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Current Protocols in Toxicology, 1999
AbstractMorphological transformation of mammalian cells following exposure to a chemical agent is frequently used as a preliminary screen for the carcinogenic potential of the agent. This unit describes a protocol using Syrian hamster embryo (SHE) cells to assay transformation.
Jessica E. Sutherland, Max Costa
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AbstractMorphological transformation of mammalian cells following exposure to a chemical agent is frequently used as a preliminary screen for the carcinogenic potential of the agent. This unit describes a protocol using Syrian hamster embryo (SHE) cells to assay transformation.
Jessica E. Sutherland, Max Costa
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Spreading of non-transformed and transformed cells
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1984Mechanisms of cellular reactions responsible for the spreading of non-transformed cultured tissue cells on the surface of various substrata and relationships of these reactions to the control of cell proliferation are reviewed; the special role of the membrane-cytoskeleton interactions leading to extension and attachment of pseudopods is stressed ...
J M Vasiliev, J M Vasiliev
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Oncomodulin in Normal and Transformed Cells [PDF]
, 1990 The 3-dimensional crystal structure of oncomodulin from X-ray analysis reveals that it is quite similar to that of parvalbumin (F. Ahmed et al., in preparation). Oncomodulin has three domains composed of helix:metal-binding loop:helix arranged in a similar way to parvalbumin (Moews and Kretsinger 1975). This was not unexpected because it was known that
Macmanus, J., Brewer, L., Banville, D.
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The Cell Surface and Malignant Transformation
Annual Review of Medicine, 1974A malignant cell has lost many restrictions to which normal cells are subjected. For example, cell division is no longer tightly regulated by cell-cell contact or specific serum factors, serum-mediated hormonal feedback loops are broken, and cell recog nition of neighboring cells no longer leads to maintenance of cell position.
Pollack, R. E., Hough, P. V.
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Transglutaminase in cell proliferation and transformation
Medical Oncology and Tumor Pharmacotherapy, 1988Transglutaminase (TGase) activity was reduced in intact mitogen-stimulated human peripheral blood lymphocytes (PBL) when compared to intact resting PBL. Moreover, a treatment of the same quiescent immunocompetent cells with purified liver TGase and Ca2+ completely suppressed the mitogen-induced blast transformation.
Metafora S +8 more
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Studies on cell transformation
Somatic Cell Genetics, 1979Seven different transformation stigmata of the transformed CHO cell line, including morphological characteristics, growth behavior, cell membrane biochemical properties, and failure of fibronectin deposition, are reversed by addition of cAMP derivatives to the medium.
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Archiv f�r die gesamte Virusforschung, 1965
Studies were made on the effect of various doses of SV40 on the transformation rate of bovine cells, and the transformed cells were studied with regard to the presence of infectious SV40, the presence of the specific complement-fixing (CF) “tumor” antigen, and the transplantability into the autologous host.
Tore Wesslén, Hans Diderholm
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Studies were made on the effect of various doses of SV40 on the transformation rate of bovine cells, and the transformed cells were studied with regard to the presence of infectious SV40, the presence of the specific complement-fixing (CF) “tumor” antigen, and the transplantability into the autologous host.
Tore Wesslén, Hans Diderholm
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Cellular transformation and the ‘morphologic phenotype’ of transformed cells
Nature, 1978Expression of the product of the transforming gene (src) of RNA tumour viruses promotes growth and usually alters the adhesion, appearance and surface properties of cultured fibroblasts. The latter group of properties termed the 'morphologic phenotype' of transformed cells is largely due to diminished cell-to-substratum adhesion. The role of cyclic AMP,
Ira Pastan, Mark C. Willingham
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Mechanisms of T Cell Development and Transformation
Annual Review of Cell and Developmental Biology, 2011T cells are the key mediators in cell-mediated immunity. Their development and maturation involve a complex variety of interactions with nonlymphoid cell products and receptors. Highly specialized to defend against bacterial and viral infections, T cells also mediate immune surveillance against tumor cells and react to foreign tissues.
Koch Ute, Radtke Freddy
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Journal of Clinical Oncology, 2017
Purpose Histologic transformation of EGFR mutant lung adenocarcinoma (LADC) into small-cell lung cancer (SCLC) has been described as one of the major resistant mechanisms for epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs ...
J. Lee +22 more
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Purpose Histologic transformation of EGFR mutant lung adenocarcinoma (LADC) into small-cell lung cancer (SCLC) has been described as one of the major resistant mechanisms for epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs ...
J. Lee +22 more
semanticscholar +1 more source