Results 101 to 110 of about 341,348 (303)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Cellular automata and dynamical systems [PDF]

In this thesis we investigate the theoretical nature of the mathematical structures termed cellular automata. Chapter 1: Reviews the origin and history of cellular automata in order to place the current work into context.
Clewlow, Les
core  

Developmental phase transitions in Norway spruce [PDF]

, 2013
Plant development proceeds through distinct phases that are controlled by complex networks of regulatory genetic circuits and fine-tuned by environmental and endogenous cues.
Uddenberg, Daniel
core  

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Decoys provide a scalable platform for the identification of plant E3 ubiquitin ligases that regulate circadian function

eLife, 2019
The circadian clock relies on regulated degradation of clock proteins to maintain rhythmicity. Despite this, we know few components that mediate protein degradation.
Ann Feke, Wei Liu, Jing Hong, Man-Wah Li, Chin-Mei Lee, Elton K Zhou, Joshua M Gendron   +6 more
doaj   +1 more source

Developmental, Cellular and Molecular Biology of Benign Prostatic Hyperplasia [PDF]

Differentiation, 2011
William A, Ricke, Jill A, Macoska, Gerald R, Cunha   +2 more
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The significance and scope of evolutionary developmental biology: A vision for the 21st century

, 2015
Evolutionary developmental biology (evo-devo) has undergone dramatic transformations since its emergence as a distinct discipline. This paper aims to highlight the scope, power, and future promise of evo-devo to transform and unify diverse aspects of ...
Cohen, C Sarah, Dworkin, Ian, Vallejo-Marín, Mario, Stollewerk, Angelika, De Tomaso, Anthony W, Roth, Siegfried, Sears, Karen E, Abouheif, Ehab, Brown, Federico D, Chiu, Chi-Hua, Matus, David Q, Diggle, Pamela, Ledon-Rettig, Cristina, Moczek, Armin P, Wittkopp, Patricia J   +14 more
core   +1 more source

FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling

Nature Communications
Gastrulation, a critical developmental stage involving germ layer specification and axes formation, is a major point of failure in human development, contributing to pregnancy loss and congenital malformations.
Joseph Rufo, Chongxu Qiu, Dasol Han, Naomi Baxter, Gabrielle Daley, Jasmine Dhillon, Felix Wong, James J. Collins, Maxwell Z. Wilson   +8 more
doaj   +1 more source