Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models [PDF]
Computational and Structural Biotechnology Journal, 2022 Organoid modeling is a powerful, robust and efficient technology faithfully preserving physiological and pathological characteristics of tissues of origin.
Hua Zhao +4 more
doaj +2 more sources
Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation [PDF]
eLife, 2021 Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock +9 more
doaj +2 more sources
Gastric Hyperplastic Polyps: A Benign Entity? Analysis of Recurrence and Neoplastic Transformation in a Cohort Study [PDF]
GE: Portuguese Journal of Gastroenterology, 2021 Introduction: Hyperplastic polyps represent 30–93% of all gastric epithelial polyps. They are generally detected as innocuous incidental findings; however, they have a risk of neoplastic transformation and recurrence.
Mafalda João +7 more
doaj +2 more sources
Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation [PDF]
Nature Communications, 2023 The dysregulation of the m6A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 ...
An Xu +32 more
doaj +2 more sources
Radiation-Induced Neoplastic Transformation , Hormesis and Risk Assessment
Dose-Response, 2007 Dose-response curves for various low-LET radiation sources have consistently been demonstrated to be J-shaped for the cancer-relevant endpoint of neoplastic transformation in vitro.
J. Leslie Redpath PhD, Eugene Elmore PhD
doaj +2 more sources
Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence [PDF]
Scientific Reports, 2021 Much in vivo evidence indicates that cyclooxygenase-2 (COX-2) is deeply involved in tumorigenesis. Although it has been proposed that COX-2-derived pro-inflammatory prostanoids mediate the tumorigenic activity of COX-2, the tumorigenic mechanisms of COX ...
Hyeon Ju Lee +3 more
doaj +2 more sources
FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks [PDF]
Frontiers in Cell and Developmental BiologyPurposeFOS-like antigen 1 (FRA1), encoded by FOSL1, is an inducible subunit of the AP-1 transcription factor complex and regulates gene expression in response to proliferative and environmental cues.
Wuroud Al-Khayyat +14 more
doaj +2 more sources
Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients. [PDF]
Sci Rep, 2020 Gastric hyperplastic polyps (GHPs) have a potential risk of neoplastic transformation, but the responsible mechanisms have not yet been established. We conducted a study involving 55 patients (33 female) who had undergone endoscopic or surgical resection
Hu H +4 more
europepmc +2 more sources
Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation [PDF]
Nature Communications, 2021 The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D ...
Roser Vilarrasa-Blasi +19 more
doaj +2 more sources
Marine Drugs, 2016 Guanidine alkaloids from sponges Monanchora spp. represent diverse bioactive compounds, however, the mechanisms underlying bioactivity are very poorly understood.
Sergey A. Dyshlovoy +13 more
doaj +3 more sources