanisms

Advances in Space Research, 1989
Experimental data on molecular mechanisms are essential for understanding the bioeffects of radiation and for developing biophysical models, which can help in determining the shape of dose-response curves at very low doses, e.g., doses less than 1 cGy. Although it has been shown that ionizing radiation can cause neoplastic cell transformation directly,
T C, Yang, L M, Craise, M T, Mei, C A, Tobias   +3 more
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