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Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in Cancer. [PDF]

Cells, 2014
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed cation-permeable ion channel with intrinsic kinase activity that plays important roles in various physiological functions. Biochemical and electrophysiological studies, in combination with molecular analyses of TRPM7, have generated insights into its ...
Yee NS, Kazi AA, Yee RK.
europepmc   +5 more sources

Recent Advances in the Cellular and Developmental Biology of Phospholipases in Plants. [PDF]

Front Plant Sci, 2019
Phospholipases (PLs) are lipid-hydrolyzing enzymes known to have diverse signaling roles during plant abiotic and biotic stress responses. They catalyze lipid remodeling, which is required to generate rapid responses of plants to environmental cues. Moreover, they produce second messenger molecules, such as phosphatidic acid (PA) and thus trigger or ...
Takáč T, Novák D, Šamaj J.
europepmc   +5 more sources

Genome-wide discovery of structured noncoding RNAs in bacteria

BMC Microbiology, 2019
Background Structured noncoding RNAs (ncRNAs) play essential roles in many biological processes such as gene regulation, signaling, RNA processing, and protein synthesis. Among the most common groups of ncRNAs in bacteria are riboswitches.
Shira Stav, Ruben M. Atilho, Gayan Mirihana Arachchilage, Giahoa Nguyen, Gadareth Higgs, Ronald R. Breaker   +5 more
doaj   +1 more source

Precision multiplexed base editing in human cells using Cas12a-derived base editors

Nature Communications
Base editors enable the direct conversion of target nucleotides without introducing DNA double strand breaks, making them a powerful tool for creating point mutations in a human genome. However, current Cas9-derived base editing technologies have limited
Anabel Y. Schweitzer, Etowah W. Adams, Michael T. A. Nguyen, Monkol Lek, Farren J. Isaacs   +4 more
doaj   +1 more source

FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling

Nature Communications
Gastrulation, a critical developmental stage involving germ layer specification and axes formation, is a major point of failure in human development, contributing to pregnancy loss and congenital malformations.
Joseph Rufo, Chongxu Qiu, Dasol Han, Naomi Baxter, Gabrielle Daley, Jasmine Dhillon, Felix Wong, James J. Collins, Maxwell Z. Wilson   +8 more
doaj   +1 more source

The Parkinson’s disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration

Journal of Neuroinflammation
A growing body of evidence implicates inflammation as a key hallmark in the pathophysiology of Parkinson’s disease (PD), with microglia playing a central role in mediating neuroinflammatory signaling in the brain.
Henry Kurniawan, Sarah L. Nickels, Alise Zagare, Elisa Zuccoli, Isabel Rosety, Gemma Gomez-Giro, Enrico Glaab, Jens C. Schwamborn   +7 more
doaj   +1 more source

A Commander-independent function of COMMD3 in endosomal trafficking

eLife
Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradation in lysosomes.
Galen T Squiers, Chun Wan, James Gorder, Harrison Puscher, Jingshi Shen   +4 more
doaj   +1 more source

Synergistic exacerbation of oral mucositis caused by IL-23 deficiency and oral Candida albicans exposure

mBio
Targeted head and neck irradiation (HNI) used for cancer therapy causes mucosal damage and immune dysregulation, leaving cancer patients highly susceptible to infections of the oral mucosa.
John T. Dillon, Maura T. Hickey, Jessica Saul-McBeth, Trevor Glanz, Yusuf Daboul, Yashwanth R. Byreddy, Raymond Hohl, Jacqueline M. Kratch, Jia A. Thakker, Sarah L. Gaffen, Jacob Gibbs, Heather R. Conti   +11 more
doaj   +1 more source

TONSOKU prevents the formation of large tandem duplications and restrains ATR–WEE1 checkpoint activation

Nature Communications
Copy number variation (CNV) plays a fundamental role in modulating plant agronomic traits and tumorigenesis in animals. While frequently linked to replication stress, the mechanisms giving rise to CNVs are not fully elucidated.
Geoffrey Thomson, Axel Poulet, Yi-Chun Huang, Hong-Sheng Liao, Chantal LeBlanc, Yannick Jacob   +5 more
doaj   +1 more source

Genetic perspectives on the ascidian central nervous system

Invertebrate Survival Journal, 2009
In 2002, date of publication of the Ciona intestinalis genome, ascidians entered the post-genomic era. This tool had a fundamental role and has become the starting point for a series of new functional and genomic studies.
A Locascio, F Ristoratore, A Spagnuolo, L Zanetti, M Branno   +4 more
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