Results 31 to 40 of about 331,839 (297)

Pleiotropic Role of HSF1 in Neoplastic Transformation [PDF]

Current Cancer Drug Targets, 2014
HSF1 (Heat Shock transcription Factor 1) is the main transcription factor activated in response to proteotoxic stress. Once activated, it induces an expression of heat shock proteins (HSPs) which enables cells to survive in suboptimal conditions. HSF1 could be also activated by altered kinase signaling characteristic for cancer cells, which is a ...
Vydra, Natalia, Toma, Agnieszka, Widlak, Wieslawa   +2 more
openaire   +2 more sources

ATF2 promotes urothelial cancer outgrowth via cooperation with androgen receptor signaling

Endocrine Connections, 2018
We investigated the functional role of ATF2, a transcription factor normally activated via its phosphorylation in response to phospho-ERK/MAPK signals, in the outgrowth of urothelial cancer.
Satoshi Inoue, Taichi Mizushima, Hiroki Ide, Guiyang Jiang, Takuro Goto, Yujiro Nagata, George J Netto, Hiroshi Miyamoto   +7 more
doaj   +1 more source

Adenovirus E1A requires c-Ras for full neoplastic transformation or suppression of differentiation of murine preadipocytes

, 2007
We recently demonstrated that the Adenovirus-5 E1A gene products (E1A), known E2F activators, can block the differentiation of murine preadipocytes and that differentiation suppression occurs at lower levels than required for full neoplastic ...
A. Vultur, Anagnostopoulou, A., J. Cao, R. Arulanandam, L. Raptis   +4 more
core   +1 more source

Mechanisms of radiation-induced neoplastic cell transformation [PDF]

, 1984
Studies with cultured mammalian cells demonstrated clearly that radiation can transform cells directly and can enhance the cell transformation by oncogenic DNA viruses.
C.A. Tobias, Yang, T. C. H., Tobias, C. A., T.C.H. Yang   +3 more
core   +1 more source

Histomorphological development and progression of gastric intramucosal papillary adenocarcinoma—a retrospective study

Frontiers in Oncology
ObjectiveThe aim of this study is to elucidate the developmental process, progression patterns, and histomorphological features of gastric-type intramucosal papillary adenocarcinoma.MethodsThis study employed a retrospective research method. Histological
Yang-Kun Wang, Xiong-Fei Zou, Wen-Yi Wang, Ying-Ying Li, Yan Zhong, Pei Guo, Tao Wang, Si-Liang Xu, Su-Nan Wang   +8 more
doaj   +1 more source

Suppression of Neoplastic Transformation by Low Doses of Low Let Radiation

Dose-Response, 2006
A major concern of exposure to low doses of radiation is the risk of cancer induction. Epidemiologic data are rarely powerful enough to accurately discriminate this risk at doses
J. Leslie Redpath PhD
doaj   +1 more source

Neoplastic potential of odontogenic cysts

Contemporary Clinical Dentistry, 2011
Odontogenic cysts and tumors are distinct entities and quite a common occurrence in the jaw bones. The lining of odontogenic cysts shows a potential for neoplastic transformation to non odontogenic malignancies like squamous cell carcinoma and ...
Zama Moosvi, S Amsavardani Tayaar, G S Kumar   +2 more
doaj   +1 more source

The Clinicopathological Features of Gastric Hyperplastic Polyps with Neoplastic Transformations: A Suggestion of Indication for Endoscopic Polypectomy

Gut and Liver, 2009
Background/AimsAlthough gastric hyperplastic polyps are usually considered as benign lesions, a low risk of carcinomatous conversion is currently recognized.
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Nuclear Factor kappa B is central to Marek’s Disease herpesvirus induced neoplastic transformation of CD30 expressing lymphocytes in-vivo [PDF]

, 2012
BACKGROUND:Marek's Disease (MD) is a hyperproliferative, lymphomatous, neoplastic disease of chickens caused by the oncogenic Gallid herpesvirus type 2 (GaHV-2MDV).
Joram J Buza, Buza, Joram, Kumar, Shyamesh, Cheng, Hans, Zhou, Huaijun, Buza, Joram J, Sugalesini Subramaniam, Shane C Burgess, Burgess, Shane C, Hsin-I Chiang, Kunec, Dusan, Burgess, Shane, Dusan Kunec, Hans H Cheng, Subramaniam, Sugalesini, Shyamesh Kumar, Chiang, Hsin-I, Pendarvis, Ken, Cheng, Hans H, Ken Pendarvis, Huaijun Zhou   +20 more
core   +1 more source