Results 141 to 150 of about 1,019,407 (314)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Increased Osteoblastic and Osteocytic in Vitro Cell Viability by Yerba Mate (Ilex paraguariensis)

Background: Yerba mate (YM, Ilex paraguariensis) consumption beneficially affects the bones. However, whether YM components exert their effect on bone cells directly remains elusive.
Rico, María J., Buiatti Fagalde, Florencia, Rico, Maria Jose, Plotkin, Lilian I., Sanz, Natasha, Scharovsky, O. Graciela, D'Andrea, Florencia, Lombarte, Mercedes, Di Loreto, Verónica E., Di Loreto, Verónica Elina, D’Andrea, Florencia, Rozados, Viviana Rosa, Villarreal, Laureana, Rozados, Viviana R., Scharovsky, Olga Graciela, Brun, Lucas R., Brun, Lucas Ricardo Martín   +16 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Effects of quantum dot labeling on endothelial progenitor cell function and viability

, 2010
Endothelial progenitor cells (EPC) play an important role in repairing damaged endothelium. An effective imaging method for in vivo tracking of EPCs is essential for understanding EPC-based cell therapy.
Fu, Ying, Adams, M., Molnar, Matyas, Fu, Ying,, Yun Chen, Matyas Molnar, Molnár, Mátyás,, Adams, Michael, Mikeal Brisslert, Chen, Yun,, Ying Fu, Friberg, Peter, Peter Friberg, Moln\ue1r, M\ue1ty\ue1s, Brisslert, Mikael, Chen, Yun, Michael Adams   +16 more
core   +1 more source

Evaluation of Cytotoxicity and Genotoxicity of Micromeria pulegium (Rochel) Benth Extract in Human Lymphocytes and Gr-M Melanoma Cells in vitro

Genetics & Applications, 2018
Micromeria pulegium (Rochel) Benth. is an endemic species of Lamiacea family that includes frequently used plants in culinary and folk medicine. As cytotoxic potential of some species of Micromeria genus has been confirmed, this study aimed to test ...
Anja Haverić, Jasmina Čakar, Maida Hadžić, Sanin Haverić   +3 more
doaj  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

lncRNA BANCR suppresses cell viability and invasion and promotes apoptosis in non-small-cell lung cancer cells in vitro and in vivo

, 2019
Liu Yang,1 Guiting Liu21Sterile Supply Center, Mudanjiang Medical College, Hongqi Hospital, Mudanjiang City 157011, Heilongjiang Province, People’s Republic of China; 2Department of Thoracic Surgery, Mudanjiang Medical College, Hongqi Hospital ...
Yang L, Liu G
core  

Cell viability curves of peptoids.

, 2014
A, cell viability of MCF-7 cells treated with peptoid 1 for different time periods. Cell viability was measured with MTS assays; B, cell viability curve of 1achiral in MCF-7 and primary dermal fibroblast cells. 1achiral was more toxic to MCF-7 cells.
Stephen B. Willingham (528885), Annelise E. Barron (393021), Wei Huang (36889), Irving L. Weissman (254406), Mark L. Gonzalgo (528887), Ann M. Czyzewski (528886), Jiwon Seo (528884)   +6 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source