Results 291 to 300 of about 593,168 (347)

Cadmium-induced neoplastic transformation of human prostate epithelial cells

International Journal of Oncology, 2002
Cadmium is a ubiquitous environmental human carcinogen. Epidemiological and animal studies have suggested its carcinogenic potential on the prostate. In the present study, non-tumorigenic human prostate epithelial cells (pRNS-1-1) immortalized by simian papovavirus (SV40) were transformed after repeated exposures to cadmium.
Keiichiro, Nakamura, Yutaka, Yasunaga, Daejin, Ko, Linda L, Xu, Judd W, Moul, Donna M, Peehl, Shiv, Srivastava, Johng S, Rhim   +7 more
openaire   +2 more sources

Neoplastic transformation of hamster embryo cells by heavy ions

Advances in Space Research, 1998
We have studied the induction of morphological transformation of Syrian hamster embryo cells by low doses of heavy ions with different linear energy transfer (LET), ranging from 13 to 400 keV/micrometer. Exponentially growing cells were irradiated with 12C or 28Si ion beams generated by the Heavy Ion Medical Accelerator in Chiba (HIMAC), inoculated to ...
Z, Han, H, Suzuki, F, Suzuki, M, Suzuki, Y, Furusawa, T, Kato, M, Ikenaga   +6 more
openaire   +2 more sources

Some Characteristics of Neoplastic Cell Transformation in Transgenic Mice

1996
The role of the expression of different cellular genes and viral oncogenes in malignant cell transformation is discussed. We pay special attention to the role of the genes for growth factors and their receptors and homeobox genes in oncogenesis. Based on both the literature and our own data, specific features of tumors developed in transgenic mice are ...
I N, Shvemberger, A N, Ermilov
openaire   +2 more sources

Neoplastic Transformation of Rat Embryo Cells by Simian Papovavirus SV40

Nature, 1967
SV40 virus manifests its oncogenic action only in hamsters1 and in mastomys2. There are, however, reports of its transformation in vitro of cells of hamsters3, mice4, rabbits4, pigs4, cows5, monkeys6 and humans7. The purpose of our investigation was to determine whether the SV40 virus possesses the ability to transform rat cells in vitro.
A D, Altstein, N N, Vassiljeva, O F, Sarycheva   +2 more
openaire   +2 more sources

Cell Growth, Tissue Neogenesis, and Neoplastic Transformation

1984
Exponential growth is rarely observed in vivo. most mammalian tissues, whether normal or malignant, exhibit nonexponential kinetics in which growth decelerates continuously with time (1–10). This deceleration is characterized by a gradual but progressive increase in a tissue’s doubling time, and a corresponding decline in its specific growth rate.
openaire   +1 more source

In Which Cells Does Neoplastic Transformation Occur in Myelomatosis?

1992
Myelomatosis is strictly a neoplasm of plasma cells in bone marrow. It does not involve other sites of antibody production; thus, even when the monoclonal protein produced by the neoplastic clone is IgA1 or IgA2 the neoplastic cells are not found in the lamina propria of the gut (Leonard et al 1979).
openaire   +2 more sources

Neoplastic transformation of human epithelial cells in vitro.

Anticancer research, 1990
Efforts to investigate the progression of events that lead human cells of epithelial origin to become neoplastic in response to carcinogenic agents have been aided by the development of tissue culture systems for propagation of epithelial cells. We have recently developed an in vitro multistep model suitable for the study of human epithelial cell ...
openaire   +2 more sources

Neoplastic transformation of human cells in vitro.

Critical reviews in oncogenesis, 1993
Efforts to investigate the progression of events that lead normal human cells in culture to become neoplastic in response to carcinogenic agents have been aided by the development of the suitable in vitro model systems. For initial human cell transformation studies, a flat, nontumorigenic clonal line, originally derived from a human osteosarcoma (HOS),
openaire   +1 more source

Positive Mediators of Cell Proliferation in Neoplastic Transformation

2002
Cancer is not a single disease, but a collection of diseases all of which are related by a common root cause: the loss of controlled cell growth. Cancer begins as a clonal disease, that is, it stems from the genetic corruption of a single cell. This conversion of a normal cell into the neoplastic state is a multi-step phenomenon called neoplastic ...
James N. Welch, Susan A. Chrysogelos
openaire   +1 more source

Heterochromatin, Satellite DNA, and Transformed Neoplastic Cells

JNCI: Journal of the National Cancer Institute, 1972
N C, Popescu, J A, DiPaolo
openaire   +3 more sources