Results 131 to 140 of about 365,586 (305)
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Evolution of Self-Assembling Patterns in Cellular Automata using Development [PDF]
, 2011 This paper is concerned with the application of ideas inspired by developmental biology to the evolution of cellular automata rules using genetic programming. In particular, it is focused on so-called self-assembling patterns.
Johnson, Colin G., Öztürkeri, Can
core
, 2015 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)The aim of this study was to describe the accumulation of reserves during the somatic embryogenesis process in Passiflora edulis Sims FB-300, obtained from mature zygotic embryos, using ...
Cruz, Ana C. F. da +8 more
core +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Nature CommunicationsCopy number variation (CNV) plays a fundamental role in modulating plant agronomic traits and tumorigenesis in animals. While frequently linked to replication stress, the mechanisms giving rise to CNVs are not fully elucidated.
Geoffrey Thomson +5 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
, 2022 Azadirachtin, obtained from neem trees, can be a robust alternative to synthetic pesticides for the control of agricultural pests with no resistance problems. Azadirachtin-induced influences on mortality, life history traits and cellular immunity indicators of the lesser wax moth Achroia grisella (Fabricius, 1794) (Lepidoptera: Pyralidae) were ...
openaire +2 more sources
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
A perspective on molecular and cellular biology-based developmental toxicology biomarkers
BIOCELL, 2023 SUKHENDU DEY +3 more
openaire +1 more source