Results 261 to 270 of about 1,498,984 (353)

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

ALTERED MERISTEM PROGRAM1 sustains cellular differentiation by limiting HD-ZIP III transcription factor gene expression. [PDF]

Plant Physiol
Yang S, Poretska O, Poppenberger B, Sieberer T.   +3 more
europepmc   +1 more source

Cellular and molecular partners involved in gut morphogenesis and differentiation [PDF]

, 1998
M. Kédinger, Olivier Lefèbvre, Isabelle Duluc, Jean‐Noël Freund, Patricia Simon‐Assmann   +4 more
openalex   +1 more source

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

FEBS Open Bio, EarlyView.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper, Sridhar Sreeramulu, Benjamin T. Lanham, Elizabeth M. Engle, David Fushman, Harald Schwalbe   +5 more
wiley   +1 more source

Epigenetic Reprogramming and Inheritance of the Cellular Differentiation Status Following Transient Expression of a Nonfunctional Dominant-Negative Retinoblastoma Mutant in Murine Mesenchymal Stem Cells. [PDF]

Int J Mol Sci
Baryshev M, Maksimova I, Sasoveca I.
europepmc   +1 more source

Chromatin-Associated Membraneless Organelles in Regulation of Cellular Differentiation. [PDF]

Stem Cell Reports, 2020
Grosch M, Ittermann S, Shaposhnikov D, Drukker M.   +3 more
europepmc   +1 more source

Fibroblast growth factor receptor expression reflects cellular differentiation in human oral squamous carcinoma cell lines [PDF]

, 1998
C S Drugan
openalex   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

The contributions of DNA accessibility and transcription factor occupancy to enhancer activity during cellular differentiation. [PDF]

G3 (Bethesda)
Long T, Bhattacharyya T, Repele A, Naylor M, Nooti S, Krueger S, Manu.   +6 more
europepmc   +1 more source

Surface sensing stimulates cellular differentiation in Caulobacter crescentus. [PDF]

Proc Natl Acad Sci U S A, 2020
Snyder RA, Ellison CK, Severin GB, Whitfield GB, Waters CM, Brun YV.   +5 more
europepmc   +1 more source