Results 1 to 10 of about 333,081 (160)
Illuminating developmental biology with cellular optogenetics [PDF]
Current Opinion in Biotechnology, 2018 In developmental biology, localization is everything. The same stimulus-cell signaling event or expression of a gene-can have dramatically different effects depending on the time, spatial position, and cell types in which it is applied. Yet the field has long lacked the ability to deliver localized perturbations with high specificity in vivo.
Heath E Johnson, Jared E Toettcher
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Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in Cancer. [PDF]
Cells, 2014 The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed cation-permeable ion channel with intrinsic kinase activity that plays important roles in various physiological functions. Biochemical and electrophysiological studies, in combination with molecular analyses of TRPM7, have generated insights into its ...
Yee NS, Kazi AA, Yee RK.
europepmc +5 more sources
Recent Advances in the Cellular and Developmental Biology of Phospholipases in Plants. [PDF]
Front Plant Sci, 2019 Phospholipases (PLs) are lipid-hydrolyzing enzymes known to have diverse signaling roles during plant abiotic and biotic stress responses. They catalyze lipid remodeling, which is required to generate rapid responses of plants to environmental cues. Moreover, they produce second messenger molecules, such as phosphatidic acid (PA) and thus trigger or ...
Takáč T, Novák D, Šamaj J.
europepmc +5 more sources
Protein interference applications in cellular and developmental biology using DARPins that recognize GFP and mCherry. [PDF]
Biol Open, 2014 ABSTRACT Protein–protein interactions are crucial for cellular homeostasis and play important roles in the dynamic execution of biological processes. While antibodies represent a well-established tool to study protein interactions of extracellular domains and secreted proteins, as well as in fixed and permeabilized cells, they usually ...
Brauchle M +8 more
europepmc +9 more sources
The cellular and developmental biology of medulloblastoma: Current perspectives on experimental therapeutics [PDF]
Cancer Biology and Therapy, 2010 Dysregulation of various signaling pathways that govern cerebellar development with respect to cell proliferation, growth arrest, apoptosis and differentiation has been postulated to contribute to medulloblastoma tumourigenesis. This review will highlight the unique nature of cerebellar development in terms of its derivation from two germinal matrices ...
Josephine NALBANTOĞLU
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Partial differential equations for self-organization in cellular and developmental biology [PDF]
Nonlinearity, 2008 Understanding the mechanisms governing and regulating the emergence of structure and heterogeneity within cellular systems, such as the developing embryo, represents a multiscale challenge typifying current integrative biology research, namely, explaining the macroscale behaviour of a system from microscale dynamics.
Ruth E Baker +2 more
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Rudolf Weber (1922–2015): a driving force in the transition of developmental biology into a molecular and cellular science [PDF]
Development Genes and Evolution, 2016 Prof. Dr. Rudolf Heinrich Weber passed away on December 23, 2015, at the high age of 93 years. Succeeding Fritz Baltzer and Fritz Erich Lehmann, he became the third in a line of outstanding developmental biologists at the University of Bern, Switzerland.
Daniel Schümperli
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Nature Communications, 2021 Learning-activated engram neurons play a critical role in memory recall but the role of these neurons in offline memory consolidation is unclear. The authors show that sleep-associated reactivation of learning-activated sensory neurons is necessary for ...
Brittany C. Clawson +13 more
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GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway
Nature Communications, 2022 Lysosomal biogenesis errors often result in diseases including mucolipidosis. Here Zhang and Yang et al. identify TMEM251/GCAF as a mannose-6-phosphate modification regulator that is necessary for correct lysosomal targeting, and classify Mucolipidosis ...
Weichao Zhang +14 more
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Whole body regeneration and developmental competition in two botryllid ascidians
EvoDevo, 2021 Background Botryllid ascidians are a group of marine invertebrate chordates that are colonial and grow by repeated rounds of asexual reproduction to form a colony of individual bodies, called zooids, linked by a common vascular network.
Shane Nourizadeh +4 more
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