Results 11 to 20 of about 383,457 (302)

Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models [PDF]

Computational and Structural Biotechnology Journal, 2022
Organoid modeling is a powerful, robust and efficient technology faithfully preserving physiological and pathological characteristics of tissues of origin.
Hua Zhao, Casey Collet, Dongzi Peng, Uttam K. Sinha, De-Chen Lin   +4 more
doaj   +2 more sources

Fine-tuned repression of Drp1-driven mitochondrial fission primes a ‘stem/progenitor-like state’ to support neoplastic transformation [PDF]

eLife, 2021
Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness.
Brian Spurlock, Danitra Parker, Malay Kumar Basu, Anita Hjelmeland, Sajina GC, Shanrun Liu, Gene P Siegal, Alan Gunter, Aida Moran, Kasturi Mitra   +9 more
doaj   +2 more sources

Gastric Hyperplastic Polyps: A Benign Entity? Analysis of Recurrence and Neoplastic Transformation in a Cohort Study [PDF]

GE: Portuguese Journal of Gastroenterology, 2021
Introduction: Hyperplastic polyps represent 30–93% of all gastric epithelial polyps. They are generally detected as innocuous incidental findings; however, they have a risk of neoplastic transformation and recurrence.
Mafalda João, Miguel Areia, Susana Alves, Luís Elvas, Filipe Taveira, Daniel Brito, Sandra Saraiva, Ana Teresa Cadime   +7 more
doaj   +2 more sources

Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation [PDF]

Nature Communications, 2023
The dysregulation of the m6A epitranscriptomic networks have been reported to contribute to the development of gliomas. Here, the authors utilize induced pluripotent stem cell-derived astrocytes with a p53 mutation and demonstrate that mutant p53 ...
An Xu, Mo Liu, Mo-Fan Huang, Yang Zhang, Ruifeng Hu, Julian A. Gingold, Ying Liu, Dandan Zhu, Chian-Shiu Chien, Wei-Chen Wang, Zian Liao, Fei Yuan, Chih-Wei Hsu, Jian Tu, Yao Yu, Taylor Rosen, Feng Xiong, Peilin Jia, Yi-Ping Yang, Danielle A. Bazer, Ya-Wen Chen, Wenbo Li, Chad D. Huff, Jay-Jiguang Zhu, Francesca Aguilo, Shih-Hwa Chiou, Nathan C. Boles, Chien-Chen Lai, Mien-Chie Hung, Zhongming Zhao, Eric L. Van Nostrand, Ruiying Zhao, Dung-Fang Lee   +32 more
doaj   +2 more sources

Cyclooxygenase-2 induces neoplastic transformation by inhibiting p53-dependent oncogene-induced senescence [PDF]

Scientific Reports, 2021
Much in vivo evidence indicates that cyclooxygenase-2 (COX-2) is deeply involved in tumorigenesis. Although it has been proposed that COX-2-derived pro-inflammatory prostanoids mediate the tumorigenic activity of COX-2, the tumorigenic mechanisms of COX ...
Hyeon Ju Lee, So Ra Kim, Yu-Jin Jung, Jeong A. Han   +3 more
doaj   +2 more sources

FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks [PDF]

Frontiers in Cell and Developmental Biology
PurposeFOS-like antigen 1 (FRA1), encoded by FOSL1, is an inducible subunit of the AP-1 transcription factor complex and regulates gene expression in response to proliferative and environmental cues.
Wuroud Al-Khayyat, Taylor Laframboise, Jessica Dougherty, Marc S. Mendonca, Douglas R. Boreham, Douglas R. Boreham, T. C. Tai, T. C. Tai, T. C. Tai, Christopher Thome, Christopher Thome, Christopher Thome, Sujeenthar Tharmalingam, Sujeenthar Tharmalingam, Sujeenthar Tharmalingam   +14 more
doaj   +2 more sources

Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation [PDF]

Nature Communications, 2021
The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D ...
Roser Vilarrasa-Blasi, Paula Soler-Vila, Núria Verdaguer-Dot, Núria Russiñol, Marco Di Stefano, Vicente Chapaprieta, Guillem Clot, Irene Farabella, Pol Cuscó, Marta Kulis, Xabier Agirre, Felipe Prosper, Renée Beekman, Silvia Beà, Dolors Colomer, Hendrik G. Stunnenberg, Ivo Gut, Elias Campo, Marc A. Marti-Renom, José Ignacio Martin-Subero   +19 more
doaj   +2 more sources

Oncogenic FGFR Fusions Produce Centrosome and Cilia Defects by Ectopic Signaling

Cells, 2021
A single primary cilium projects from most vertebrate cells to guide cell fate decisions. A growing list of signaling molecules is found to function through cilia and control ciliogenesis, including the fibroblast growth factor receptors (FGFR). Aberrant
Alexandru Nita, Sara P. Abraham, Pavel Krejci, Michaela Bosakova   +3 more
doaj   +1 more source

Adenomatoid Odontogenic Tumour Associated with Dentigerous Cyst: Case Report with Literature Review [PDF]

Journal of Clinical and Diagnostic Research, 2021
Adenomatoid Odontogenic Tumour (AOT) is a relatively uncommon benign odontogenic tumour composed of odontogenic epithelium in a variety of histoarchitectural patterns. Conventional AOT is predominantly seen in females in second decade of life exhibiting
Pradipta Ramgonda Patil, Hirkani Attarde, Priyanka Prakash Kamble, Sangeeta Patankar, Gokul Sridharan   +4 more
doaj   +1 more source

Disruption of 3D MCF-12A breast cell cultures by estrogens - An in vitro model for ER-mediated changes indicative of hormonal carcinogenesis [PDF]

, 2012
Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and 85 reproduction in any medium, provided the original author and source
Elisabete Silva, Irina Agoulnik, Stephanie Marchese   +2 more
core   +18 more sources