Results 1 to 10 of about 383,457 (302)

Cytoplasmic Beta and Gamma Actin Isoforms Reorganization and Regulation in Tumor Cells in Culture and Tissue

Frontiers in Pharmacology, 2022
The cytoplasmic actin isoforms (β- and γ-actins) contribute greatly to cellular processes such as cel-cell and cell-matrix interactions, as well as cell polarization, motility and division. Distinct isoforms modulations are linked to serious pathologies,
V. B. Dugina, V. B. Dugina, G. S. Shagieva, P. B. Kopnin   +3 more
doaj   +1 more source

Barrett's esophagus: The pathomorphological and molecular genetic keystones of neoplastic progression

Cancer Medicine, 2022
Barrett's esophagus is a widespread chronically progressing disease of heterogeneous nature. A life threatening complication of this condition is neoplastic transformation, which is often overlooked due to lack of standardized approaches in diagnosis ...
Ksenia S. Maslyonkina, Alexandra K. Konyukova, Darya Y. Alexeeva, Mikhail Y. Sinelnikov, Liudmila M. Mikhaleva   +4 more
doaj   +1 more source

Functions of BLM Helicase in Cells: Is It Acting Like a Double-Edged Sword?

Frontiers in Genetics, 2021
DNA damage repair response is an important biological process involved in maintaining the fidelity of the genome in eukaryotes and prokaryotes. Several proteins that play a key role in this process have been identified.
Ekjot Kaur, Ritu Agrawal, Sagar Sengupta
doaj   +1 more source

Genome-wide screening of tumor suppressor genes in oncogenic transformation of normal lung epithelial cells and preliminary validation in sample databases

Di-san junyi daxue xuebao, 2022
Objective To identify new human lung cancer suppressors in a genome-wide screening library during neoplastic transformation of normal human lung epithelial cells using CRISPR/Cas9-mediated genome editing, and preliminarily validate the Results in non ...
ZHAO Binyu, ZHANG Junlei, WANG Jiaqi, RUAN Yan, ZHANG Yue, LIU Lianlian   +5 more
doaj   +1 more source

Absence of a dose-rate effect in the transformation of C3H 10T1/2 cells by α-particles [PDF]

, 1987
The findings of Hill et al. (1984) on the greatly enhanced transformation frequencies at very low dose rates of fission neutrons induced us to perform an analogous study with -particles at comparable dose rates. Transformation frequencies were determined
Balcer-Kubiczek E.K., Barendsen G.W, Barendsen G.W., Borek C., Burch P.R.J., Elkind M.M., Hall E.J., Han A., Han A., Hill C.K., Hill C.K., Hill C.K., Lloyd E.L., Miller R.C., Miller R.C., Reznikoff C., Robertson J.B., Roos H., Rossi H.H., Terzaghi M., Yang T.   +20 more
core   +1 more source

Emerging roles of telomeric chromatin alterations in cancer [PDF]

, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria, Cacchione, Stefano, Rizzo, Angela   +2 more
core   +1 more source

Neoplastic transformation of mouse C3H 10T1/2 and Syrian hamster embryo cells by heavy ions [PDF]

, 1989
C3H 10T1/2 mouse-embryo fibroblasts were used for transformation experiments to study the effectiveness of various heavy ions with energies up to 20 MeV/u and LET values from 170 to 16.000 keV/μm.
A.M. Kellerer, Balcer-Kubiczek, Barendsen, Borek, Borek, Chomczynski, G. Ponsel, Hall, Han, Han, Hieber, Hill, K. Trutschler, Kraft, L. Hieber, Lloyd, Miller, Miller, Reznikoff, Robertson, S. Fenn, Schaeffer, Terzaghi, Wulf, Yang   +24 more
core   +1 more source

Mucoepidermoid Carcinoma Superimposed on a Warthin's Tumor: A Case Report and Review of the Literature [PDF]

Iranian Journal of Otorhinolaryngology, 2021
Introduction: Warthin's tumor (WT) is the second most common neoplasm of the parotid gland and consists of two components, including lymphoid stroma and glandular epithelium.
Shirin Taraz-Jamshidi, Samaneh Mahjouri, Leila Vazifeh-Mostaan   +2 more
doaj   +1 more source

Dbl oncogene expression in MCF-10 A epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion. [PDF]

, 2015
The proteins of the Dbl family are guanine nucleotide exchange factors (GEFs) of Rho GTPases and are known to be involved in cell growth regulation. Alterations of the normal function of these proteins lead to pathological processes such as developmental
Bosco MC, Cabodi S, Donnini S, Eva A., Finetti F, MANCINI, Patrizia, Ognibene M, Segalerba D, TORRISI, Maria Rosaria, Vanni C, Varesio L   +10 more
core   +1 more source

Clonal dynamics of progressive neoplastic transformation [PDF]

Proceedings of the National Academy of Sciences, 1999
In a recent study, we found that newly isolated clones of NIH 3T3 mouse cells undergo neoplastic transformation more readily than uncloned cultures from which they were derived. After eleven low-density passages (LDPs), most of the 29 clones produced lightly stained early-stage transformed foci when grown to confluence in a primary assay for ...
M, Chow, H, Rubin
openaire   +2 more sources