Results 91 to 100 of about 341,348 (303)

Three serendipitous pathways in E. coli can bypass a block in pyridoxal‐5′‐phosphate synthesis

Molecular Systems Biology, 2010
Bacterial genomes encode hundreds to thousands of enzymes, most of which are specialized for particular functions. However, most enzymes have inefficient promiscuous activities, as well, that generally serve no purpose.
Juhan Kim, Jamie P Kershner, Yehor Novikov, Richard K Shoemaker, Shelley D Copley   +4 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

The relaxin receptor as a therapeutic target – perspectives from evolution and drug targeting [PDF]

, 2018
The peptide relaxin was first identified as an important circulating hormone during pregnancy over 90 years ago. Research over many years defined the numerous biological roles that relaxin plays throughout pregnancy in many mammalian species.
Bathgate, Ross A.d., Martina Kocan, Sara V. Good, M. Akhter Hossain, Paul R. Gooley, Ross A.D. Bathgate, Sub Developmental Biology, Bogerd, Jan, Good, Sara V., Daniel J. Scott, Sergey Yegorov, Scott, Daniel J., Yegorov, Sergey, Kocan, Martina, Jan Bogerd, Gooley, Paul R., Developmental Biology, Hossain, M. Akhter   +17 more
core   +1 more source

Single-cell mapping of lipid metabolites using an infrared probe in human-derived model systems

Nature Communications
Understanding metabolic heterogeneity is the key to uncovering the underlying mechanisms of metabolic-related diseases. Current metabolic imaging studies suffer from limitations including low resolution and specificity, and the model systems utilized ...
Yeran Bai, Carolina M. Camargo, Stella M. K. Glasauer, Raymond Gifford, Xinran Tian, Andrew P. Longhini, Kenneth S. Kosik   +6 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Precision multiplexed base editing in human cells using Cas12a-derived base editors

Nature Communications
Base editors enable the direct conversion of target nucleotides without introducing DNA double strand breaks, making them a powerful tool for creating point mutations in a human genome. However, current Cas9-derived base editing technologies have limited
Anabel Y. Schweitzer, Etowah W. Adams, Michael T. A. Nguyen, Monkol Lek, Farren J. Isaacs   +4 more
doaj   +1 more source

Echinoderms : Focus on the Sea Urchin Model in Cellular and Developmental Biology

, 2021
Echinoderms, a sister group of chordates, is a group of exclusively marine animals. TheEchinodermata is an ancient phylum dating to at least 450 million years old and includingmore than 10,000 extant species present throughout the world’s oceans. The modernechinoderms belong to five classes: Echinoidea (e.g., sea urchins and sand dollars),Asteroidea (e.
Pontheaux, Florian, Roch, Fernando, Morales, Julia, Cormier, Patrick   +3 more
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

There is more than one way to turn a spherical cellular monolayer inside out: type B embryo inversion in Volvox globator

, 2011
Höhn S, Hallmann A. There is more than one way to turn a spherical cellular monolayer inside out: type B embryo inversion in Volvox globator. BMC Biology.
Höhn Stephanie, Hallmann Armin, Höhn, Stephanie, Hallmann, Armin ; https://orcid.org/, Armin Hallmann, Stephanie Höhn   +5 more
core   +2 more sources

Genome-wide discovery of structured noncoding RNAs in bacteria

BMC Microbiology, 2019
Background Structured noncoding RNAs (ncRNAs) play essential roles in many biological processes such as gene regulation, signaling, RNA processing, and protein synthesis. Among the most common groups of ncRNAs in bacteria are riboswitches.
Shira Stav, Ruben M. Atilho, Gayan Mirihana Arachchilage, Giahoa Nguyen, Gadareth Higgs, Ronald R. Breaker   +5 more
doaj   +1 more source