Radiation-Induced Neoplastic Transformation , Hormesis and Risk Assessment [PDF]
Dose-Response, 2007 Dose-response curves for various low-LET radiation sources have consistently been demonstrated to be J-shaped for the cancer-relevant endpoint of neoplastic transformation in vitro.
J. Leslie Redpath PhD, Eugene Elmore PhD
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Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation [PDF]
Neoplasia: An International Journal for Oncology Research, 2016 The current paradigm of pancreatic neoplastic transformation proposes an initial step whereby acinar cells convert into acinar-to-ductal metaplasias, followed by progression of these lesions into neoplasias under sustained oncogenic activity and ...
Yiannis Drosos +10 more
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MicroRNAs involved in neoplastic transformation of liver cancer stem cells [PDF]
Journal of Experimental & Clinical Cancer Research, 2010 Background The existence of cancer stem cells in hepatocellular carcinoma (HCC) has been verified by characterizing side population (SP) cells based on efflux of Hoechst 33342 dye from stem cells. Recent advances in microRNA (miRNA) biology have revealed
Wang Xinchuan +5 more
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L-type voltage-dependent Ca2+ channels expression involved in pre-neoplastic transformation of breast cancer [PDF]
Surgical and Experimental Pathology, 2022 Background Intracellular Ca2+ levels can modulate several cellular functions, including proliferation and other processes found altered in neoplastic cells.
Flávia Aguiar +4 more
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LRIG1 as a potential novel marker for neoplastic transformation in ocular surface squamous neoplasia. [PDF]
PLoS ONE, 2014 The leucine rich repeats and immunoglobulin-like protein 1 (LRIG1) is a newly discovered negative regulator of epidermal growth factor receptor (EGFR) and a proposed tumor suppressor.
Maho Nagata +5 more
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Adenomatoid Odontogenic Tumour Associated with Dentigerous Cyst: Case Report with Literature Review [PDF]
Journal of Clinical and Diagnostic Research, 2021 Adenomatoid Odontogenic Tumour (AOT) is a relatively uncommon benign odontogenic tumour composed of odontogenic epithelium in a variety of histoarchitectural patterns. Conventional AOT is predominantly seen in females in second decade of life exhibiting
Pradipta Ramgonda Patil +4 more
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Risk factors and clinical correlates of neoplastic transformation in gastric hyperplastic polyps in Chinese patients. [PDF]
Sci Rep, 2020 Gastric hyperplastic polyps (GHPs) have a potential risk of neoplastic transformation, but the responsible mechanisms have not yet been established. We conducted a study involving 55 patients (33 female) who had undergone endoscopic or surgical resection
Hu H +4 more
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Oncogenic FGFR Fusions Produce Centrosome and Cilia Defects by Ectopic Signaling
Cells, 2021 A single primary cilium projects from most vertebrate cells to guide cell fate decisions. A growing list of signaling molecules is found to function through cilia and control ciliogenesis, including the fibroblast growth factor receptors (FGFR). Aberrant
Alexandru Nita +3 more
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Frontiers in Pharmacology, 2022 The cytoplasmic actin isoforms (β- and γ-actins) contribute greatly to cellular processes such as cel-cell and cell-matrix interactions, as well as cell polarization, motility and division. Distinct isoforms modulations are linked to serious pathologies,
V. B. Dugina +3 more
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Functions of BLM Helicase in Cells: Is It Acting Like a Double-Edged Sword?
Frontiers in Genetics, 2021 DNA damage repair response is an important biological process involved in maintaining the fidelity of the genome in eukaryotes and prokaryotes. Several proteins that play a key role in this process have been identified.
Ekjot Kaur, Ritu Agrawal, Sagar Sengupta
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